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Drug Metabolism & Disposition

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Table of Contents

June 01, 1997; Volume 25,Issue 6

Articles

  • You have access
    Metabolism of Selegiline in Humans
    Ho-Sang Shin
    Drug Metabolism and Disposition June 1997, 25 (6) 657-662;
  • You have access
    Biotransformation of the Novel Inotropic Agent Toborinone (OPC-18790) in Rats and Dogs
    Mami Kitani, Gohachiro Miyamoto, Masakazu Nagasawa, Toshihide Yamada, Jun Matsubara, Minoru Uchida and Masaaki Odomi
    Drug Metabolism and Disposition June 1997, 25 (6) 663-674;
  • You have access
    Prediction of Drug-Induced Catalepsy Based on Dopamine D1, D2, and Muscarinic Acetylcholine Receptor Occupancies
    Kaori Haraguchi, Kiyomi Ito, Hajime Kotaki, Yasufumi Sawada and Tatsuji Iga
    Drug Metabolism and Disposition June 1997, 25 (6) 675-684;
  • You have access
    Stereoselective Metabolism of rac-Mexiletine by the Fungus Cunninghamella echinulata Yields the Major Human Metabolites Hydroxymethylmexiletine andp-Hydroxymexiletine
    D. G. Freitag, R. T. Foster, R. T. Coutts, M. A. Pickard and F. M. Pasutto
    Drug Metabolism and Disposition June 1997, 25 (6) 685-692;
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    Metabolism and Disposition of the Antifolate LY231514 in Mice and Dogs
    J. M. Woodland, C. J. Barnett, D. E. Dorman, J. M. Gruber, C. Shih, L. A. Spangle, T. M. Wilson and W. J. Ehlhardt
    Drug Metabolism and Disposition June 1997, 25 (6) 693-700;
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    Disposition and metabolism of the Sulfonylurea Oncolytic Agent LY295501 in Mouse, Rat, and Monkey
    William J. Ehlhardt, Joseph M. Woodland, John E. Toth, James E. Ray and Diana L. Martin
    Drug Metabolism and Disposition June 1997, 25 (6) 701-708;
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    Microbial Models of Mammalian Metabolism
    Geeta P. Rao and Patrick J. Davis
    Drug Metabolism and Disposition June 1997, 25 (6) 709-715;
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    CYTOCHROME P450 RESPONSIBLE FOR THE STEREOSELECTIVES-OXIDATION OF FLOSEQUINAN IN HEPATIC MICROSOMES FROM RATS AND HUMANS
    Eiji Kashiyama, Tsuyoshi Yokoi, Masaaki Odomi, Yoshihiko Funae, Kazuaki Inoue and Tetsuya Kamataki
    Drug Metabolism and Disposition June 1997, 25 (6) 716-724;
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    Purification and 1H NMR Spectroscopic Characterization of Phase II Metabolites of Tolfenamic Acid
    Ulla Grove Sidelmann, Eyøhild Christiansen, Line Krogh, Claus Cornett and Jette Tjørnelund, and Steen Honoré Hansen
    Drug Metabolism and Disposition June 1997, 25 (6) 725-731;
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    Oral and Topical Absorption, Disposition Kinetics, and the Metabolic Fate of trans-Methyl Styryl Ketone in the Male Fischer 344 Rat
    John-Michael Sauer, Richard L. Smith, Jingqi Bao, Margaret J. Kattnig, Robert K. Kuester, Thomas D. McClure, Michael Mayersohn and I. Glenn Sipes
    Drug Metabolism and Disposition June 1997, 25 (6) 732-739;
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    Hydroxylation and Demethylation of the Tricyclic Antidepressant Nortriptyline by cDNA-Expressed Human Cytochrome P-450 Isozymes
    Ole V. Olesen and Kristian Linnet
    Drug Metabolism and Disposition June 1997, 25 (6) 740-744;
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    Baculovirus-Directed Expression of Rabbit UDP-Glucuronosyltransferases in Spodoptera frugiperda Cells
    Nghia Nguyen and Robert H. Tukey
    Drug Metabolism and Disposition June 1997, 25 (6) 745-749;
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    In Vivo Induction and in Vitro Inhibition of Hepatic Cytochrome P450 Activity by the Benzodiazepine Anticonvulsants Clonazepam and Diazepam
    Raymond W. Nims, Russell A. Prough, Collins R. Jones, Diana L. Stockus, Konstantin H. Dragnev, Paul E. Thomas and Ronald A. Lubet
    Drug Metabolism and Disposition June 1997, 25 (6) 750-756;
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    Induction of Cytochrome P4503A by the Antiglucocorticoid Mifepristone and a Novel Hypocholesterolaemic Drug
    J. Andrew Williams, Richard J. Chenery, Theo A. Berkhout and Gabrielle M. Hawksworth
    Drug Metabolism and Disposition June 1997, 25 (6) 757-761;
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    Inhibitory Anti-Peptide Antibody Against Human CYP3A4
    Regina W. Wang and Anthony Y. H. Lu
    Drug Metabolism and Disposition June 1997, 25 (6) 762-767;

Short Communications

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    Blood-Brain Barrier Permeability to Morphine-6-Glucuronide is Markedly Reduced Compared with Morphine
    Dafang Wu, Young-Sook Kang, Ulrich Bickel and William M. Pardridge
    Drug Metabolism and Disposition June 1997, 25 (6) 768-771;
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    Metabolism of Ketoconazole and Deacetylated Ketoconazole by Rat Hepatic Microsomes and Flavin-Containing Monooxygenases
    Rosita J. Rodriguez and Daniel Acosta
    Drug Metabolism and Disposition June 1997, 25 (6) 772-777;
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Drug Metabolism and Disposition
Vol. 25, Issue 6
1 Jun 1997
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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