Cover Caption

About the cover: Theoretical mechanisms for the decreased bioavailability of artemisinin after multiple administration (ART, artemisinin) in rats. Inset A shows the increased efflux of artemisinin into the lumen due to induction of carrier-mediated transport proteins, decreased passive diffusion, and increased metabolism associated with induction. Inset B shows decreased protein binding. Inset C diagrams increased hepatocellular capacity due to induction of enzymes via increased transcription (1), mRNA stabilization (2), increased translation (3), or protein stabilization/activation (4). See the article by Svensson et al. on page 227 in this issue.