Drug Metabolism and Disposition: 24 (4)

April 01, 1996; Volume 24,Issue 4

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A gas-liquid system for enzyme kinetic studies of volatile organic chemicals. Determination of enzyme kinetic constants and partition coefficients of trichloroethylene.
I Y Hwang, K F Reardon, J D Tessari and R S Yang

Drug Metabolism and Disposition April 1996, 24 (4) 377-382;
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[14C]7-ethoxycoumarin metabolism by precision-cut rat hepatic slices.
S E Ball, V E Thiel, C O Tio, H K Lim, J Kao, S F Sisenwine and J Scatina

Drug Metabolism and Disposition April 1996, 24 (4) 383-389;
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Excretion and identification of methacrylonitrile metabolites in the bile of male F344 rats.
B I Ghanayem and L T Burka

Drug Metabolism and Disposition April 1996, 24 (4) 390-394;
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Metabolism of 2-amino-alpha-carboline. A food-borne heterocyclic amine mutagen and carcinogen by human and rodent liver microsomes and by human cytochrome P4501A2.
H Raza, R S King, R B Squires, F P Guengerich, D W Miller, J P Freeman, N P Lang and F F Kadlubar

Drug Metabolism and Disposition April 1996, 24 (4) 395-400;
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Endotoxemia in rats is associated with induction of the P4504A subfamily and suppression of several other forms of cytochrome P450.
M B Sewer, D R Koop and E T Morgan

Drug Metabolism and Disposition April 1996, 24 (4) 401-407;
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A comparative study of hepatic and colonic metabolic enzymes in inbred mouse lines before and after treatment with the colon carcinogen, 1,2-dimethylhydrazine.
D A Delker, T K Bammler and D W Rosenberg

Drug Metabolism and Disposition April 1996, 24 (4) 408-413;
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Warfarin-fluconazole. I. Inhibition of the human cytochrome P450-dependent metabolism of warfarin by fluconazole: in vitro studies.
K L Kunze, L C Wienkers, K E Thummel and W F Trager

Drug Metabolism and Disposition April 1996, 24 (4) 414-421;
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Warfarin-fluconazole. II. A metabolically based drug interaction: in vivo studies.
D J Black, K L Kunze, L C Wienkers, B E Gidal, T L Seaton, N D McDonnell, J S Evans, J E Bauwens and W F Trager

Drug Metabolism and Disposition April 1996, 24 (4) 422-428;
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Warfarin-fluconazole. III. A rational approach to management of a metabolically based drug interaction.
K L Kunze and W F Trager

Drug Metabolism and Disposition April 1996, 24 (4) 429-435;
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Conjugation of glutathione with a toxic metabolite of valproic acid, (E)-2-propyl-2,4-pentadienoic acid, catalyzed by rat hepatic glutathione-S-transferases.
W Tang, A G Borel and F S Abbott

Drug Metabolism and Disposition April 1996, 24 (4) 436-446;
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Significance of metabolism in the disposition and action of the antidysrhythmic drug, dofetilide. In vitro studies and correlation with in vivo data.
D K Walker, C T Alabaster, G S Congrave, M B Hargreaves, R Hyland, B C Jones, L J Reed and D A Smith

Drug Metabolism and Disposition April 1996, 24 (4) 447-455;
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Concentration-dependent tubular secretion of acetazolamide and its inhibition by salicylic acid in the isolated perfused rat kidney.
D R Taft, D J Chapron, D J Fournier and K R Sweeney

Drug Metabolism and Disposition April 1996, 24 (4) 456-461;
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In vitro hydroxylation and epoxidation of some isomeric lauric acid analogs by rat liver microsomes. Identification of metabolites and effects of clofibrate or phenobarbital pretreatment.
J L Boucher, M Delaforge, J P Salaün, F Pinot, F Durst, P Pflieger and C Mioskowski

Drug Metabolism and Disposition April 1996, 24 (4) 462-468;
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Bioactivation of carbamazepine in the rat in vivo. Evidence for the formation of reactive arene oxide(s).
S Madden, J L Maggs and B K Park

Drug Metabolism and Disposition April 1996, 24 (4) 469-479;
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Diversion or prevention of biliary outflow from the liver diminishes the renal uptake of injected inorganic mercury.
R K Zalups and D W Barfuss

Drug Metabolism and Disposition April 1996, 24 (4) 480-486;
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Identification of the human hepatic cytochromes P450 involved in the in vitro oxidation of antipyrine.
J E Sharer and S A Wrighton

Drug Metabolism and Disposition April 1996, 24 (4) 487-494;
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Incorporation of codeine and metabolites into hair. Role of pigmentation.
S P Gygi, R E Joseph, E J Cone, D G Wilkins and D E Rollins

Drug Metabolism and Disposition April 1996, 24 (4) 495-501;
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Effect of total parenteral nutrition containing lipid calories on hepatic drug metabolism in rats.
R B Raftogianis, M R Franklin and R E Galinsky

Drug Metabolism and Disposition April 1996, 24 (4) 502-505;

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