Drug Metabolism and Disposition: 27 (3)

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About the cover: Western blots of human small intestinal microsomes (HG) showing the presence of CYP1A1 protein in only three samples (A) or CYP3A4 protein in all samples (B). See the article by Paine et al. on page 360 in this issue.

In this issue

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

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