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Rapid CommunicationShort Communication

Isolation and Identification of Bromfenac Glucoside From Rat Bile

Sandra K. Kirkman, Mei-Yi Zhang, Peter M. Horwatt and JoAnn Scatina
Drug Metabolism and Disposition July 1998, 26 (7) 720-723;
Sandra K. Kirkman
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Mei-Yi Zhang
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Peter M. Horwatt
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JoAnn Scatina
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Abstract

Bromfenac (Duract®), a drug approved for pain, was expected to be metabolized by the rat to an acyl glucuronide, a metabolite formed with most compounds of similar structure. During the investigation of metabolite profiles in rat bile following administration of 1 mg/kg iv doses of14C-bromfenac, an acid-labile metabolite was found that degraded to form 14C-bromfenac. Isolation and characterization of this metabolite indicated that it is an unusual conjugate, bromfenac N-glucoside.

Footnotes

  • Send reprint requests to: Sandra Kirkman Gonzales, Wyeth-Ayerst Research, CN 8000, Princeton, NJ 08543.

  • Abbreviations used are::
    TMS-glucose
    trimethylsilylglucose
    HPLC
    high-performance liquid chromatography
    LC/MS
    liquid chromatography/mass spectrometry
    GC/MS
    gas chromatography/mass spectrometry
    ESI
    electrospray ionization
    CI
    chemical ionization
    CID
    collision-induced dissociation
    5-ASA
    5-aminosalicylic acid
    • Received August 13, 1997.
    • Accepted May 19, 1998.
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition
Vol. 26, Issue 7
1 Jul 1998
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Rapid CommunicationShort Communication

Isolation and Identification of Bromfenac Glucoside From Rat Bile

Sandra K. Kirkman, Mei-Yi Zhang, Peter M. Horwatt and JoAnn Scatina
Drug Metabolism and Disposition July 1, 1998, 26 (7) 720-723;

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Rapid CommunicationShort Communication

Isolation and Identification of Bromfenac Glucoside From Rat Bile

Sandra K. Kirkman, Mei-Yi Zhang, Peter M. Horwatt and JoAnn Scatina
Drug Metabolism and Disposition July 1, 1998, 26 (7) 720-723;
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