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Research ArticleArticle

Selective Biotransformation of the Human Immunodeficiency Virus Protease Inhibitor Saquinavir by Human Small-Intestinal Cytochrome P4503A4

Potential Contribution to High First-Pass Metabolism

Michael E. Fitzsimmons and Jerry M. Collins
Drug Metabolism and Disposition February 1997, 25 (2) 256-266;

Article Information

vol. 25 no. 2 256-266
PubMed 
9029057
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 12, 1996
  • Accepted November 19, 1996
  • Published online February 1, 1997.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Michael E. Fitzsimmons and
  2. Jerry M. Collins
  1. Laboratory of Clinical Pharmacology, Center for Drug Evaluation and Research, U.S. Food and Drug Administration
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    Research ArticleArticle

    Selective Biotransformation of the Human Immunodeficiency Virus Protease Inhibitor Saquinavir by Human Small-Intestinal Cytochrome P4503A4

    Michael E. Fitzsimmons and Jerry M. Collins
    Drug Metabolism and Disposition February 1, 1997, 25 (2) 256-266;
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