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Research ArticleArticle

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach
Drug Metabolism and Disposition November 1999, 27 (11) 1350-1359;
R. Scott Obach
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Article Information

vol. 27 no. 11 1350-1359
PubMed 
10534321

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 9, 1999
  • Accepted July 30, 1999
  • Published online November 1, 1999.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. R. Scott Obach
  1. Drug Metabolism Department, Candidate Synthesis, Enhancement, and Evaluation, Central Research Division, Pfizer, Inc., Groton, Connecticut
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    Drug Metabolism and Disposition: 27 (11)
    Drug Metabolism and Disposition
    Vol. 27, Issue 11
    1 Nov 1999
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    Research ArticleArticle

    Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

    R. Scott Obach
    Drug Metabolism and Disposition November 1, 1999, 27 (11) 1350-1359;

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    Research ArticleArticle

    Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

    R. Scott Obach
    Drug Metabolism and Disposition November 1, 1999, 27 (11) 1350-1359;
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