Drug Metabolism and Disposition: 24 (10)

October 01, 1996; Volume 24,Issue 10

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The importance of nonspecific binding in in vitro matrices, its impact on enzyme kinetic studies of drug metabolism reactions, and implications for in vitro-in vivo correlations.
R S Obach

Drug Metabolism and Disposition October 1996, 24 (10) 1047-1049;
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Stereoselective irreversible binding of ketoprofen glucuronides to albumin. Characterization of the site and the mechanism.
N Presle, F Lapicque, S Fournel-Gigleux, J Magdalou and P Netter

Drug Metabolism and Disposition October 1996, 24 (10) 1050-1057;
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Systemic clearance and demethylation of caffeine in sheep and cattle.
T J Danielson and L R Golsteyn

Drug Metabolism and Disposition October 1996, 24 (10) 1058-1061;
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Comparative toxicokinetics of methanol in pregnant and nonpregnant rodents.
K W Ward and G M Pollack

Drug Metabolism and Disposition October 1996, 24 (10) 1062-1070;
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Excretion and metabolism of tipredane, a novel glucocorticoid, in the rat, mouse, monkey, and human.
A E Cooper, A J Gray, J Collington, H Seddon, I Beattie and C J Logan

Drug Metabolism and Disposition October 1996, 24 (10) 1071-1080;
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Human CYP2C19 is a major omeprazole 5-hydroxylase, as demonstrated with recombinant cytochrome P450 enzymes.
W G Karam, J A Goldstein, J M Lasker and B I Ghanayem

Drug Metabolism and Disposition October 1996, 24 (10) 1081-1087;
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Reversal of stereoselectivity in the hepatic availability of verapamil in isolated perfused rat livers. Role of protein binding.
R Mehvar and J Reynolds

Drug Metabolism and Disposition October 1996, 24 (10) 1088-1094;
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Regulation of rat hepatic sulfotransferase gene expression by glucocorticoid hormones.
M Runge-Morris, K Rose and T A Kocarek

Drug Metabolism and Disposition October 1996, 24 (10) 1095-1101;
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Disposition of a novel recombinant antithrombotic agent, RG 12986, in cynomolgus monkeys.
D S Wells, R Hensel, C Loullis, P Brophy, M E Mullin, E Murray and G Ricca

Drug Metabolism and Disposition October 1996, 24 (10) 1102-1106;
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Transfer of different nonsteroidal antiinflammatory drugs via the lymphatic system in the rat.
R Oelkers, M Ionac, K Erb, K Brune and G Geisslinger

Drug Metabolism and Disposition October 1996, 24 (10) 1107-1110;
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Species differences in the pharmacokinetics and metabolism of indinavir, a potent human immunodeficiency virus protease inhibitor.
J H Lin, M Chiba, S K Balani, I W Chen, G Y Kwei, K J Vastag and J A Nishime

Drug Metabolism and Disposition October 1996, 24 (10) 1111-1120;
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The nifedipine-rifampin interaction. Evidence for induction of gut wall metabolism.
N Holtbecker, M F Fromm, H K Kroemer, E E Ohnhaus and H Heidemann

Drug Metabolism and Disposition October 1996, 24 (10) 1121-1123;
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Isolation and identification of metabolites of leukotriene A4 hydrolase inhibitor SC-57461 in rats.
J H Yuan, J Birkmeier, D C Yang, J D Hribar, N Liu, R Bible, E Hajdu, M Rock and G Schoenhard

Drug Metabolism and Disposition October 1996, 24 (10) 1124-1133;
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Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human.
R A McLellan, R K Drobitch, M Monshouwer and K W Renton

Drug Metabolism and Disposition October 1996, 24 (10) 1134-1138;
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Metabolism of an atypical antipsychotic agent, 3-[4-[4-(6-fluorobenzo[b]thien-3-yl)-1-piperazinyl]butyl]-2, 5,5-trimethyl-4-thiazolidinone (HP236).
A E Mutlib, J Jurcak and N Hrib

Drug Metabolism and Disposition October 1996, 24 (10) 1139-1150;
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Characterization of glucuronidated phase II metabolites of the immunosuppressant cyclosporine in urine of transplant patients using time-of-flight secondary-ion mass spectrometry.
K Meyer, M Fobker, U Christians, M Erren, K F Sewing, G Assmann and A Benninghoven

Drug Metabolism and Disposition October 1996, 24 (10) 1151-1154;
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Role of altered metabolism in dideoxynucleoside pharmacokinetics. Studies of 2'-beta-fluoro-2',3'-dideoxyinosine and 2'-beta-fluoro-2',3'-dideoxyadenosine in rats.
D Singhal, M E Morgan and B D Anderson

Drug Metabolism and Disposition October 1996, 24 (10) 1155-1161;
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Stereoselective disposition of the enantiomers of the benzoquinolinone LY191704, a human type I 5 alpha-reductase inhibitor. Differences between rats and dogs.
N A Farid, K M Schreiner, N L Coleman, R B Van Lier and S A Wrighton

Drug Metabolism and Disposition October 1996, 24 (10) 1162-1165;

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