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Drug Metabolism & Disposition

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Table of Contents

January 01, 1999; Volume 27,Issue 1

Review

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    Toxicokinetics of 2′,3′-Didehydro-3′-Deoxythymidine, Stavudine (D4T)
    Sanjeev Kaul, Kishor A. Dandekar, Beth E. Schilling and Rashmi H. Barbhaiya
    Drug Metabolism and Disposition January 1999, 27 (1) 1-12;

Articles

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    Disposition and Pharmacokinetics of Phenethyl Isothiocyanate and 6-Phenylhexyl Isothiocyanate in F344 Rats
    C. Clifford Conaway, Ding Jiao, Toshiyuki Kohri, Leonard Liebes and Fung-Lung Chung
    Drug Metabolism and Disposition January 1999, 27 (1) 13-20;
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    Animal Pharmacokinetics of the Tumor Necrosis Factor Receptor-Immunoglobulin Fusion Protein Lenercept and Their Extrapolation to Humans
    Wolfgang F. Richter, Harald Gallati and Claus-Dieter Schiller
    Drug Metabolism and Disposition January 1999, 27 (1) 21-25;
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    Glucuronidation of R- andS-Ketoprofen, Acetaminophen, and Diflunisal by Liver Microsomes of Adjuvant-Induced Arthritic Rats
    Christine J. Meunier and Roger K. Verbeeck
    Drug Metabolism and Disposition January 1999, 27 (1) 26-31;
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    Rapid Liquid Chromatography with Tandem Mass Spectrometry-Based Screening Procedures for Studies on the Biotransformation of Drug Candidates
    C. L. Fernández-Metzler, K. G. Owens*, T. A. Baillie and R. C. King
    Drug Metabolism and Disposition January 1999, 27 (1) 32-40;
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    Nonlinear Pharmacokinetics of Efavirenz (DMP-266), a Potent HIV-1 Reverse Transcriptase Inhibitor, in Rats and Monkeys
    Suresh K. Balani, Laura R. Kauffman, Florencia A. deLuna and Jiunn H. Lin
    Drug Metabolism and Disposition January 1999, 27 (1) 41-45;
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    Species and Sex Differences in Expression of Flavin-Containing Monooxygenase Form 3 in Liver and Kidney Microsomes
    Sharon L. Ripp, Kiyoshi Itagaki, Richard M. Philpot and Adnan A. Elfarra
    Drug Metabolism and Disposition January 1999, 27 (1) 46-52;
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    EDTA-Resistant and Sensitive Phosphotriesterase Activities Associated with Albumin and Lipoproteins in Rabbit Serum
    Miguel A. Sogorb, Inés Sánchez, Manuel López-Rivadulla, Virtudes Céspedes and Eugenio Vilanova
    Drug Metabolism and Disposition January 1999, 27 (1) 53-59;
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    Aldose Reductase Catalyzes the Oxidation of Naphthalene-1,2-Dihydrodiol for the Formation ofOrtho-Naphthoquinone
    Katsumi Sugiyama, Tao-Chin Lin Wang, John T. Simpson, Libaniel Rodriguez, Peter F. Kador and Sanai Sato
    Drug Metabolism and Disposition January 1999, 27 (1) 60-67;
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    Diminished CYP2E1 Expression and Formation of 2-S-Glutathionyl Acetate, a Glutathione Conjugate Derived from 1,1-Dichloroethylene Epoxide, in Murine Lung Tumors
    Poh-Gek Forkert, Alvin M. Malkinson, Pamela Rice and Madeleine Moussa
    Drug Metabolism and Disposition January 1999, 27 (1) 68-73;
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    Metabolic Disposition of a Monoterpene Ketone, Piperitenone, in Rats: Evidence for the Formation of a Known Toxin,p-cresol
    K. Madhava Madyastha and Nilesh W. Gaikwad
    Drug Metabolism and Disposition January 1999, 27 (1) 74-80;
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    Role of Plasma Protein Binding on Renal Metabolism and Dynamics of Furosemide in the Rabbit
    Vincent Pichette, David Geadah and Patrick du Souich
    Drug Metabolism and Disposition January 1999, 27 (1) 81-85;
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    In Vitro Metabolism of the HIV-1 Protease Inhibitor ABT-378: Species Comparison and Metabolite Identification
    Gondi N. Kumar, Venkata Jayanti, Ronald D. Lee, David N. Whittern, John Uchic, Samuel Thomas, Paulette Johnson, Brian Grabowski, Hing Sham, David Betebenner, Dale J. Kempf and Jon F. Denissen
    Drug Metabolism and Disposition January 1999, 27 (1) 86-91;
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    A Unique Tertiary Amine N-Oxide Reduction System Composed of Quinone Reductase and Heme in Rat Liver Preparations
    Shigeyuki Kitamura, Kazumi Sugihara and Kiyoshi Tatsumi
    Drug Metabolism and Disposition January 1999, 27 (1) 92-97;
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    Detection of a Novel Cytochrome P-450 1A2 polymorphism (F21L) in Chinese
    Jin-ding Huang, Wei-Chung Guo, Ming-Derg Lai, Yueleong Leon Guo and George H. Lambert
    Drug Metabolism and Disposition January 1999, 27 (1) 98-101;
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    Eight Inhibitory Monoclonal Antibodies Define the Role of Individual P-450s in Human Liver Microsomal Diazepam, 7-Ethoxycoumarin, and Imipramine Metabolism
    Tian J. Yang, Kristopher W. Krausz, Yang Sai, Frank J. Gonzalez and Harry V. Gelboin
    Drug Metabolism and Disposition January 1999, 27 (1) 102-109;
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    Heterogeneity in Systemic Availability of Ondansetron and Granisetron following Oral Administration
    B. W. Corrigan, B. Nicholls, B. Thakrar, R. Lam, C. Grosse, J. Alianti and J. L. Palmer
    Drug Metabolism and Disposition January 1999, 27 (1) 110-112;
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    First-Pass Disposition of (−)-6-Aminocarbovir in Rats. I. Prodrug Activation May Be Limited by Access to Enzyme
    Yandong Wen, Rory P. Remmel and Cheryl L. Zimmerman
    Drug Metabolism and Disposition January 1999, 27 (1) 113-121;
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    Prolactin Increases the Hepatic Content of μ-Class Subunits of Glutathione S-Transferase in the Rat
    Marcelo G. Luquita, Viviana A. Catania, Enrique J. Sánchez-Pozzi, Mary Vore and Aldo D. Mottino
    Drug Metabolism and Disposition January 1999, 27 (1) 122-124;
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    In Vitro Metabolism of the M1-Muscarinic Agonist 5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine by Human Hepatic Cytochromes P-450 Determined at pH 7.4 and 8.5
    Klaus Gjervig Jensen and Lars Dalgaard
    Drug Metabolism and Disposition January 1999, 27 (1) 125-132;
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    Inhibition of Human Aldehyde Dehydrogenase 1 by the 4-Hydroxycyclophosphamide Degradation Product Acrolein
    Song Ren, Thomas F. Kalhorn and John T. Slattery
    Drug Metabolism and Disposition January 1999, 27 (1) 133-137;
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    Comparative Metabolism and Disposition of Gemfibrozil in Male and Female Sprague-Dawley Rats and Syrian golden Hamsters
    Kelly J. Dix, Donna P. Coleman and A. Robert Jeffcoat
    Drug Metabolism and Disposition January 1999, 27 (1) 138-146;
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    Isolation and identification of novel metabolites of gemfibrozil in rat urine
    Brian F. Thomas, Jason P. Burgess, Donna P. Coleman, Nicole M. Scheffler, A. Robert Jeffcoat and Kelly J. Dix
    Drug Metabolism and Disposition January 1999, 27 (1) 147-157;

Short Communication

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    In Vivo Studies on Chiral Inversion and Amino Acid Conjugation of 2-[4-(3-Methyl-2-thienyl)phenyl]propionic Acid in Rats and Dogs
    Tadao Konishi, Hitoshi Nishikawa, Shigeyuki Kitamura and Kiyoshi Tatsumi
    Drug Metabolism and Disposition January 1999, 27 (1) 158-160;
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Drug Metabolism and Disposition: 27 (1)
Drug Metabolism and Disposition
Vol. 27, Issue 1
1 Jan 1999
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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