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Research ArticleArticle

Quantitative Prediction of Metabolic Inhibition of Midazolam by Itraconazole and Ketoconazole in Rats: Implication of Concentrative Uptake of Inhibitors into Liver

Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Yasufumi Sawada and Tatsuji Iga
Drug Metabolism and Disposition March 1999, 27 (3) 395-402;
Katsuhiro Yamano
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Koujirou Yamamoto
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Hajime Kotaki
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Yasufumi Sawada
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Tatsuji Iga
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Article Information

vol. 27 no. 3 395-402
PubMed 
10064572

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received June 15, 1998
  • Accepted December 7, 1998
  • Published online March 1, 1999.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Katsuhiro Yamano1,3,
  2. Koujirou Yamamoto2,
  3. Hajime Kotaki3,
  4. Yasufumi Sawada4 and
  5. Tatsuji Iga3
  1. 1Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Kashima, Yodogawa-ku, Osaka, Japan (Ka.Y.); 2Department of Clinical Pharmacology School of Medicine, Gunma University, Showa machi, Maebashi, Japan (Ko.Y.); 3Department of Pharmacy, University of Tokyo Hospital, Faculty of Medicine, University of Tokyo, Hongo, Bunkyo-ku, Tokyo, Japan (Ka.Y., H.K., T.I.); and 4Faculty of Pharmaceutical Sciences, Kyushu University, Maidashi, Higashi-ku, Fukuoka, Japan (Y.S.)
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    Drug Metabolism and Disposition: 27 (3)
    Drug Metabolism and Disposition
    Vol. 27, Issue 3
    1 Mar 1999
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    Research ArticleArticle

    Quantitative Prediction of Metabolic Inhibition of Midazolam by Itraconazole and Ketoconazole in Rats: Implication of Concentrative Uptake of Inhibitors into Liver

    Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Yasufumi Sawada and Tatsuji Iga
    Drug Metabolism and Disposition March 1, 1999, 27 (3) 395-402;

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    Research ArticleArticle

    Quantitative Prediction of Metabolic Inhibition of Midazolam by Itraconazole and Ketoconazole in Rats: Implication of Concentrative Uptake of Inhibitors into Liver

    Katsuhiro Yamano, Koujirou Yamamoto, Hajime Kotaki, Yasufumi Sawada and Tatsuji Iga
    Drug Metabolism and Disposition March 1, 1999, 27 (3) 395-402;
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