Drug Metabolism and Disposition: 24 (11)

November 01, 1996; Volume 24,Issue 11

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Identification of 2,6-xylidine as a major lidocaine metabolite in human liver slices.
R J Parker, J M Collins and J M Strong

Drug Metabolism and Disposition November 1996, 24 (11) 1167-1173;
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Metabolism of lisofylline and pentoxifylline in human liver microsomes and cytosol.
J A Lillibridge, T F Kalhorn and J T Slattery

Drug Metabolism and Disposition November 1996, 24 (11) 1174-1179;
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Improved bacterial expression of the human P form phenolsulfotransferase. Applications to drug metabolism.
A J Lewis, M M Kelly, U K Walle, E A Eaton, C N Falany and T Walle

Drug Metabolism and Disposition November 1996, 24 (11) 1180-1185;
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Purification and characterization of rhesus monkey liver amido hydrolases and their roles in the metabolic polymorphism for E6123, a platelet-activating factor receptor antagonist.
K Kusano, T Seko, S Tanaka, Y Shikata, T Ando, S Ida, M Hosokawa, T Satoh, T Yuzuriha and T Horie

Drug Metabolism and Disposition November 1996, 24 (11) 1186-1191;
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Acetaminophen-induced hepatotoxicity. Analysis of total covalent binding vs. specific binding to cysteine.
A M Matthews, D W Roberts, J A Hinson and N R Pumford

Drug Metabolism and Disposition November 1996, 24 (11) 1192-1196;
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Regulation of cytochrome P450 expression by inhibitors of hydroxymethylglutaryl-coenzyme A reductase in primary cultured rat hepatocytes and in rat liver.
T A Kocarek and A B Reddy

Drug Metabolism and Disposition November 1996, 24 (11) 1197-1204;
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Pharmacokinetics and metabolism in rats of 2,4-diamino-6-benzyloxy-5- nitrosopyrimidine, an inactivator of O6-alkylguanine-DNA alkyltransferase.
S K Roy, R C Moschel and M E Dolan

Drug Metabolism and Disposition November 1996, 24 (11) 1205-1211;
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Role of human cytochrome P4502A6 in C-oxidation of nicotine.
M Nakajima, T Yamamoto, K Nunoya, T Yokoi, K Nagashima, K Inoue, Y Funae, N Shimada, T Kamataki and Y Kuroiwa

Drug Metabolism and Disposition November 1996, 24 (11) 1212-1217;
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Cryopreservation of rat and mouse hepatocytes. I. Comparative viability studies.
N J Swales, C Luong and J Caldwell

Drug Metabolism and Disposition November 1996, 24 (11) 1218-1223;
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Cryopreservation of rat and mouse hepatocytes. II. Assessment of metabolic capacity using testosterone metabolism.
N J Swales, T Johnson and J Caldwell

Drug Metabolism and Disposition November 1996, 24 (11) 1224-1230;
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Metabolism and excretion of trovafloxacin, a new quinolone antibiotic, in Sprague-Dawley rats and beagle dogs. Effect of bile duct cannulation on excretion pathways.
D K Dalvie, N B Khosla, K A Navetta and K E Brighty

Drug Metabolism and Disposition November 1996, 24 (11) 1231-1240;
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Pharmacokinetics and steady-state tissue distribution of L- and D-isomers of nitroarginine in rats.
M A Tabrizi-Fard and H L Fung

Drug Metabolism and Disposition November 1996, 24 (11) 1241-1246;
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Formation of a metabolic intermediate complex of cytochrome P4502B1 by clorgyline.
U Sharma, E S Roberts and P F Hollenberg

Drug Metabolism and Disposition November 1996, 24 (11) 1247-1253;
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Role of cytochrome P450 in oxazaphosphorine metabolism. Deactivation via N-dechloroethylation and activation via 4-hydroxylation catalyzed by distinct subsets of rat liver cytochromes P450.
L Yu and D J Waxman

Drug Metabolism and Disposition November 1996, 24 (11) 1254-1262;
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Species and organ differences in first-pass metabolism of the ester prodrug L-751,164 in dogs and monkeys. In vivo and in vitro studies.
T Prueksaritanont, L M Gorham, J D Ellis, C Fernandez-Metzler, P Deluna, J R Gehret, K L Strong, J H Hochman, B C Askew, M E Duggan, J D Gilbert, J H Lin and K P Vyas

Drug Metabolism and Disposition November 1996, 24 (11) 1263-1271;
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Structural identification of three metabolites and a degradation product of the macrolide immunosuppressant sirolimus (rapamycin) by electrospray-MS/MS after incubation with human liver microsomes.
F Streit, U Christians, H M Schiebel, A Meyer and K F Sewing

Drug Metabolism and Disposition November 1996, 24 (11) 1272-1278;
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Excretion of oral 9-cis-retinoic acid in the rat.
B Disdier, H Bun, M Placidi and A Durand

Drug Metabolism and Disposition November 1996, 24 (11) 1279-1281;
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Dithionite-supported hydroxylation of palmitic acid by cytochrome P450BM-3.
X Fang and J R Halpert

Drug Metabolism and Disposition November 1996, 24 (11) 1282-1285;

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