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Drug Metabolism & Disposition

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Table of Contents

February 01, 1997; Volume 25,Issue 2

Articles

  • You have access
    Diazepam Metabolism by cDNA-Expressed Human 2C P450s
    Frank Jung, Toby H. Richardson, Judy L. Raucy and Eric F. Johnson
    Drug Metabolism and Disposition February 1997, 25 (2) 133-139;
  • You have access
    Disposition and Metabolism of Tenidap in the Rat
    Hassan G. Fouda, Michael J. Avery, Deepak Dalvie, Fred C. Falkner, Lawrence S. Melvin and Robert A. Ronfeld
    Drug Metabolism and Disposition February 1997, 25 (2) 140-148;
  • You have access
    Comparison of in Vitro Carnitine and Glycine Conjugation with Branched-Side Chain and Cyclic Side Chain Carboxylic Acids in Rats
    Takushi Kanazu and Toshiro Yamaguchi
    Drug Metabolism and Disposition February 1997, 25 (2) 149-153;
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    Comparative Metabolism of the Tobacco-Related Carcinogens Benzo[a]pyrene, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone, 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanol, andN′-Nitrosonornicotine in Human Hepatic Microsomes
    Marianne E. Staretz, Sharon E. Murphy, Christopher J. Patten, Maria G. Nunes, Werner Koehl, Shantu Amin, Leeann A. Koenig, F. Peter Guengerich and Stephen S. Hecht
    Drug Metabolism and Disposition February 1997, 25 (2) 154-162;
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    Induction of Two UDP-Glucuronosyltransferase Isoforms Sensitive to Phenobarbital that are Involved in Morphine Glucuronidation
    Yuji Ishii, Atsuko Takami, Kazuoki Tsuruda, Akiko Kurogi, Hideyuki Yamada and Kazuta Oguri
    Drug Metabolism and Disposition February 1997, 25 (2) 163-167;
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    Effects of Freezing, Thawing, and Storage of Human Liver Samples on the Microsomal Contents and Activities of Cytochrome P450 Enzymes
    Hiroshi Yamazaki, Kiyoshi Inoue, Connie G. Turvy, F. Peter Guengerich and Tsutomu Shimada
    Drug Metabolism and Disposition February 1997, 25 (2) 168-174;
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    Human NAD(P)H:Quinone Oxidoreductase Induction in Human Hepatoma Cells after Exposure to Industrial Acrylates, Phenolics, and Metals
    Edward J. Winner, Russell A. Prough and Mark D. Brennan
    Drug Metabolism and Disposition February 1997, 25 (2) 175-181;
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    Short-Term Oral 3-Hydroxypyridin-4-one Dosing Increases Aluminum Excretion and Partially Reverses Aluminum-Induced Toxicity in the Rabbit Independent of Chelator Lipophilicity
    Robert A. Yokel, Kathryn A. Meurer, Chuen B. Hong, Kenneth M. Dickey, Thomas L. Skinner and Andrea M. Fredenburg
    Drug Metabolism and Disposition February 1997, 25 (2) 182-190;
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    In Vivo, Ex Vivo, and In Vitro Effects ofl-NAME and l-Arginine on the Metabolism of Theophylline in the Rabbit
    Mouhsine Barakat, Ayman O. S. El-Kadi and Patrick Du Souich
    Drug Metabolism and Disposition February 1997, 25 (2) 191-195;
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    Co-oxidative Metabolism of 4-Aminobiphenyl by Lipoxygenase from Soybean and Human Term Placenta
    Kaushik Datta, Paul M. Sherblom and Arun P. Kulkarni
    Drug Metabolism and Disposition February 1997, 25 (2) 196-105;
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    Metabolism and Excretion of the Novel Antipsychotic Drug Ziprasidone in Rats after Oral Administration of a Mixture of14C- and 3H-Labeled Ziprasidone
    Chandra Prakash, Amin Kamel, Wayne Anderson and Harry Howard
    Drug Metabolism and Disposition February 1997, 25 (2) 206-218;
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    A Comparative Investigation of 2-Propyl-4-Pentenoic Acid (4-ene VPA) and its α-Fluorinated Analogue: Phase II Metabolism and Pharmacokinetics
    Wei Tang and Frank S. Abbott
    Drug Metabolism and Disposition February 1997, 25 (2) 219-227;
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    Metabolism of the Human Immunodeficiency Virus Type 1 Reverse Transcriptase Inhibitor Delavirdine in Rats
    Mayland Chang, Virendra K. Sood, Gracella J. Wilson, David A. Kloosterman, Phillip E. Sanders, Michael J. Hauer and Paul E. Fagerness
    Drug Metabolism and Disposition February 1997, 25 (2) 228-242;
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    Metabolic Inactivation of Cytochrome P4502B1 by Phencyclidine
    Uma Sharma, Elizabeth S. Roberts, Ute M. Kent, S. Michael Owens and Paul F. Hollenberg
    Drug Metabolism and Disposition February 1997, 25 (2) 243-250;
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    Comparison of Stably Expressed Rat UGT1.1 and UGT2B1 in the Glucuronidation of Opioid Compounds
    Christopher D. King, Gladys R. Rios, Mitchell D. Green, Peter I. Mackenzie and Thomas R. Tephly
    Drug Metabolism and Disposition February 1997, 25 (2) 251-255;
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    Selective Biotransformation of the Human Immunodeficiency Virus Protease Inhibitor Saquinavir by Human Small-Intestinal Cytochrome P4503A4
    Michael E. Fitzsimmons and Jerry M. Collins
    Drug Metabolism and Disposition February 1997, 25 (2) 256-266;

Short Communications

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    Major Metabolic Pathway for N-Methyl-2-Pyrrolidone in Humans
    Bengt Åkesson and Bo A. g. Jönsson
    Drug Metabolism and Disposition February 1997, 25 (2) 267-269;
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    Lethal Drug Interactions of Sorivudine, a New Antiviral Drug, with Oral 5-Fluorouracil Prodrugs
    Haruhiro Okuda, Takahito Nishiyama, Kenichiro Ogura, Sekio Nagayama, Kazumasa Ikeda, Shuji Yamaguchi, Yoshimasa Nakamura, Yasuro Kawaguchi and Tadashi Watabe
    Drug Metabolism and Disposition February 1997, 25 (2) 270-273;
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Drug Metabolism and Disposition
Vol. 25, Issue 2
1 Feb 1997
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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