Table of Contents

Articles

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  The Disposition of ¹⁴C-Labeled Tacrolimus after Intravenous and Oral Administration in Healthy Human Subjects

  A. Möller, K. Iwasaki, A. Kawamura, Y. Teramura, T. Shiraga, T. Hata, A. Schäfer and N. A. Undre

  Drug Metabolism and Disposition June 1999, 27 (6) 633-636;
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  Correlation of Biliary Excretion in Sandwich-Cultured Rat Hepatocytes and In Vivo in Rats

  Xingrong Liu, Jack P. Chism, Edward L. LeCluyse, Kenneth R. Brouwer and Kim L.R. Brouwer

  Drug Metabolism and Disposition June 1999, 27 (6) 637-644;
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  Comparative Pharmacokinetics and Tissue Distribution of the d-Enantiomers of Para-Substituted Methylphenidate Analogs

  Dung L. Thai, Linda N. Yurasits, George R. Rudolph and James M. Perel

  Drug Metabolism and Disposition June 1999, 27 (6) 645-650;
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  Dihydropyrimidine Dehydrogenase Activity and Fluorouracil Pharmacokinetics with Liver Damage Induced by Bile Duct Ligation in Rats

  Tomonori Tateishi, Minoru Watanabe, Hironori Nakura, Masami Tanaka, Toshio Kumai, Shigeko Fujimoto Sakata, Nanaya Tamaki, Kenichiro Ogura, Takahito Nishiyama, Tadashi Watabe and Shinichi Kobayashi

  Drug Metabolism and Disposition June 1999, 27 (6) 651-654;
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  Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles

  Partha Roy, Li J. Yu, Charles L. Crespi and David J. Waxman

  Drug Metabolism and Disposition June 1999, 27 (6) 655-666;
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  Molecular Basis for Hepatic Detoxifying Enzyme Induction by 2-(Allylthio)pyrazine in Rats in Comparison with Oltipraz: Effects on Prooxidant Production and DNA Degradation

  Sang Geon Kim, Min Kyung Cho, Sung Hee Choi, Hye Jung Kim, Mi Kyong Kwak and Nak Doo Kim

  Drug Metabolism and Disposition June 1999, 27 (6) 667-673;
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  Comparative Disposition of the NephrotoxicantN-(3,5-Dichlorophenyl)Succinimide and the Non-Nephrotoxicant N-(3,5-Difluorophenyl)Succinimide in Fischer 344 Rats

  Caroline M. Henesey, Ginny L. Kellner-Weibel, Joan B. Tarloff and Peter J. Harvison

  Drug Metabolism and Disposition June 1999, 27 (6) 674-680;
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  Cytochrome P-450 3A and 2D6 Catalyze OrthoHydroxylation of 4-Hydroxytamoxifen and 3-Hydroxytamoxifen (Droloxifene) Yielding Tamoxifen Catechol: Involvement of Catechols in Covalent Binding to Hepatic Proteins

  Shangara S. Dehal and David Kupfer

  Drug Metabolism and Disposition June 1999, 27 (6) 681-688;
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  Effect of PSC 833, a P-Glycoprotein Modulator, on the Disposition of Vincristine and Digoxin in Rats

  SaeHeum Song, Hiroshi Suzuki, Ryosei Kawai and Yuichi Sugiyama

  Drug Metabolism and Disposition June 1999, 27 (6) 689-694;
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  Effect of Leptin on Cytochrome P-450, Conjugation, and Antioxidant Enzymes in the ob/ob Mouse

  Angela M. Watson, Samuel M. Poloyac, Georgette Howard and Robert A. Blouin

  Drug Metabolism and Disposition June 1999, 27 (6) 695-700;
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  Cardiovascular Effect and Simultaneous Pharmacokinetic and Pharmacodynamic Modeling of Pimobendan in Healthy Normal Subjects

  Kai-Min Chu, Oliver Yoa-Pu Hu and Shyh-Ming Shieh

  Drug Metabolism and Disposition June 1999, 27 (6) 701-709;
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  Pharmacokinetic Changes of a New Carbapenem, DA-1131, after Intravenous Administration to Spontaneously Hypertensive Rats and Deoxycorticosterone Acetate-Salt-Induced Hypertensive Rats

  So H. Kim, Won B. Kim and Myung G. Lee

  Drug Metabolism and Disposition June 1999, 27 (6) 710-716;
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  Lack of Single-Dose Disulfiram Effects on Cytochrome P-450 2C9, 2C19, 2D6, and 3A4 Activities: Evidence for Specificity Toward P-450 2E1

  Evan D. Kharasch, Douglas C. Hankins, Carole Jubert, Kenneth E. Thummel and Julie K. Taraday

  Drug Metabolism and Disposition June 1999, 27 (6) 717-723;
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  Panipenem, A Carbapenem Antibiotic, Enhances the Glucuronidation of Intravenously Administered Valproic Acid in Rats

  Naotoshi Yamamura, Kaoru Imura, Hideo Naganuma and Kenji Nishimura

  Drug Metabolism and Disposition June 1999, 27 (6) 724-730;
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  Deposition of [³H]Cocaine, [³H]Nicotine, and [³H]Flunitrazepam in Mouse Hair Melanosomes after Systemic Administration

  Peter R. Stout and James A. Ruth

  Drug Metabolism and Disposition June 1999, 27 (6) 731-735;
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  Presystemic Metabolism of Albendazole: Experimental Evidence of an Efflux Process of Albendazole Sulfoxide to Intestinal Lumen

  P. A. Redondo, A. I. Álvarez, J. L. Garcia, O. M. Larrodé, G. Merino and J. G. Prieto

  Drug Metabolism and Disposition June 1999, 27 (6) 736-740;
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  Mechanism-Based Inactivation of Rat Liver Cytochrome P-450 2B1 by 2-Methoxy-5-nitrobenzyl Bromide

  Arthur P. Armstrong and Paul F. Hollenberg

  Drug Metabolism and Disposition June 1999, 27 (6) 741-745;
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  The Multiple Indicator-Dilution Method for the Study of Enzyme Heterogeneity in Liver: Theoretical Basis

  Andreas J. Schwab and K. Sandy Pang

  Drug Metabolism and Disposition June 1999, 27 (6) 746-755;
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  Estimation of K _i in a Competitive Enzyme-Inhibition Model: Comparisons Among Three Methods of Data Analysis

  Tarundeep Kakkar, Harold Boxenbaum and Michael Mayersohn

  Drug Metabolism and Disposition June 1999, 27 (6) 756-762;