Table of Contents

Articles

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  Inhibitory Anti-CYP3A4 Peptide Antibody: Mapping of Inhibitory Epitope and Specificity Toward Other CYP3A Isoforms

  Regina W. Wang, Deborah J. Newton, Nini Y. Liu, Magang Shou, Tom Rushmore and Anthony Y. H. Lu

  Drug Metabolism and Disposition February 1999, 27 (2) 167-172;
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  Comparison of Cytochrome P-450-Dependent Metabolism and Drug Interactions of the 3-Hydroxy-3-methylglutaryl-CoA Reductase Inhibitors Lovastatin and Pravastatin in the Liver

  Wolfgang Jacobsen, Gabriele Kirchner, Katrin Hallensleben, Laviero Mancinelli, Michael Deters, Ingelore Hackbarth, Leslie Z. Benet, Karl-Fr. Sewing and Uwe Christians

  Drug Metabolism and Disposition February 1999, 27 (2) 173-179;
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  Inhibition of Cytochrome P-450 3A (CYP3A) in Human Intestinal and Liver Microsomes: Comparison of K _i Values and Impact of CYP3A5 Expression

  Megan A. Gibbs, Kenneth E. Thummel, Danny D. Shen and Kent L. Kunze

  Drug Metabolism and Disposition February 1999, 27 (2) 180-187;
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  Developmental Changes in the Catalytic Activity and Expression of CYP2D Isoforms in the Rat Liver

  Toshio Chow, Susumu Imaoka, Toyoko Hiroi and Yoshihiko Funae

  Drug Metabolism and Disposition February 1999, 27 (2) 188-192;
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  Cytochrome P-450 mRNAs Are Modulated by Dehydroepiandrosterone, Nafenopin, and Triiodothyronine

  David W. Singleton, Xiang-Dong Lei, Stephanie J. Webb, Russell A. Prough and Thomas E. Geoghegan

  Drug Metabolism and Disposition February 1999, 27 (2) 193-200;
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  A Controlled Pharmacokinetic Evaluation of Tizanidine and Baclofen at Steady State

  M. Kent Shellenberger, Lesley Groves, Jaymin Shah and Gary D. Novack

  Drug Metabolism and Disposition February 1999, 27 (2) 201-204;
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  In Vivo Metabolism of a New Anticancer Agent, 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(β-d-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506) in Rats and Dogs: Pharmacokinetics, Isolation, Identification, and Quantification of Metabolites

  N. Takenaga, M. Ishii, S. Nakajima, T. Hasegawa, R. Iwasa, H. Ishizaki and T. Kamei

  Drug Metabolism and Disposition February 1999, 27 (2) 205-212;
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  In Vitro Metabolism of a New Anticancer Agent, 6-N-formylamino-12,13-dihydro-1,11-dihydroxy-13-(β-d-glucopyranosil)5H-indolo [2,3-a]pyrrolo [3,4-c]carbazole-5,7(6H)-dione (NB-506), in Mice, Rats, Dogs, and Humans

  N. Takenaga, T. Hasegawa, M. Ishii, H. Ishizaki, S. Hata and T. Kamei

  Drug Metabolism and Disposition February 1999, 27 (2) 213-220;
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  Pharmacokinetics of a Chemoprotective Agent, 2-(Allylthio)pyrazine, after Intravenous and Oral Administration to Rats: Hepatic and Gastric First-Pass Effects

  Kye S. Han and Myung G. Lee

  Drug Metabolism and Disposition February 1999, 27 (2) 221-226;
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  High In Situ Rat Intestinal Permeability of Artemisinin Unaffected by Multiple Dosing and with No Evidence of P-glycoprotein Involvement

  Ulrika S. H. Svensson, Rikard Sandström, Örjan Carlborg, Hans Lennernäs and Michael Ashton

  Drug Metabolism and Disposition February 1999, 27 (2) 227-232;
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  Inactivation of Cytochrome P-450 (CYP2E1) and Carboxylesterase (Hydrolase A) Enzymes by Vinyl Carbamate in Murine Pulmonary Microsomes

  Raymond P. Lee and Poh-Gek Forkert

  Drug Metabolism and Disposition February 1999, 27 (2) 233-239;
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  In Vivo Metabolism of the Antitumor Imidazoacridinone C1311 in the Mouse and In Vitro Comparison with Humans

  C. R. Calabrese, P. M. Loadman, L. S. E. Lim, M. C. Bibby, J. A. Double, J. E. Brown and J. H. Lamb

  Drug Metabolism and Disposition February 1999, 27 (2) 240-245;
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  Effect of Methanol, Ethanol, Dimethyl Sulfoxide, and Acetonitrile on In Vitro Activities of cDNA-Expressed Human Cytochromes P-450

  William F. Busby, Joseph M. Ackermann and Charles L. Crespi

  Drug Metabolism and Disposition February 1999, 27 (2) 246-249;
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  In Vitro Evaluation of Potential Drug Interactions With Levetiracetam, A New Antiepileptic Agent

  Jean-Marie Nicolas, Philippe Collart, Brigitte Gerin, Gary Mather, William Trager, Rene Levy and Jose Roba

  Drug Metabolism and Disposition February 1999, 27 (2) 250-254;
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  Metabolism of 3,5,5-Trimethylhexanoyl-Ferrocene by Rat Liver: Release of Iron from 3,5,5-Trimethylhexanoyl-Ferrocene by a Microsomal, Phenobarbital-Inducible Cytochrome P-450

  Edward E. Cable and Harriet C. Isom

  Drug Metabolism and Disposition February 1999, 27 (2) 255-260;
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  Developmental Expression of N-Acetyltransferases in C57BI/6 Mice

  M. Kimberly Mitchell, Bernard W. Futscher and Charlene A. McQueen

  Drug Metabolism and Disposition February 1999, 27 (2) 261-264;
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  Relative Plasma Levels of the Cardioprotective Drug Dexrazoxane and Its Two Active Ring-Opened Metabolites in the Rat

  Brian B. Hasinoff and Ronald G. Aoyama

  Drug Metabolism and Disposition February 1999, 27 (2) 265-268;
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  Characterization of Eprinomectin N-Deacetylase in Rats

  Zhaopie Zeng and Nicholas W. Andrew

  Drug Metabolism and Disposition February 1999, 27 (2) 269-273;
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  Development of an AntiPeptide Antibody That Binds to the C-Terminal Region of Human CYP1B1

  Yong Ming Tang, Gen-Fu Chen, Patricia A. Thompson, Dong-Xin Lin, Nicholas P. Lang and Fred F. Kadlubar

  Drug Metabolism and Disposition February 1999, 27 (2) 274-280;
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  Induction of Cytochrome P-450 Enzymes after Repeated Exposure to 4-Vinylcyclohexene in B6C3F₁ Mice

  Julie K. Doerr-Stevens, Juping Liu, Gregory J. Stevens, James C. Kraner, Susan M. Fontaine, James R. Halpert and I. Glenn Sipes

  Drug Metabolism and Disposition February 1999, 27 (2) 281-287;
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  Role of Cytochrome P-4502C9 in Irbesartan Oxidation by Human Liver Microsomes

  Martine Bourrié, Viviane Meunier, Yves Berger and Gérard Fabre

  Drug Metabolism and Disposition February 1999, 27 (2) 288-296;
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  Role of the Liver and Gut in Systemic Diphenhydramine Clearance in Adult Nonpregnant Sheep

  Sanjeev Kumar, K. Wayne Riggs and Dan W. Rurak

  Drug Metabolism and Disposition February 1999, 27 (2) 297-302;
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  Cytochrome P-450 Isoforms Involved in Carboxylic Acid Ester Cleavage of Hantzsch Pyridine Ester of Pranidipine

  Shoji Kudo, Hiroshi Okumura, Gohachiro Miyamoto and Takashi Ishizaki

  Drug Metabolism and Disposition February 1999, 27 (2) 303-308;
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  Identification of (−)-Epicatechin Metabolites and Their Metabolic Fate in the Rat

  Kazuo Okushio, Masayuki Suzuki, Natsuki Matsumoto, Fumio Nanjo and Yukihiko Hara

  Drug Metabolism and Disposition February 1999, 27 (2) 309-316;