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Research ArticleArticle

Metabolism of the Human Immunodeficiency Virus Protease Inhibitors Indinavir and Ritonavir by Human Intestinal Microsomes and Expressed Cytochrome P4503A4/3A5: Mechanism-Based Inactivation of Cytochrome P4503A by Ritonavir

Tatiana Koudriakova, Eugenia Iatsimirskaia, Ilya Utkin, Eric Gangl, Paul Vouros, Elena Storozhuk, Daniela Orza, Julia Marinina and Nicholas Gerber
Drug Metabolism and Disposition June 1998, 26 (6) 552-561;
Tatiana Koudriakova
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Eugenia Iatsimirskaia
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Ilya Utkin
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Eric Gangl
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Paul Vouros
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Elena Storozhuk
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Daniela Orza
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Julia Marinina
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Nicholas Gerber
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Article Information

vol. 26 no. 6 552-561
PubMed 
9616191

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 31, 1997
  • Accepted February 26, 1998
  • Published online June 1, 1998.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tatiana Koudriakova1,
  2. Eugenia Iatsimirskaia1,
  3. Ilya Utkin1,
  4. Eric Gangl2,
  5. Paul Vouros2,
  6. Elena Storozhuk1,
  7. Daniela Orza1,
  8. Julia Marinina1 and
  9. Nicholas Gerber1
  1. 1Department of Pharmacology, The Ohio State University (T.K., E.I., I.U., E.S., D.O., J.M., N.G.), and 2Department of Chemistry, Northeastern University (E.G., P.V.)
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    Drug Metabolism and Disposition
    Vol. 26, Issue 6
    1 Jun 1998
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    Research ArticleArticle

    Metabolism of the Human Immunodeficiency Virus Protease Inhibitors Indinavir and Ritonavir by Human Intestinal Microsomes and Expressed Cytochrome P4503A4/3A5: Mechanism-Based Inactivation of Cytochrome P4503A by Ritonavir

    Tatiana Koudriakova, Eugenia Iatsimirskaia, Ilya Utkin, Eric Gangl, Paul Vouros, Elena Storozhuk, Daniela Orza, Julia Marinina and Nicholas Gerber
    Drug Metabolism and Disposition June 1, 1998, 26 (6) 552-561;

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    Research ArticleArticle

    Metabolism of the Human Immunodeficiency Virus Protease Inhibitors Indinavir and Ritonavir by Human Intestinal Microsomes and Expressed Cytochrome P4503A4/3A5: Mechanism-Based Inactivation of Cytochrome P4503A by Ritonavir

    Tatiana Koudriakova, Eugenia Iatsimirskaia, Ilya Utkin, Eric Gangl, Paul Vouros, Elena Storozhuk, Daniela Orza, Julia Marinina and Nicholas Gerber
    Drug Metabolism and Disposition June 1, 1998, 26 (6) 552-561;
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