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PubMed
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History
- Received August 19, 1998
- Accepted September 1, 1998
- Published online February 1, 1999.
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The American Society for Pharmacology and Experimental Therapeutics
Author Information
- Stephen D. Hall5,
- Kenneth E. Thummel1,
- Paul B. Watkins1,2,
- Kenneth S. Lown2,
- Leslie Z. Benet3,
- Mary F. Paine1,
- Robert R. Mayo2,
- D. Kim Turgeon2,
- David G. Bailey4,
- Robert J. Fontana2 and
- Steven A. Wrighton6
- 1Department of Pharmaceutics, University of Washington, Seattle, Washington (K.E.T., M.F.P.); 2Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan (P.B.W., K.S.L., R.J.F., R.R.M., D.K.M.); 3Department of Biopharmaceutical Sciences, University of California San Francisco, San Francisco, California (L.Z.B.); 4Department of Medicine, London Health Sciences Centre, Ontario, Canada (D.G.B.); 5Department of Medicine, Indiana University School of Medicine, Indianapolis, Indiana (S.D.H.); 6and Department of Drug Metabolism and Disposition, Lilly Research Laboratories, Indianapolis, Indiana (S.A.W.)
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Molecular and Physical Mechanisms of First-Pass Extraction
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- Article
- Abstract
- Role of Enterocyte CYP3A in the First-Pass Extraction of Midazolam (K.E.T., M.F.P.)
- Assessing the Role of Intestinal CYP3A4 in Limiting Oral Delivery of Drugs: New Approaches (P.B.W., D.G.B., K.S.L., R.J.F.)
- The Emerging Role of Intestinal P-Glycoprotein (MDR1) in Oral Drug Availability (K.S.L., R.R.M., D.K.T., P.B.W.)
- Overlapping Substrate Specificities of CYP3A4 and P-Glycoprotein: Implications in Drug Delivery (L.Z.B.)
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