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Glutathione-Dependent Conversion to Glyoxylate, a Major Pathway of Dichloroacetate Biotransformation in Hepatic Cytosol from Humans and Rats, is Reduced in Dichloroacetate-Treated Rats

M. O. James, R. Cornett, Z. Yan, G. N. Henderson and P. W. Stacpoole
Drug Metabolism and Disposition November 1997, 25 (11) 1223-1227;

Article Information

vol. 25 no. 11 1223-1227
PubMed 
9351896
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 18, 1997
  • Accepted July 8, 1997
  • Published online November 1, 1997.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. M. O. James1,
  2. R. Cornett1,
  3. Z. Yan1,2,
  4. G. N. Henderson2 and
  5. P. W. Stacpoole2,3
  1. 1Department of Medicinal Chemistry, College of Pharmacy (M.O.J., R.C.), 2Department of Medicine, Division of Endocrinology and Metabolism (Z.Y., G.N.H., P.W.S.) and 3Department of Biochemistry and Molecular Biology (P.W.S.), College of Medicine, University of Florida
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    Rapid CommunicationAccelerated Communication

    Glutathione-Dependent Conversion to Glyoxylate, a Major Pathway of Dichloroacetate Biotransformation in Hepatic Cytosol from Humans and Rats, is Reduced in Dichloroacetate-Treated Rats

    M. O. James, R. Cornett, Z. Yan, G. N. Henderson and P. W. Stacpoole
    Drug Metabolism and Disposition November 1, 1997, 25 (11) 1223-1227;
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