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Drug Metabolism & Disposition

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Table of Contents

August 01, 1998; Volume 26,Issue 8

Articles

  • You have access
    Disposition and Metabolism of Rifapentine, a Rifamycin Antibiotic, in Mice, Rats, and Monkeys
    W. Bart Emary, Paul C. Toren, Brad Mathews and Kay Huh
    Drug Metabolism and Disposition August 1998, 26 (8) 725-731;
  • You have access
    Disposition and Metabolism of14C-Rifapentine in Healthy Volunteers
    Kelly Reith, Anther Keung, Paul C. Toren, Lawrence Cheng, Mark G. Eller and Scott J. Weir
    Drug Metabolism and Disposition August 1998, 26 (8) 732-738;
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    Gender Differences in N-Alkyl Protoporphyrin IX Production in Rats after the Administration of Porphyrinogenic Xenobiotics
    Simon G.W. Wong, Susan M. Kobus, James P. McNamee and Gerald S. Marks
    Drug Metabolism and Disposition August 1998, 26 (8) 739-744;
  • You have access
    The Pharmacokinetics of a New Antiglaucoma Drug, Latanoprost, in the Rabbit
    B. Sjöquist, S. Basu, P. Byding, K. Bergh and J. Stjernschantz
    Drug Metabolism and Disposition August 1998, 26 (8) 745-754;
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    Metabolism and Excretion Studies in Mouse After Single and Multiple Oral Doses of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitor Atorvastatin
    Ann E. Black, Michael W. Sinz, Roger N. Hayes and Thomas F. Woolf
    Drug Metabolism and Disposition August 1998, 26 (8) 755-763;
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    Cytochrome P4502D6 Catalyzes the O-Demethylation of the Psychoactive Alkaloid Ibogaine to 12-Hydroxyibogamine
    R. Scott Obach, John Pablo and Deborah C. Mash
    Drug Metabolism and Disposition August 1998, 26 (8) 764-768;
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    Biosynthesis of an Aminopiperidino Metabolite of Irinotecan [7-Ethyl-10-[4-(1-piperidino)-1-piperidino]carbonyloxycamptothecine] by Human Hepatic Microsomes
    Marie-Christine Haaz, Christian Riché, Laurent P. Rivory and Jacques Robert
    Drug Metabolism and Disposition August 1998, 26 (8) 769-774;
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    Human N-Demethylation of (S)-Mephenytoin by Cytochrome P450s 2C9 and 2B6
    Jae-Wook Ko, Zeruesenay Desta and David A. Flockhart
    Drug Metabolism and Disposition August 1998, 26 (8) 775-778;
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    Species- and Sex-Related Differences in Metabolism of Trichloroethylene To Yield Chloral and Trichloroethanol in Mouse, Rat, and Human Liver Microsomes
    Adnan A. Elfarra, Renee J. Krause, Allen R. Last, Lawrence H. Lash and Jean C. Parker
    Drug Metabolism and Disposition August 1998, 26 (8) 779-785;
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    Metabolism of3H/14C-Labeled 4"-Deoxy-4"-epimethylaminoavermectin B1aBenzoate in Chickens
    Christopher L. Wrzesinski, Mohammad Mushtaq, Terry Faidley, Nelson Johnson, Byron Arison and Louis S. Crouch
    Drug Metabolism and Disposition August 1998, 26 (8) 786-794;
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    Differential Regulation of Individual Sulfotransferase Isoforms by Phenobarbital in Male Rat Liver
    Melissa Runge-Morris, Kelly Rose, Charles N. Falany and Thomas A. Kocarek
    Drug Metabolism and Disposition August 1998, 26 (8) 795-801;
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    The Multidrug Resistance Modulator Valspodar (PSC 833) Is Metabolized by Human Cytochrome P450 3A
    Volker Fischer, Alicia Rodríguez-Gascón, Francis Heitz, Ronald Tynes, Christian Hauck, Dalia Cohen and Alison E. M. Vickers
    Drug Metabolism and Disposition August 1998, 26 (8) 802-811;
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    Interaction of Periodate-Oxidized UDP-Glucuronic Acid with Recombinant Human Liver UDP-Glucuronosyltransferase 1A6
    Eric Battaglia, Nadege Terrier, Magdalena Mizeracka, Claire Senay, Jacques Magdalou, Sylvie Fournel-Gigleux and Anna Radominska-Pandya
    Drug Metabolism and Disposition August 1998, 26 (8) 812-817;

Short Communications

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    Human Buprenorphine N-Dealkylation Is Catalyzed by Cytochrome P450 3A4
    Kaoru Kobayashi, Toshinori Yamamoto, Kan Chiba, Masayoshi Tani, Noriaki Shimada, Takashi Ishizaki and Yukio Kuroiwa
    Drug Metabolism and Disposition August 1998, 26 (8) 818-821;
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    Differential Xenobiotic Induction of CYP2A5 in Mouse Liver, Kidney, Lung, and Olfactory Mucosa
    Ting Su, Wenlei He, Jun Gu, Thomas W. Lipinskas and Xinxin Ding
    Drug Metabolism and Disposition August 1998, 26 (8) 822-824;
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    Covalent Binding of 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline to Albumin and Hemoglobin at Environmentally Relevant Doses
    Karen H. Dingley, Stewart P. H. T. Freeman, David O. Nelson, R. Colin Garner and Kenneth W. Turteltaub
    Drug Metabolism and Disposition August 1998, 26 (8) 825-828;
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In this issue

Drug Metabolism and Disposition
Vol. 26, Issue 8
1 Aug 1998
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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