Abstract
Bromfenac (Duract®), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside.
Footnotes
-
Send reprint requests to: Sandra Kirkman Gonzales, Wyeth-Ayerst Research, CN 8000, Princeton, NJ 08543.
- Abbreviations used are::
- TMS-glucose
- trimethylsilylglucose
- HPLC
- high-performance liquid chromatography
- LC/MS
- liquid chromatography/mass spectrometry
- GC/MS
- gas chromatography/mass spectrometry
- ESI
- electrospray ionization
- CI
- chemical ionization
- CID
- collision-induced dissociation
- 5-ASA
- 5-aminosalicylic acid
- Received August 13, 1997.
- Accepted May 19, 1998.
- The American Society for Pharmacology and Experimental Therapeutics
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Isolation and Identification of Bromfenac Glucoside From Rat Bile
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