Advertisement
Research ArticleArticle

Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach
Drug Metabolism and Disposition November 1999, 27 (11) 1350-1359;

Article Information

vol. 27 no. 11 1350-1359
PubMed 
10534321
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 9, 1999
  • Accepted July 30, 1999
  • Published online November 1, 1999.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. R. Scott Obach
  1. Drug Metabolism Department, Candidate Synthesis, Enhancement, and Evaluation, Central Research Division, Pfizer, Inc., Groton, Connecticut
    View Full Text

    Statistics from Altmetric.com

    Article usage

    Article usage: August 2017 to September 2023

    AbstractFullPdf
    Aug 201717156112
    Sep 201737213120
    Oct 201749212125
    Nov 201745259133
    Dec 201730117116
    Jan 201848189150
    Feb 201838172132
    Mar 201840277217
    Apr 201839189153
    May 201845180162
    Jun 201853181175
    Jul 201838131148
    Aug 201830139138
    Sep 201830133109
    Oct 201822217156
    Nov 201844281133
    Dec 20183138569
    Jan 20193126349
    Feb 20192795350
    Mar 20192483940
    Apr 20192405738
    May 20191966246
    Jun 20191744450
    Jul 20191875848
    Aug 20191553423
    Oct 20192544432
    Nov 20192125846
    Dec 20191324923
    Jan 20201835641
    Feb 20201324932
    Mar 20202466645
    May 20204124654
    Jun 20203725741
    Jul 20202694137
    Aug 20201892421
    Sep 20202887242
    Oct 202018713643
    Nov 20202573928
    Dec 20201874729
    Jan 202123214541
    Feb 202126115952
    Mar 20212557238
    Apr 20212126338
    May 20212097826
    Jun 20213119342
    Jul 20213154934
    Aug 202120111122
    Sep 20212736822
    Oct 20212294626
    Nov 20212785938
    Dec 20214084824
    Jan 20222414931
    Feb 20221673618
    Mar 20223105235
    Apr 20222593234
    May 20222794144
    Jun 20222643131
    Jul 20222044526
    Aug 20222017135
    Sep 20223536327
    Oct 202229415747
    Nov 20222824431
    Dec 20224393620
    Jan 20233488328
    Feb 20233705229
    Mar 20234615637
    Apr 20233405521
    May 202334410312
    Jun 20233075628
    Jul 20233687024
    Aug 202346112534
    Sep 20234445432

    Back to top

    In this issue

    Download PDF
    Article Alerts
    Email Article
    Citation Tools

    Research ArticleArticle

    Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

    R. Scott Obach
    Drug Metabolism and Disposition November 1, 1999, 27 (11) 1350-1359;
    Reddit logo Twitter logo Facebook logo Mendeley logo

    Jump to section

    Advertisement