Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach

Article Information

vol. 27 no. 11 1350-1359

PubMed

10534321

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0090-9556

Online ISSN

1521-009X

History

Received April 9, 1999
Accepted July 30, 1999
Published online November 1, 1999.

The American Society for Pharmacology and Experimental Therapeutics

Author Information

R. Scott Obach

Drug Metabolism Department, Candidate Synthesis, Enhancement, and Evaluation, Central Research Division, Pfizer, Inc., Groton, Connecticut

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: October 1999 to April 2021

	Abstract	Full	Pdf
Oct 1999	51	104	144
Nov 1999	68	289	215
Dec 1999	10	70	45
Jan 2000	14	113	64
Feb 2000	13	146	94
Mar 2000	10	60	74
Apr 2000	4	13	35
May 2000	5	24	42
Jun 2000	6	29	27
Jul 2000	4	16	37
Aug 2000	3	14	47
Sep 2000	5	26	49
Oct 2000	6	17	33
Nov 2000	8	19	62
Dec 2000	2	14	29
Jan 2001	10	26	49
Feb 2001	7	26	54
Mar 2001	12	16	51
Apr 2001	5	31	84
May 2001	12	40	96
Jun 2001	2	27	58
Jul 2001	6	17	55
Aug 2001	1	37	52
Sep 2001	4	18	35
Oct 2001	4	23	58
Nov 2001	5	30	64
Dec 2001	5	25	45
Jan 2002	9	41	82
Feb 2002	8	40	87
Mar 2002	6	25	50
Apr 2002	4	35	59
May 2002	6	48	71
Jun 2002	3	45	92
Jul 2002	3	41	91
Aug 2002	5	43	61
Sep 2002	9	48	69
Oct 2002	20	49	78
Nov 2002	7	40	52
Dec 2002	5	37	66
Jan 2003	5	55	85
Feb 2003	6	45	110
Mar 2003	8	43	55
Apr 2003	6	44	94
May 2003	8	47	87
Jun 2003	4	45	78
Jul 2003	17	44	77
Aug 2003	7	67	63
Sep 2003	12	70	98
Oct 2003	14	80	89
Nov 2003	17	85	98
Dec 2003	7	58	54
Jan 2004	43	123	109
Feb 2004	12	81	92
Mar 2004	27	106	96
Apr 2004	16	87	86
May 2004	18	96	89
Jun 2004	30	119	76
Jul 2004	26	125	123
Aug 2004	30	103	89
Sep 2004	27	110	80
Oct 2004	44	169	97
Nov 2004	39	127	96
Dec 2004	28	107	58
Jan 2005	38	149	91
Feb 2005	51	186	120
Mar 2005	31	110	117
Apr 2005	27	101	108
May 2005	17	90	106
Jun 2005	27	86	87
Jul 2005	22	79	86
Aug 2005	18	100	103
Sep 2005	21	107	92
Oct 2005	27	102	99
Nov 2005	22	124	79
Dec 2005	20	72	81
Jan 2006	21	105	80
Feb 2006	23	100	63
Mar 2006	27	130	93
Apr 2006	32	71	72
May 2006	47	88	82
Jun 2006	54	92	84
Jul 2006	38	87	92
Aug 2006	47	74	83
Sep 2006	56	71	96
Oct 2006	39	65	87
Nov 2006	54	60	90
Dec 2006	46	40	69
Jan 2007	54	76	97
Feb 2007	65	74	92
Mar 2007	64	68	110
Apr 2007	73	64	105
May 2007	47	79	119
Jun 2007	42	67	85
Jul 2007	44	65	105
Aug 2007	31	42	74
Sep 2007	30	61	79
Oct 2007	44	56	72
Nov 2007	37	53	77
Dec 2007	16	26	42
Jan 2008	15	51	61
Feb 2008	21	52	69
Mar 2008	21	68	67
Apr 2008	28	86	80
May 2008	23	71	78
Jun 2008	28	83	103
Jul 2008	55	76	78
Aug 2008	54	80	78
Sep 2008	64	87	119
Oct 2008	105	103	106
Nov 2008	55	65	82
Dec 2008	37	56	86
Jan 2009	79	76	103
Feb 2009	49	66	88
Mar 2009	59	72	102
Apr 2009	46	62	96
May 2009	64	52	108
Jun 2009	65	61	92
Jul 2009	65	59	85
Aug 2009	58	67	79
Sep 2009	89	60	98
Oct 2009	87	63	114
Nov 2009	93	74	98
Dec 2009	141	63	95
Jan 2010	214	48	101
Feb 2010	181	49	126
Mar 2010	211	81	128
Apr 2010	142	124	87
May 2010	153	107	88
Jun 2010	141	98	96
Jul 2010	131	85	98
Aug 2010	125	122	96
Sep 2010	145	122	106
Oct 2010	166	125	81
Nov 2010	109	112	86
Dec 2010	108	69	66
Jan 2011	108	82	75
Feb 2011	94	84	67
Mar 2011	144	101	119
Apr 2011	129	61	99
May 2011	154	36	92
Jun 2011	83	41	73
Jul 2011	115	41	116
Aug 2011	126	60	119
Sep 2011	129	85	121
Oct 2011	131	76	148
Nov 2011	132	62	137
Dec 2011	117	59	119
Jan 2012	130	70	154
Feb 2012	137	75	150
Mar 2012	141	92	132
Apr 2012	152	110	115
May 2012	158	75	126
Jun 2012	125	87	112
Jul 2012	149	91	123
Aug 2012	149	88	107
Sep 2012	176	73	152
Oct 2012	209	80	218
Nov 2012	117	91	181
Dec 2012	113	90	190
Jan 2013	169	157	252
Feb 2013	155	140	236
Mar 2013	178	161	289
Apr 2013	142	122	204
May 2013	159	121	195
Jun 2013	127	78	177
Jul 2013	148	111	199
Aug 2013	162	95	164
Sep 2013	438	89	176
Oct 2013	759	96	193
Nov 2013	700	107	176
Dec 2013	137	83	155
Jan 2014	169	107	186
Feb 2014	149	106	176
Mar 2014	152	145	268
Apr 2014	181	128	188
May 2014	253	100	218
Jun 2014	133	73	139
Jul 2014	245	129	159
Aug 2014	136	154	154
Sep 2014	155	157	182
Oct 2014	173	154	150
Nov 2014	196	181	178
Dec 2014	160	142	122
Jan 2015	145	149	139
Feb 2015	189	112	182
Mar 2015	179	163	191
Apr 2015	146	131	199
May 2015	147	135	201
Jun 2015	160	161	210
Jul 2015	158	139	193
Aug 2015	114	139	149
Sep 2015	169	132	429
Oct 2015	248	139	156
Nov 2015	200	131	194
Dec 2015	155	104	144
Jan 2016	169	167	215
Feb 2016	138	146	219
Mar 2016	186	179	218
Apr 2016	183	164	242
May 2016	178	139	188
Jun 2016	147	126	207
Jul 2016	184	137	228
Aug 2016	164	151	168
Sep 2016	127	177	172
Oct 2016	76	307	158
Nov 2016	82	355	200
Dec 2016	48	295	202
Jan 2017	69	332	227
Feb 2017	67	200	191
Mar 2017	61	175	210
Apr 2017	49	1228	138
May 2017	72	265	178
Jun 2017	45	149	207
Jul 2017	58	152	117
Aug 2017	17	156	112
Sep 2017	39	226	129
Oct 2017	49	212	125
Nov 2017	45	259	133
Dec 2017	30	117	116
Jan 2018	48	189	150
Feb 2018	38	172	132
Mar 2018	40	277	217
Apr 2018	39	189	153
May 2018	45	180	162
Jun 2018	53	181	175
Jul 2018	38	131	148
Aug 2018	30	139	138
Sep 2018	30	133	109
Oct 2018	22	217	156
Nov 2018	44	281	133
Dec 2018	313	85	69
Jan 2019	312	63	49
Feb 2019	279	53	50
Mar 2019	248	39	40
Apr 2019	240	57	38
May 2019	196	62	46
Jun 2019	174	44	50
Jul 2019	187	58	48
Aug 2019	155	34	23
Sep 2019	178	50	49
Oct 2019	254	44	32
Nov 2019	212	58	46
Dec 2019	132	49	23
Jan 2020	183	56	41
Feb 2020	132	49	32
Mar 2020	246	66	45
Apr 2020	279	42	34
May 2020	412	46	54
Jun 2020	372	57	41
Jul 2020	269	41	37
Aug 2020	190	26	23
Sep 2020	288	72	42
Oct 2020	187	136	43
Nov 2020	257	39	28
Dec 2020	187	47	29
Jan 2021	232	145	41
Feb 2021	261	159	52
Mar 2021	255	72	38
Apr 2021	110	45	28