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Drug Metabolism & Disposition

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Table of Contents

November 01, 1998; Volume 26,Issue 11

Articles

  • You have access
    Comparative Studies of In Vitro Inhibition of Cytochrome P450 3A4-Dependent Testosterone 6β-Hydroxylation by Roxithromycin and Its Metabolites, Troleandomycin, and Erythromycin
    Hiroshi Yamazaki and Tsutomu Shimada
    Drug Metabolism and Disposition November 1998, 26 (11) 1053-1057;
  • You have access
    Tissue Distribution, Metabolism, and Clearance of the Convulsant Trimethylolpropane Phosphate in Rats
    John Rossi, Anne E. Jung, Glenn D. Ritchie, James W. Lindsey and Alan F. Nordholm
    Drug Metabolism and Disposition November 1998, 26 (11) 1058-1062;
  • You have access
    Alterations of the Catalytic Activities of Drug-Metabolizing Enzymes in Cultures of Human Liver Slices
    Mark VandenBranden, Steven A. Wrighton, Sean Ekins, Jennifer S. Gillespie, Shelly N. Binkley, Barbara J. Ring, Melinda G. Gadberry, D. Charlene Mullins, Stephen C. Strom and Charles B. Jensen
    Drug Metabolism and Disposition November 1998, 26 (11) 1063-1068;
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    Metabolism and Excretion of Zafirlukast in Dogs, Rats, and Mice
    R. D. Savidge, K. H. Bui, B. K. Birmingham, J. L. Morse and R. C. Spreen
    Drug Metabolism and Disposition November 1998, 26 (11) 1069-1076;
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    Pharmacokinetics of the Bicyclic Peptide Tachykinin NK2 Receptor Antagonist MEN 11420 (Nepadutant) in Rats
    Annalisa Lippi, Marco Criscuoli, Marco Guelfi, Paolo Santicioli and Carlo Alberto Maggi
    Drug Metabolism and Disposition November 1998, 26 (11) 1077-1081;
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    Effects of Fibrates on the Glycine Conjugation of Benzoic Acid in Rats
    Zoltán Gregus, Tibor Fekete, Éva Halászi, Ágnes Gyurasics and Curtis D. Klaassen
    Drug Metabolism and Disposition November 1998, 26 (11) 1082-1088;
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    Potentially Reactive Cyclic Carbamate Metabolite of the Antiepileptic Drug Felbamate Produced by Human Liver Tissue In Vitro
    Izet M. Kapetanovic, Cynthia D. Torchin, Charles D. Thompson, Thomas A. Miller, Patrick J. McNeilly, Timothy L. Macdonald, Harvey J. Kupferberg, James L. Perhach, R. Duane Sofia and John M. Strong
    Drug Metabolism and Disposition November 1998, 26 (11) 1089-1095;
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    1- and 3-Hydroxylations, in Addition to 4-Hydroxylation, of Debrisoquine Are Catalyzed by Cytochrome P450 2D6 in Humans
    Birgit Eiermann, Per Olof Edlund, Agneta Tjernberg, Per Dalén, Marja-Liisa Dahl and Leif Bertilsson
    Drug Metabolism and Disposition November 1998, 26 (11) 1096-1101;
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    In Vitro and In Vivo Metabolism of the Progestagen Org 30659 in Several Species
    C. H. J. Verhoeven, S. F. M. Krebbers, G. N. Wagenaars, C. J. Booy, G. M. M. Groothuis, P. Olinga and R. M. E. Vos
    Drug Metabolism and Disposition November 1998, 26 (11) 1102-1112;
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    Hepatobiliary Transport Kinetics of HSR-903, a New Quinolone Antibacterial Agent
    Mitsuo Murata, Ikumi Tamai, Yoshimichi Sai, Osamu Nagata, Hideo Kato, Yuichi Sugiyama and Akira Tsuji
    Drug Metabolism and Disposition November 1998, 26 (11) 1113-1119;
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    Predicting the Oral Bioavailability of 19-Nortestosterone Progestins In Vivo from Their Metabolic Stability in Human Liver Microsomal Preparations In Vitro
    Wilhelm Kuhnz and Hille Gieschen
    Drug Metabolism and Disposition November 1998, 26 (11) 1120-1127;
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    Dose-Dependent Effects of PSC 833 on Its Tissue Distribution and on the Biliary Excretion of Endogenous Substrates in Rats
    SaeHeum Song, Hiroshi Suzuki, Ryosei Kawai, Chiaki Tanaka, Izumi Akasaka and Yuichi Sugiyama
    Drug Metabolism and Disposition November 1998, 26 (11) 1128-1133;
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    Pharmacokinetics and Metabolism of [14C]Dichloroacetate in Male Sprague-Dawley Rats
    Margaret O. James, Zimeng Yan, Rachel Cornett, V. Murali K. M. Jayanti, George N. Henderson, Natalia Davydova, Michael J. Katovich, Brad Pollock and Peter W. Stacpoole
    Drug Metabolism and Disposition November 1998, 26 (11) 1134-1143;
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    Transport of the β-Lactam Antibiotic Benzylpenicillin and the Dipeptide Glycylsarcosine by Brain Capillary Endothelial Cells In Vitro
    Michael Török, Jörg Huwyler, Jürgen Drewe, Heike Gutmann and Gert Fricker
    Drug Metabolism and Disposition November 1998, 26 (11) 1144-1148;
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    Tissue Distribution and Biotransformation of Zopolrestat, an Aldose Reductase Inhibitor, in Rats
    Richard P. Schneider, Hassan G. Fouda and Philip B. Inskeep
    Drug Metabolism and Disposition November 1998, 26 (11) 1149-1159;
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    Bioavailability, Multiple-Dose Pharmacokinetics, and Biotransformation of the Aldose Reductase Inhibitor Zopolrestat in Dogs
    Richard P. Schneider, Cynthia J. Davenport, Keith A. Hoffmaster and Philip B. Inskeep
    Drug Metabolism and Disposition November 1998, 26 (11) 1160-1166;
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Drug Metabolism and Disposition
Vol. 26, Issue 11
1 Nov 1998
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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