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Research ArticleArticle

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach
Drug Metabolism and Disposition November 1999, 27 (11) 1350-1359;

Article Information

vol. 27 no. 11 1350-1359
PubMed 
10534321
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 9, 1999
  • Accepted July 30, 1999
  • Published online November 1, 1999.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. R. Scott Obach
  1. Drug Metabolism Department, Candidate Synthesis, Enhancement, and Evaluation, Central Research Division, Pfizer, Inc., Groton, Connecticut
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    Research ArticleArticle

    Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

    R. Scott Obach
    Drug Metabolism and Disposition November 1, 1999, 27 (11) 1350-1359;
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