Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes

R. Scott Obach

Article Information

vol. 27 no. 11 1350-1359

PubMed

10534321

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0090-9556

Online ISSN

1521-009X

History

Received April 9, 1999
Accepted July 30, 1999
Published online November 1, 1999.

The American Society for Pharmacology and Experimental Therapeutics

Author Information

R. Scott Obach

Drug Metabolism Department, Candidate Synthesis, Enhancement, and Evaluation, Central Research Division, Pfizer, Inc., Groton, Connecticut

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	Abstract	Full	Pdf
Oct 1999	51	104	144
Nov 1999	68	289	215
Dec 1999	10	70	45
Jan 2000	14	113	64
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Oct 2011	131	76	148
Nov 2011	132	62	137
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Aug 2012	149	88	107
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Jul 2013	148	111	199
Aug 2013	162	95	164
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Oct 2013	759	96	193
Nov 2013	700	107	176
Dec 2013	137	83	155
Jan 2014	169	107	186
Feb 2014	149	106	176
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Apr 2014	181	128	188
May 2014	253	100	218
Jun 2014	133	73	139
Jul 2014	245	129	159
Aug 2014	136	154	154
Sep 2014	155	157	182
Oct 2014	173	154	150
Nov 2014	196	181	178
Dec 2014	160	142	122
Jan 2015	145	149	139
Feb 2015	189	112	182
Mar 2015	179	163	191
Apr 2015	146	131	199
May 2015	147	135	201
Jun 2015	160	161	210
Jul 2015	158	139	193
Aug 2015	114	139	149
Sep 2015	169	132	429
Oct 2015	248	139	156
Nov 2015	200	131	194
Dec 2015	155	104	144
Jan 2016	169	167	215
Feb 2016	138	146	219
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Apr 2016	183	164	242
May 2016	178	139	188
Jun 2016	147	126	207
Jul 2016	184	137	228
Aug 2016	164	151	168
Sep 2016	127	177	172
Oct 2016	76	307	158
Nov 2016	82	355	200
Dec 2016	48	295	202
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Feb 2017	67	200	191
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Apr 2017	49	1228	138
May 2017	72	265	178
Jun 2017	45	149	207
Jul 2017	58	152	117
Aug 2017	17	156	112
Sep 2017	39	226	129
Oct 2017	49	212	125
Nov 2017	45	259	133
Dec 2017	30	117	116
Jan 2018	48	189	150
Feb 2018	38	172	132
Mar 2018	40	277	217
Apr 2018	39	189	153
May 2018	45	180	162
Jun 2018	53	181	175
Jul 2018	38	131	148
Aug 2018	30	139	138
Sep 2018	30	133	109
Oct 2018	22	217	156
Nov 2018	44	281	133
Dec 2018	313	85	69
Jan 2019	312	63	49
Feb 2019	279	53	50
Mar 2019	248	39	40
Apr 2019	240	57	38
May 2019	196	62	46
Jun 2019	174	44	50
Jul 2019	187	58	48
Aug 2019	155	34	23
Sep 2019	178	50	49
Oct 2019	254	44	32
Nov 2019	212	58	46
Dec 2019	132	49	23
Jan 2020	183	56	41
Feb 2020	132	49	32
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Apr 2020	279	42	34
May 2020	412	46	54
Jun 2020	372	57	41
Jul 2020	269	41	37
Aug 2020	190	26	23
Sep 2020	288	72	42
Oct 2020	187	136	43
Nov 2020	257	39	28
Dec 2020	187	47	29
Jan 2021	232	145	41
Feb 2021	261	159	52
Mar 2021	255	72	38
Apr 2021	212	63	38
May 2021	209	78	26
Jun 2021	311	93	42
Jul 2021	315	49	34
Aug 2021	201	111	22
Sep 2021	273	68	22
Oct 2021	229	46	26
Nov 2021	278	59	38
Dec 2021	408	48	24
Jan 2022	241	49	31
Feb 2022	167	36	18
Mar 2022	288	51	35
Apr 2022	254	31	34
May 2022	142	19	29