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Drug Metabolism & Disposition

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Table of Contents

April 01, 1999; Volume 27,Issue 4

Short Communications

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    In Vivo Disposition of 3-Nitro-l-Tyrosine in Rats: Implications on Tracking Systemic Peroxynitrite Exposure
    Mohammad A. Tabrizi-Fard, Tristan S. Maurer and Ho-Leung Fung
    Drug Metabolism and Disposition April 1999, 27 (4) 429-431;
  • You have access
    Pharmacokinetics of Aminolevulinic Acid after Oral and Intravenous Administration in Dogs
    James Meyer, Marvin C. Meyer and Allyn L. Golub
    Drug Metabolism and Disposition April 1999, 27 (4) 432-435;
  • You have access
    Improved Reliability of the Rapid Microtiter Plate Assay Using Recombinant Enzyme in Predicting CYP2D6 Inhibition in Human Liver Microsomes
    Leonard V. Favreau, Jairam R. Palamanda, Chin-chung Lin and Amin A. Nomeir
    Drug Metabolism and Disposition April 1999, 27 (4) 436-439;
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    Possible Involvement of P-Glycoprotein in Biliary Excretion of CPT-11 in Rats
    Xiao-Yan Chu, Yukio Kato and Yuichi Sugiyama
    Drug Metabolism and Disposition April 1999, 27 (4) 440-441;

Articles

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    Bioavailability and Metabolism of Hydroquinone after Intratracheal Instillation in Male Rats
    Peter J. Deisinger and J. Caroline English
    Drug Metabolism and Disposition April 1999, 27 (4) 442-448;
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    Effect of Cyclosporine A on Cytochrome P-450-Mediated Drug Metabolism in the Partially Hepatectomized Rat
    Sébastien J. Provencher, Christian Demers, Marie-Claude Bastien, Jean-Pierre Villeneuve and Marielle Gascon-Barré
    Drug Metabolism and Disposition April 1999, 27 (4) 449-455;
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    Characterization of Metabolites of Astaxanthin in Primary Cultures of Rat Hepatocytes
    Erich Wolz, Hans Liechti, Brigitte Notter, Gottfried Oesterhelt and Andreas Kistler
    Drug Metabolism and Disposition April 1999, 27 (4) 456-462;
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    Comparative Formation, Distribution, and Elimination Kinetics of Diphenylmethoxyacetic Acid (a Diphenhydramine Metabolite) in Maternal and Fetal Sheep
    Sanjeev Kumar, K. Wayne Riggs and Dan W. Rurak
    Drug Metabolism and Disposition April 1999, 27 (4) 463-470;
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    Metabolism and Disposition of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (NNK) in Rhesus Monkeys
    Michael Meger, Elmar Richter, Wolfgang Zwickenpflug, Christiana Oehlmann, Maureen B. Hargaden, Yousif I. A-Rahim and Elliot S. Vesell
    Drug Metabolism and Disposition April 1999, 27 (4) 471-478;
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    Intestinal Metabolism and Transport of 5-Aminosalicylate
    S. Y. Zhou, D. Fleisher, L. H. Pao, C. Li, B. Winward and E. M. Zimmermann
    Drug Metabolism and Disposition April 1999, 27 (4) 479-485;
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    Biotransformation of Curcumin Through Reduction and Glucuronidation in Mice
    Min-Hsiung Pan, Tsang-Miao Huang and Jen-Kun Lin
    Drug Metabolism and Disposition April 1999, 27 (4) 486-494;
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    Effect of Its Demethylated Metabolite on the Pharmacokinetics of Unchanged Tak-603, A New Antirheumatic Agent, in Rats
    Yoshihiko Tagawa, Kiyoshi Miwa, Ryoichi Tsukuda, Yoshinobu Yoshimura, Shigeharu Tanayama and Yusuke Tanigawara
    Drug Metabolism and Disposition April 1999, 27 (4) 495-501;
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    Reaction of Organic Nitrate Esters andS-Nitrosothiols With Reduced Flavins: A Possible Mechanism of Bioactivation
    Patrick S.-Y. Wong and Jon M. Fukuto
    Drug Metabolism and Disposition April 1999, 27 (4) 502-509;
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    Disposition and Metabolism of 2-(2"(1",3"-Dioxolan-2-Yl)-2-Methyl-4-(2′-Oxopyrrolidin-1-Yl)-6-Nitro-2h-1-Benzopyran (skp-450) in Rats
    Minsun Baek, Hak Soon Chung, Yunje Kim and Dong-Hyun Kim
    Drug Metabolism and Disposition April 1999, 27 (4) 510-516;
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    Monospecific Antipeptide Antibody to Cytochrome P-450 2B6
    David M. Stresser and David Kupfer
    Drug Metabolism and Disposition April 1999, 27 (4) 517-525;
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    Kinetics of Drug Metabolism in Rat Liver Slices: IV. Comparison of Ethoxycoumarin Clearance by Liver Slices, Isolated Hepatocytes, and Hepatic Microsomes from Rats Pretreated with Known Modifiers of Cytochrome P-450 Activity
    David J. Carlile, Nancy Hakooz and J. Brian Houston
    Drug Metabolism and Disposition April 1999, 27 (4) 526-532;
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    Role of CYP2B6 and CYP3A4 in the In VitroN-Dechloroethylation of (R)- and (S)-Ifosfamide in Human Liver Microsomes
    Camille P. Granvil, Ajay Madan, Mahmoud Sharkawi, Andrew Parkinson and Irving W. Wainer
    Drug Metabolism and Disposition April 1999, 27 (4) 533-541;
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    Cellular Distribution of Cytochromes P-450 in the Rat Kidney
    Brian S. Cummings, Richard C. Zangar, Raymond F. Novak and Lawrence H. Lash
    Drug Metabolism and Disposition April 1999, 27 (4) 542-548;
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    Tightly Regulated and Inducible Expression of Rabbit Cyp2e1 Using A Tetracycline-Controlled Expression System
    Jian-Ya Huan and Dennis R. Koop
    Drug Metabolism and Disposition April 1999, 27 (4) 549-554;
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Drug Metabolism and Disposition: 27 (4)
Drug Metabolism and Disposition
Vol. 27, Issue 4
1 Apr 1999
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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