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Meeting ReportSymposium Article

Molecular and Physical Mechanisms of First-Pass Extraction

Stephen D. Hall, Kenneth E. Thummel, Paul B. Watkins, Kenneth S. Lown, Leslie Z. Benet, Mary F. Paine, Robert R. Mayo, D. Kim Turgeon, David G. Bailey, Robert J. Fontana and Steven A. Wrighton
Drug Metabolism and Disposition February 1999, 27 (2) 161-166;
Stephen D. Hall
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Kenneth E. Thummel
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Paul B. Watkins
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Kenneth S. Lown
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Leslie Z. Benet
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Mary F. Paine
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Robert R. Mayo
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D. Kim Turgeon
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David G. Bailey
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Robert J. Fontana
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Article Information

vol. 27 no. 2 161-166
PubMed 
9929497

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 19, 1998
  • Accepted September 1, 1998
  • Published online February 1, 1999.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stephen D. Hall5,
  2. Kenneth E. Thummel1,
  3. Paul B. Watkins1,2,
  4. Kenneth S. Lown2,
  5. Leslie Z. Benet3,
  6. Mary F. Paine1,
  7. Robert R. Mayo2,
  8. D. Kim Turgeon2,
  9. David G. Bailey4,
  10. Robert J. Fontana2 and
  11. Steven A. Wrighton6
  1. 1Department of Pharmaceutics, University of Washington, Seattle, Washington (K.E.T., M.F.P.); 2Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan (P.B.W., K.S.L., R.J.F., R.R.M., D.K.M.); 3Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California (L.Z.B.); 4Department of Medicine, London Health Sciences Centre, Ontario, Canada (D.G.B.); 5Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana (S.D.H.); 6and Department of Drug Metabolism and Disposition, Lilly Research Laboratories, Indianapolis, Indiana (S.A.W.)
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    Drug Metabolism and Disposition: 27 (2)
    Drug Metabolism and Disposition
    Vol. 27, Issue 2
    1 Feb 1999
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    Meeting ReportSymposium Article

    Molecular and Physical Mechanisms of First-Pass Extraction

    Stephen D. Hall, Kenneth E. Thummel, Paul B. Watkins, Kenneth S. Lown, Leslie Z. Benet, Mary F. Paine, Robert R. Mayo, D. Kim Turgeon, David G. Bailey, Robert J. Fontana and Steven A. Wrighton
    Drug Metabolism and Disposition February 1, 1999, 27 (2) 161-166;

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    Meeting ReportSymposium Article

    Molecular and Physical Mechanisms of First-Pass Extraction

    Stephen D. Hall, Kenneth E. Thummel, Paul B. Watkins, Kenneth S. Lown, Leslie Z. Benet, Mary F. Paine, Robert R. Mayo, D. Kim Turgeon, David G. Bailey, Robert J. Fontana and Steven A. Wrighton
    Drug Metabolism and Disposition February 1, 1999, 27 (2) 161-166;
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    • Article
      • Abstract
      • Role of Enterocyte CYP3A in the First-Pass Extraction of Midazolam (K.E.T., M.F.P.)
      • Assessing the Role of Intestinal CYP3A4 in Limiting Oral Delivery of Drugs: New Approaches (P.B.W., D.G.B., K.S.L., R.J.F.)
      • The Emerging Role of Intestinal P-Glycoprotein (MDR1) in Oral Drug Availability (K.S.L., R.R.M., D.K.T., P.B.W.)
      • Overlapping Substrate Specificities of CYP3A4 and P-Glycoprotein: Implications in Drug Delivery (L.Z.B.)
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