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Drug Metabolism & Disposition

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Table of Contents

April 01, 1996; Volume 24,Issue 4
  • You have access
    A gas-liquid system for enzyme kinetic studies of volatile organic chemicals. Determination of enzyme kinetic constants and partition coefficients of trichloroethylene.
    I Y Hwang, K F Reardon, J D Tessari and R S Yang
    Drug Metabolism and Disposition April 1996, 24 (4) 377-382;
  • You have access
    [14C]7-ethoxycoumarin metabolism by precision-cut rat hepatic slices.
    S E Ball, V E Thiel, C O Tio, H K Lim, J Kao, S F Sisenwine and J Scatina
    Drug Metabolism and Disposition April 1996, 24 (4) 383-389;
  • You have access
    Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats.
    B I Ghanayem and L T Burka
    Drug Metabolism and Disposition April 1996, 24 (4) 390-394;
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    Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2.
    H Raza, R S King, R B Squires, F P Guengerich, D W Miller, J P Freeman, N P Lang and F F Kadlubar
    Drug Metabolism and Disposition April 1996, 24 (4) 395-400;
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    Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450.
    M B Sewer, D R Koop and E T Morgan
    Drug Metabolism and Disposition April 1996, 24 (4) 401-407;
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    A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine.
    D A Delker, T K Bammler and D W Rosenberg
    Drug Metabolism and Disposition April 1996, 24 (4) 408-413;
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    Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies.
    K L Kunze, L C Wienkers, K E Thummel and W F Trager
    Drug Metabolism and Disposition April 1996, 24 (4) 414-421;
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    Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies.
    D J Black, K L Kunze, L C Wienkers, B E Gidal, T L Seaton, N D McDonnell, J S Evans, J E Bauwens and W F Trager
    Drug Metabolism and Disposition April 1996, 24 (4) 422-428;
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    Warfarin-fluconazole. III. A rational approach to management of a metabolically based drug interaction.
    K L Kunze and W F Trager
    Drug Metabolism and Disposition April 1996, 24 (4) 429-435;
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    Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
    W Tang, A G Borel and F S Abbott
    Drug Metabolism and Disposition April 1996, 24 (4) 436-446;
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    Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.
    D K Walker, C T Alabaster, G S Congrave, M B Hargreaves, R Hyland, B C Jones, L J Reed and D A Smith
    Drug Metabolism and Disposition April 1996, 24 (4) 447-455;
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    Concentration-dependent tubular secretion of acetazolamide and its inhibition by salicylic acid in the isolated perfused rat kidney.
    D R Taft, D J Chapron, D J Fournier and K R Sweeney
    Drug Metabolism and Disposition April 1996, 24 (4) 456-461;
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    In vitro hydroxylation and epoxidation of some isomeric lauric acid analogs by rat liver microsomes. Identification of metabolites and effects of clofibrate or phenobarbital pretreatment.
    J L Boucher, M Delaforge, J P Salaün, F Pinot, F Durst, P Pflieger and C Mioskowski
    Drug Metabolism and Disposition April 1996, 24 (4) 462-468;
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    Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s).
    S Madden, J L Maggs and B K Park
    Drug Metabolism and Disposition April 1996, 24 (4) 469-479;
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    Diversion or prevention of biliary outflow from the liver diminishes the renal uptake of injected inorganic mercury.
    R K Zalups and D W Barfuss
    Drug Metabolism and Disposition April 1996, 24 (4) 480-486;
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    Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.
    J E Sharer and S A Wrighton
    Drug Metabolism and Disposition April 1996, 24 (4) 487-494;
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    Incorporation of codeine and metabolites into hair. Role of pigmentation.
    S P Gygi, R E Joseph, E J Cone, D G Wilkins and D E Rollins
    Drug Metabolism and Disposition April 1996, 24 (4) 495-501;
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    Effect of total parenteral nutrition containing lipid calories on hepatic drug metabolism in rats.
    R B Raftogianis, M R Franklin and R E Galinsky
    Drug Metabolism and Disposition April 1996, 24 (4) 502-505;
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In this issue

Drug Metabolism and Disposition
Vol. 24, Issue 4
1 Apr 1996
  • Table of Contents
  • Table of Contents (PDF)
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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