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Drug Metabolism & Disposition

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Table of Contents

November 01, 1999; Volume 27,Issue 11

Articles

  • You have access
    Correlation between In Vivo and In Vitro Hepatic Uptake of Metabolic Inhibitors of Cytochrome P-450 in Rats
    Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Sayuri Takedomi, Hirotami Matsuo, Yasufumi Sawada and Tatsuji Iga
    Drug Metabolism and Disposition November 1999, 27 (11) 1225-1231;
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    Preclinical Pharmacokinetics and Interspecies Scaling of a Novel Vitronectin Receptor Antagonist
    Keith W. Ward, Leonard M. Azzarano, William E. Bondinell, Russell D. Cousins, William F. Huffman, Dalia R. Jakas, Richard M. Keenan, Thomas W. Ku, Dave Lundberg, William H. Miller, Jayme A. Mumaw, Kenneth A. Newlander, Jill L. Pirhalla, Theresa J. Roethke, Kevin L. Salyers, Pamela R. Souder, Gary J. Stelman and Brian R. Smith
    Drug Metabolism and Disposition November 1999, 27 (11) 1232-1241;
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    Effect of a Ligand Selective for Peripheral Benzodiazepine Receptors on the Expression of Rat Hepatic P-450 Cytochromes: Assessment of the Effect In Vivo and in a Hepatocyte Culture System
    Hideyuki Yamada, Yumie Matsuki, Tohru Yamaguchi and Kazuta Oguri
    Drug Metabolism and Disposition November 1999, 27 (11) 1242-1247;
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    Direct Detection of Antipyrine Metabolites in Rat Urine by13C Labeling and NMR Spectroscopy
    Kazuki Akira, Eiji Negishi, Chiseko Sakuma and Takao Hashimoto
    Drug Metabolism and Disposition November 1999, 27 (11) 1248-1253;
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    Identification of Human Cytochrome P-450 Isoforms Involved in Metabolism of R(+)- and S(−)-Gallopamil: Utility of In Vitro Disappearance Rate
    Akio Suzuki, Izumi Iida, Fumie Tanaka, Masayuki Akimoto, Kiyomi Fukushima, Masayoshi Tani, Takashi Ishizaki and Kan Chiba
    Drug Metabolism and Disposition November 1999, 27 (11) 1254-1259;
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    Oxidation of Troglitazone to a Quinone-Type Metabolite Catalyzed by Cytochrome P-450 2C8 and P-450 3A4 in Human Liver Microsomes
    Hiroshi Yamazaki, Ayaka Shibata, Mikie Suzuki, Miki Nakajima, Noriaki Shimada, F. Peter Guengerich and Tsuyoshi Yokoi
    Drug Metabolism and Disposition November 1999, 27 (11) 1260-1266;
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    Identification of Metabolites of Octamethylcyclotetrasiloxane (D4) in Rat Urine
    Sudarsanan Varaprath, Kevin L. Salyers, Kathleen P. Plotzke and Shrenik Nanavati
    Drug Metabolism and Disposition November 1999, 27 (11) 1267-1273;
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    Prediction of Human Liver Microsomal Oxidations of 7-Ethoxycoumarin and Chlorzoxazone with Kinetic Parameters of Recombinant Cytochrome P-450 Enzymes
    Tsutomu Shimada, Fujiko Tsumura and Hiroshi Yamazaki
    Drug Metabolism and Disposition November 1999, 27 (11) 1274-1280;
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    Conjugation of the Enantiomers of Ketotifen to Four Isomeric Quaternary Ammonium Glucuronides in Humans In Vivo and in Liver Microsomes
    Udo Mey, Helmut Wachsmuth and Ursula Breyer-Pfaff
    Drug Metabolism and Disposition November 1999, 27 (11) 1281-1292;
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    Propofol Hydroxylation by Dog Liver Microsomes: Assay Development and Dog Breed Differences
    Michael H. Court, Bonnie L. Hay-Kraus, Dennis W. Hill, Albert J. Kind and David J. Greenblatt
    Drug Metabolism and Disposition November 1999, 27 (11) 1293-1299;
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    Disposition of [G-3H]paclitaxel and Cremophor EL in a Patient with Severely Impaired Renal Function
    Hans Gelderblom, Jaap Verweij, Eric Brouwer, Marrimuthoo Pillay, Peter de Bruijn, Kees Nooter, Gerrit Stoter and Alex Sparreboom
    Drug Metabolism and Disposition November 1999, 27 (11) 1300-1305;
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    Catalysis of Drug Oxidation during Embryogenesis in Human Hepatic Tissues using Imipramine as a Model Substrate
    Hao Chen, Monica R. Brzezinski, Alan G. Fantel and Mont R. Juchau
    Drug Metabolism and Disposition November 1999, 27 (11) 1306-1308;
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    Stereoselective Metabolism of Ifosfamide by Human P-450s 3A4 and 2B6. Favorable Metabolic Properties of R-Enantiomer
    Partha Roy, Olga Tretyakov, Joel Wright and David J. Waxman
    Drug Metabolism and Disposition November 1999, 27 (11) 1309-1318;
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    Identification and Characterization of Efavirenz Metabolites by Liquid Chromatography/Mass Spectrometry and High Field NMR: Species Differences in the Metabolism of Efavirenz
    A. E. Mutlib, H. Chen, G. A. Nemeth, J. A. Markwalder, S. P. Seitz, L. S. Gan and D. D. Christ
    Drug Metabolism and Disposition November 1999, 27 (11) 1319-1333;
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    Cytochrome P-450-Mediated Metabolism of the Individual Enantiomers of the Antidepressant Agent Reboxetine in Human Liver Microsomes
    Larry C. Wienkers, Cecilia Allievi, Michael J. Hauer and Michael A. Wynalda
    Drug Metabolism and Disposition November 1999, 27 (11) 1334-1340;
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    Metabolites of [14C]-5-(2-Ethyl-2H-tetrazol-5-yl)-1-methyl-1,2,3,6-tetrahydropyridine in Mice, Rats, Dogs, and Humans
    Ellen Bech Christensen, Jan Bruun Andersen, Henrik Pedersen, Klaus Gjervig Jensen and Lars Dalgaard
    Drug Metabolism and Disposition November 1999, 27 (11) 1341-1349;
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    Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
    R. Scott Obach
    Drug Metabolism and Disposition November 1999, 27 (11) 1350-1359;
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    In Vitro and In Vivo Studies on the Metabolism of Tirofiban
    Stanley Vickers, Anthony D. Theoharides, Byron Arison, Suresh K. Balani, Dan Cui, Carol A. Duncan, Joan D. Ellis, Lynn M. Gorham, Stacey L. Polsky, Thomayant Prueksaritanont, Harri G. Ramjit, Donald E. Slaughter and Kamlesh P. Vyas
    Drug Metabolism and Disposition November 1999, 27 (11) 1360-1366;
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    Substance P Receptor Antagonist I: Conversion of Phosphoramidate Prodrug after i.v. Administration to Rats and Dogs
    Su-Er W. Huskey, Debra Luffer-Atlas, Brian J. Dean, Erin M. McGowan, William P. Feeney and Shuet-Hing Lee Chiu
    Drug Metabolism and Disposition November 1999, 27 (11) 1367-1373;

Erratum

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    Correction for vol. 27, p. 1187
    Drug Metabolism and Disposition November 1999, 27 (11) 1374;
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Drug Metabolism and Disposition: 27 (11)
Drug Metabolism and Disposition
Vol. 27, Issue 11
1 Nov 1999
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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