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Drug Metabolism & Disposition

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Table of Contents

August 01, 1997; Volume 25,Issue 8

Articles

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    Scaling Factors to Relate Drug Metabolic Clearance in Hepatic Microsomes, Isolated Hepatocytes, and the Intact Liver
    David J. Carlile, Katayoun Zomorodi and J. Brian Houston
    Drug Metabolism and Disposition August 1997, 25 (8) 903-911;
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    Effects of Tauroursodeoxycholate Solutions on Cyclosporin A Bioavailability in Rats
    Nathalie Balandraud-Pieri, Pierre-Edouard Queneau, François-Xavier Caroli-Bosc, Pierre Bertault-Pérès, Anne-Marie Montet, Alain Durand and Jean-Claude Montet
    Drug Metabolism and Disposition August 1997, 25 (8) 912-916;
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    Pulmonary Delivery of Intratracheally Instilled and Aerosolized Cyclosporine A to Young and Adult Rats
    Witold Taljanski, Stefan G. Pierzynowski, Pal D. P. Lundin, Björn R. Weström, Stefan Eirefelt, Jerzy Podlesny, Magnus Dahlbäck, Henryka Siwinska-Golebiowska and Börje W. Karlsson
    Drug Metabolism and Disposition August 1997, 25 (8) 917-920;
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    Pharmacokinetics of a Potential Human Cytomegalovirus Therapeutic, a Phosphorothioate Oligonucleotide, After Intravitreal Injection in the Rabbit
    Janet M. Leeds, Scott P. Henry, Loanne Truong, Anup Zutshi, Arthur A. Levin and Doug Kornbrust
    Drug Metabolism and Disposition August 1997, 25 (8) 921-926;
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    STABILITY OF COMMERCIAL FORMULATIONS AND AQUEOUS SOLUTIONS OF IFOSFAMIDE
    Veronique Gilard, Robert Martino, Myriam Malet-Martino and Ulf Niemeyer
    Drug Metabolism and Disposition August 1997, 25 (8) 927-931;
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    Orally Active Inhibitors Of Human Leukocyte Elastase. II. Disposition of L-694,458 in Rats and Rhesus Monkeys
    Styliani H. Vincent, Susan K. Painter, Debra Luffer-Atlas, Bindhu V. Karanam, E. McGowan, Chris Cioffe, George Doss and Shuet-Hing L. Chiu
    Drug Metabolism and Disposition August 1997, 25 (8) 932-939;
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    Orally Active Inhibitors Of Human Leukocyte Elastase. III. Identification and Characterization of Metabolites of l-694,458 by Liquid Chromatography-Tandem Mass Spectrometry
    Debra Luffer-Atlas, Styliani H. Vincent, Susan K. Painter, Byron H. Arison, Ralph A. Stearns and Shuet-Hing Lee Chiu
    Drug Metabolism and Disposition August 1997, 25 (8) 940-952;
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    Characterization of Carbamazepine Metabolism in a Mouse Model of Carbamazepine Teratogenicity
    Benny M. Amore, Thomas F. Kalhorn, Gary L. Skiles, Ann P. Hunter, Greg D. Bennett, Richard H. Finnell, Sidney D. Nelson and John T. Slattery
    Drug Metabolism and Disposition August 1997, 25 (8) 953-962;
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    Isolation and Identification of Major Urinary Metabolites of Rifabutin in Rats and Humans
    Ilya Utkin, Tatiana Koudriakova, Toni Thompson, Charles Cottrell, Eugenia Iatsimirskaia, John Barry, Paul Vouros and Nicholas Gerber
    Drug Metabolism and Disposition August 1997, 25 (8) 963-969;
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    In vitro Identification of the Human Cytochrome P450 Enzymes Involved in the Metabolism of R(+)- and S(−)-Carvedilol
    Harriet G. Oldham and Stephen E. Clarke
    Drug Metabolism and Disposition August 1997, 25 (8) 970-977;
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    In Vitro and In Vivo Evaluations of the Metabolism, Pharmacokinetics, and Bioavailability of Ester Prodrugs ofl-767,679, A Potent Fibrinogen Receptor Antagonist
    Thomayant Prueksaritanont, Lynn M. Gorham, Michael J. Breslin, John H. Hutchinson, George D. Hartman, Kamlesh P. Vyas and Thomas A. Baillie
    Drug Metabolism and Disposition August 1997, 25 (8) 978-984;
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    Human Cytochrome P4502B6
    Erin L. Code, Charles L. Crespi, Bruce W. Penman, Frank J. Gonzalez, Thomas K. H. Chang and David J. Waxman
    Drug Metabolism and Disposition August 1997, 25 (8) 985-993;
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    Effect of Ovariectomy and Androgen on Phenobarbital Induction of Hepatic CYP2B1 and CYP2B2 in Sprague-Dawley Rats
    Thomas K. H. Chang, Mellissa D. Anderson, Stelvio M. Bandiera and Gail D. Bellward
    Drug Metabolism and Disposition August 1997, 25 (8) 994-1000;
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    Characterization of Two Human Flavin-Containing Monooxygenase (Form 3) Enzymes Expressed in Escherichia coli as Maltose Binding Protein Fusions
    Alan Brunelle, Yi-An Bi, Jing Lin, Brett Russell, Lisa Luy, Clifford Berkman and John Cashman
    Drug Metabolism and Disposition August 1997, 25 (8) 1001-1007;
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    Improved Separation and Immunodetection of Rat Cytochrome P450 4A Forms in Liver and Kidney
    Janice Rice Okita, Steven B. Johnson, Pamela J. Castle, Sheryl C. Dezellem and Richard T. Okita
    Drug Metabolism and Disposition August 1997, 25 (8) 1008-1012;

Short Communication

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    Epoxide Hydrolase-Dependent Metabolism of Butadiene Monoxide to 3-Butene-1,2-diol in Mouse, Rat, and Human Liver
    Renee J. Krause, Jane E. Sharer and Adnan A. Elfarra
    Drug Metabolism and Disposition August 1997, 25 (8) 1013-1015;

Erratum

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    Erratum for Rao and Davis, Drug Metab Dispos 25 (6) 709-715.
    Drug Metabolism and Disposition August 1997, 25 (8) 1016;
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Drug Metabolism and Disposition
Vol. 25, Issue 8
1 Aug 1997
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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