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Table of Contents

January 01, 1996; Volume 24,Issue 1

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Three-dimensional quantitative structure-activity relationship for inhibitors of cytochrome P4502C9.
J P Jones, M He, W F Trager and A E Rettie

Drug Metabolism and Disposition January 1996, 24 (1) 1-6;
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Trout liver slices for metabolism and toxicity studies.
Y Singh, J B Cooke, D E Hinton and M G Miller

Drug Metabolism and Disposition January 1996, 24 (1) 7-14;
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Cytochrome P4502E1- and cytochrome P4502B1/2B2-catalyzed carbon tetrachloride metabolism: effects on signal transduction as demonstrated by altered immediate-early (c-Fos and c-Jun) gene expression and nuclear AP-1 and NF-kappa B transcription factor levels.
A Gruebele, K Zawaski, D Kaplan and R F Novak

Drug Metabolism and Disposition January 1996, 24 (1) 15-22;
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Erythromycin as a specific substrate for cytochrome P4503A isozymes and identification of a high-affinity erythromycin N-demethylase in adult female rats.
X J Zhang and P E Thomas

Drug Metabolism and Disposition January 1996, 24 (1) 23-27;
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Gender differences in toxicokinetics, liver metabolism, and plasma esterase activity: observations from a chronic (27-week) toxicity study of enalapril/diltiazem combinations in rats.
L E Los, D A Welsh, E G Herold, W J Bagdon and A G Zacchei

Drug Metabolism and Disposition January 1996, 24 (1) 28-33;
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The pharmacokinetics and extra-hepatic clearance of remifentanil, a short acting opioid agonist, in male beagle dogs during constant rate infusions.
J P Chism and D E Rickert

Drug Metabolism and Disposition January 1996, 24 (1) 34-40;
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N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine and 2,2,2-trichloroethanol: two novel metabolites of tetrachloroethene in humans after occupational exposure.
G Birner, A Rutkowska and W Dekant

Drug Metabolism and Disposition January 1996, 24 (1) 41-48;
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Pharmacokinetics of stable isotopically labeled L-histidine in humans and the assessment of in vivo histidine ammonia lyase activities.
T Furuta, K Okamiya, H Shibasaki and Y Kasuya

Drug Metabolism and Disposition January 1996, 24 (1) 49-54;
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Synthesis of putative metabolites and investigation of the metabolic fate of gliclazide, [1-(3-azabicyclo(3,3,0)oct-3-yl)-3-(4-methylphenylsulfonyl) urea], in diabetic patients.
A R Taylor, R D Brownsill, H Grandon, F Lefoulon, A Petit, W Luijten, P G Kopelman and B Walther

Drug Metabolism and Disposition January 1996, 24 (1) 55-64;
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Metabolism of the bisphosphonate ester U-91502 in rats.
J G Slatter, K L Feenstra, M J Hauer, D A Kloosterman, A H Parton, P E Sanders, G Scott and W Speed

Drug Metabolism and Disposition January 1996, 24 (1) 65-73;
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Participation of cytochromes P4502B and P4503A in cocaine toxicity in rat hepatocytes.
T S Poet, C A McQueen and J R Halpert

Drug Metabolism and Disposition January 1996, 24 (1) 74-80;
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Mouse liver microsomal metabolism of chloral hydrate, trichloroacetic acid, and trichloroethanol leading to induction of lipid peroxidation via a free radical mechanism.
Y C Ni, T Y Wong, R V Lloyd, T M Heinze, S Shelton, D Casciano, F F Kadlubar and P P Fu

Drug Metabolism and Disposition January 1996, 24 (1) 81-90;
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Pharmacokinetics, absolute bioavailability, and disposition of [14C]nefazodone in humans.
R H Barbhaiya, K A Dandekar and D S Greene

Drug Metabolism and Disposition January 1996, 24 (1) 91-95;
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Disposition kinetics of human epidermal growth factor (hEGF1-53) and its truncated fragment (hEGF1-48) in rats.
B S Kuo, G D Nordblom, R C Dudeck, L S Kirkish and D S Wright

Drug Metabolism and Disposition January 1996, 24 (1) 96-104;
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The 3-hydroxypyridin-4-ones more effectively chelate aluminum in a rabbit model of aluminum intoxication than does desferrioxamine.
R A Yokel, K A Meurer, T L Skinner and A M Fredenburg

Drug Metabolism and Disposition January 1996, 24 (1) 105-111;
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Propranolol hydroxylation and N-desisopropylation by cytochrome P4502D6: studies using the yeast-expressed enzyme and NADPH/O2 and cumene hydroperoxide-supported reactions.
N Bichara, M S Ching, C L Blake, H Ghabrial and R A Smallwood

Drug Metabolism and Disposition January 1996, 24 (1) 112-118;
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Identification of beta-glucuronidase-resistant diastereomeric glucuronides of 3-hydroxy-3-methyloxindole formed during 3-methylindole metabolism in goats.
D J Smith, M L Appleton, J R Carlson and G S Yost

Drug Metabolism and Disposition January 1996, 24 (1) 119-125;
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[O-methyl 14C]naproxen O-demethylase activity in human liver microsomes: evidence for the involvement of cytochrome P4501A2 and P4502C9/10.
A D Rodrigues, M J Kukulka, E M Roberts, D Ouellet and T R Rodgers

Drug Metabolism and Disposition January 1996, 24 (1) 126-136;