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Drug Metabolism & Disposition

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Table of Contents

October 01, 1997; Volume 25,Issue 10

Articles

  • You have access
    Pharmacokinetics and Disposition of the Oxytocin Receptor Antagonist L-368,899 in Rats and Dogs
    Kathryn L. Thompson, Styliani H. Vincent, Randall R. Miller, Adria E. Colletti, Raul F. Alvaro, Michael A. Wallace, William P. Feeney and Shuet-Hing Lee Chiu
    Drug Metabolism and Disposition October 1997, 25 (10) 1113-1118;
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    Cytochrome P4503A4-Mediated N-Demethylation of the Antiprogestins Lilopristone and Onapristone
    Graham R. Jang and Leslie Z. Benet
    Drug Metabolism and Disposition October 1997, 25 (10) 1119-1122;
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    Biliary Excretion of Pravastatin in Rats: Contribution of the excretion pathway mediated by canalicular multispecific organic anion transporter (cMOAT)
    Masayo Yamazaki, Sayoko Akiyama, Kayoko Ni’inuma, Ryuichiro Nishigaki and Yuichi Sugiyama
    Drug Metabolism and Disposition October 1997, 25 (10) 1123-1129;
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    In Vitro Comparison of Cytochrome P450-Mediated Metabolic Activities in Human, Dog, Cat, and Horse
    Nathalie Chauret, Annick Gauthier, Jean Martin and Deborah A. Nicoll-Griffith
    Drug Metabolism and Disposition October 1997, 25 (10) 1130-1136;
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    Inhibition of Glutathione Conjugation by Glutathione Analogues in the Perfused Rat Liver
    Sivi Ouwerkerk-Mahadevan, Rommel G. Tirona, Richard A. Ripping, Jan H. T. M. Ploemen, Peter J. van Bladeren, K. Sandy Pang, Jacques H. van Boom and Gerard J. Mulder
    Drug Metabolism and Disposition October 1997, 25 (10) 1137-1143;
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    Oxidative Metabolism of a Rexinoid and Rapid Phase II Metabolite Identification by Mass Spectrometry
    Michael A. Shirley, Pat Wheelan, Stanley R. Howell and Robert C. Murphy
    Drug Metabolism and Disposition October 1997, 25 (10) 1144-1149;
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    Mechanism of Cytochrome P450 Activation by Caffeine and 7,8-Benzoflavone in Rat Liver Microsomes
    Caroline A. Lee, Peter T. Manyike, Kenneth E. Thummel, Sidney D. Nelson and John T. Slattery
    Drug Metabolism and Disposition October 1997, 25 (10) 1150-1156;
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    Bioactivation of the Anticancer Agent CPT-11 to SN-38 by Human Hepatic Microsomal Carboxylesterases and the in VitroAssessment of Potential Drug Interactions
    J. Greg Slatter, Ping Su, James P. Sams, Larry J. Schaaf and Larry C. Wienkers
    Drug Metabolism and Disposition October 1997, 25 (10) 1157-1164;
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    Pharmacokinetic Consequences of Induction of CYP2E1 by Ligand Stabilization
    Jenny Y. Chien, Kenneth E. Thummel and John T. Slattery
    Drug Metabolism and Disposition October 1997, 25 (10) 1165-1175;
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    The regiospecific hydroxylation of lauric acid by rainbow trout (oncorhynchus mykiss) cytochrome P450s
    Donald R. Buhler, Cristobal L. Miranda, Max L. Deinzer, Don A. Griffin and Marilyn C. Henderson
    Drug Metabolism and Disposition October 1997, 25 (10) 1176-1183;
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    Absorption, Disposition, and Metabolism oftrans-Methyl Styryl Ketone in Female B6C3F1 Mice
    John-Michael Sauer, Jingqi Bao, Richard L. Smith, Robert K. Kuester, Michael Mayersohn and I. Glenn Sipes
    Drug Metabolism and Disposition October 1997, 25 (10) 1184-1190;
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    In Vitro Metabolism of Simvastatin in Humans [sbt]Identification of metabolizing enzymes and effect of the drug on hepatic P450s
    Thomayant Prueksaritanont, Lynn M. Gorham, Bennett Ma, Lida Liu, Xiao Yu, Jianguo J. Zhao, Donald E. Slaughter, Byron H. Arison and Kamlesh P. Vyas
    Drug Metabolism and Disposition October 1997, 25 (10) 1191-1199;
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    The Rat Biliary Metabolites of Dihydroartemisinin, an Antimalarial Endoperoxide
    James L. Maggs, Stephen Madden, Laurence P. Bishop, Paul M. O’Neill and B. Kevin Park
    Drug Metabolism and Disposition October 1997, 25 (10) 1200-1204;
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    Purification and Characterization of a Canine Liver Phenol Sulfotransferase
    Elizabeth A. Oddy, Gary R. Manchee, Neil M. Freeman, Malcolm A. Ward and Michael W. H. Coughtrie
    Drug Metabolism and Disposition October 1997, 25 (10) 1205-1210;

Short Communications

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    Assessment of Potential Interactions Between Dopamine Receptor Agonists and Various Human Cytochrome P450 Enzymes Using a Simple In Vitro Inhibition Screen
    Michael A. Wynalda and Larry C. Wienkers
    Drug Metabolism and Disposition October 1997, 25 (10) 1211-1214;
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    Application of a First-Pass Effect Model to Characterize the Pharmacokinetic Disposition of Venlafaxine after Oral Administration to Human Subjects
    David R. Taft, Ganesh R. Iyer, Leon Behar and Robert V. Digregorio
    Drug Metabolism and Disposition October 1997, 25 (10) 1215-1218;
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    In Vitro Metabolism of Indinavir in the Human Fetal Liver Microsomes
    Masato Chiba, Joy A. Nshime and Jiunn H. Lin
    Drug Metabolism and Disposition October 1997, 25 (10) 1219-1222;
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In this issue

Drug Metabolism and Disposition
Vol. 25, Issue 10
1 Oct 1997
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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