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Abstract

Plasma and tissue disposition of paclitaxel (taxol) after intraperitoneal administration in mice.

F Innocenti, R Danesi, A Di Paolo, C Agen, D Nardini, G Bocci and M Del Tacca
Drug Metabolism and Disposition July 1995, 23 (7) 713-717;
F Innocenti
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R Danesi
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A Di Paolo
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C Agen
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D Nardini
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G Bocci
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M Del Tacca
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Abstract

The pharmacokinetics of single intraperitoneal doses of paclitaxel (18 and 36 mg/kg) in mice were investigated in the present study. The analysis of drug concentrations by HPLC indicated that the plasma Cmax (13.0 +/- 3.1 and 25.7 +/- 2.8 micrograms/ml, respectively) were reached at the 2nd hr. The values of CL were low (0.06 and 0.1 ml/min, respectively), and t1/2 beta values of 3.0 and 3.7 hr were found, after 18 and 36 mg/kg, respectively. The highest tissue concentrations were observed in the liver (50.2 +/- 3.1 and 92.0 +/- 9.5 micrograms/g respectively), followed by the pancreas (39.3 +/- 9.9 micrograms/g) and the ovary (53.4 +/- 5.6 micrograms/g) after 18 and 36 mg/kg, respectively. In the case of the colic tissue, paclitaxel Cmax were 14.4 +/- 0.8 and 32.8 +/- 3.5 micrograms/g at the 3rd hr, respectively, with sustained drug levels still detectable 24 hr after treatment. Paclitaxel Cmax values of 12.7 +/- 3.0 and 53.4 +/- 5.6 micrograms/g were detected in the ovary after 18 and 36 mg/kg, respectively. The overall results provide evidence that, after intraperitoneal administration, paclitaxel concentrates in peritoneal organs; however, the intraperitoneal route does not prevent systemic drug exposure, allowing high and sustained levels of paclitaxel also in several extraperitoneal tissues.

 

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Drug Metabolism and Disposition
Vol. 23, Issue 7
1 Jul 1995
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Abstract

Plasma and tissue disposition of paclitaxel (taxol) after intraperitoneal administration in mice.

F Innocenti, R Danesi, A Di Paolo, C Agen, D Nardini, G Bocci and M Del Tacca
Drug Metabolism and Disposition July 1, 1995, 23 (7) 713-717;

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Abstract

Plasma and tissue disposition of paclitaxel (taxol) after intraperitoneal administration in mice.

F Innocenti, R Danesi, A Di Paolo, C Agen, D Nardini, G Bocci and M Del Tacca
Drug Metabolism and Disposition July 1, 1995, 23 (7) 713-717;
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