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Research ArticleArticle

Oral Bioavailability and First-Pass Effects

K. C. Kwan
Drug Metabolism and Disposition December 1997, 25 (12) 1329-1336;
K. C. Kwan
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This article has a correction. Please see:

  • Correction for vol. 25, p. 1329 - March 01, 1998

Abstract

Existing experimental strategies for the in vivoevaluation of factors affecting oral bioavailability have been reviewed. Based on concepts that have evolved, an integrated set of strategies emerges that appears capable of providing estimates of the individual contributions attributable to absorption, losses in the gut lumen, and first-pass elimination in the gut wall and the liver. The only assumptions are linear pharmacokinetics and constant clearance between treatments. These methods are also suitable for the assessment of metabolite bioavailability after drug administration and the quantitative determination of sites of biotransformation and metabolite formation in vivo.

Footnotes

  • Send reprint requests to: K. C. Kwan, Merck Research Laboratories, WP42-2, West Point, PA 19486.

    • Received December 23, 1996.
    • Accepted July 25, 1997.
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition
Vol. 25, Issue 12
1 Dec 1997
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Research ArticleArticle

Oral Bioavailability and First-Pass Effects

K. C. Kwan
Drug Metabolism and Disposition December 1, 1997, 25 (12) 1329-1336;

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Research ArticleArticle

Oral Bioavailability and First-Pass Effects

K. C. Kwan
Drug Metabolism and Disposition December 1, 1997, 25 (12) 1329-1336;
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