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Drug Metabolism & Disposition

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Table of Contents

June 01, 1999; Volume 27,Issue 6

Articles

  • You have access
    The Disposition of 14C-Labeled Tacrolimus after Intravenous and Oral Administration in Healthy Human Subjects
    A. Möller, K. Iwasaki, A. Kawamura, Y. Teramura, T. Shiraga, T. Hata, A. Schäfer and N. A. Undre
    Drug Metabolism and Disposition June 1999, 27 (6) 633-636;
  • You have access
    Correlation of Biliary Excretion in Sandwich-Cultured Rat Hepatocytes and In Vivo in Rats
    Xingrong Liu, Jack P. Chism, Edward L. LeCluyse, Kenneth R. Brouwer and Kim L.R. Brouwer
    Drug Metabolism and Disposition June 1999, 27 (6) 637-644;
  • You have access
    Comparative Pharmacokinetics and Tissue Distribution of the d-Enantiomers of Para-Substituted Methylphenidate Analogs
    Dung L. Thai, Linda N. Yurasits, George R. Rudolph and James M. Perel
    Drug Metabolism and Disposition June 1999, 27 (6) 645-650;
  • You have access
    Dihydropyrimidine Dehydrogenase Activity and Fluorouracil Pharmacokinetics with Liver Damage Induced by Bile Duct Ligation in Rats
    Tomonori Tateishi, Minoru Watanabe, Hironori Nakura, Masami Tanaka, Toshio Kumai, Shigeko Fujimoto Sakata, Nanaya Tamaki, Kenichiro Ogura, Takahito Nishiyama, Tadashi Watabe and Shinichi Kobayashi
    Drug Metabolism and Disposition June 1999, 27 (6) 651-654;
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    Development of a Substrate-Activity Based Approach To Identify the Major Human Liver P-450 Catalysts of Cyclophosphamide and Ifosfamide Activation Based on cDNA-Expressed Activities and Liver Microsomal P-450 Profiles
    Partha Roy, Li J. Yu, Charles L. Crespi and David J. Waxman
    Drug Metabolism and Disposition June 1999, 27 (6) 655-666;
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    Molecular Basis for Hepatic Detoxifying Enzyme Induction by 2-(Allylthio)pyrazine in Rats in Comparison with Oltipraz: Effects on Prooxidant Production and DNA Degradation
    Sang Geon Kim, Min Kyung Cho, Sung Hee Choi, Hye Jung Kim, Mi Kyong Kwak and Nak Doo Kim
    Drug Metabolism and Disposition June 1999, 27 (6) 667-673;
  • You have access
    Comparative Disposition of the NephrotoxicantN-(3,5-Dichlorophenyl)Succinimide and the Non-Nephrotoxicant N-(3,5-Difluorophenyl)Succinimide in Fischer 344 Rats
    Caroline M. Henesey, Ginny L. Kellner-Weibel, Joan B. Tarloff and Peter J. Harvison
    Drug Metabolism and Disposition June 1999, 27 (6) 674-680;
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    Cytochrome P-450 3A and 2D6 Catalyze OrthoHydroxylation of 4-Hydroxytamoxifen and 3-Hydroxytamoxifen (Droloxifene) Yielding Tamoxifen Catechol: Involvement of Catechols in Covalent Binding to Hepatic Proteins
    Shangara S. Dehal and David Kupfer
    Drug Metabolism and Disposition June 1999, 27 (6) 681-688;
  • You have access
    Effect of PSC 833, a P-Glycoprotein Modulator, on the Disposition of Vincristine and Digoxin in Rats
    SaeHeum Song, Hiroshi Suzuki, Ryosei Kawai and Yuichi Sugiyama
    Drug Metabolism and Disposition June 1999, 27 (6) 689-694;
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    Effect of Leptin on Cytochrome P-450, Conjugation, and Antioxidant Enzymes in the ob/ob Mouse
    Angela M. Watson, Samuel M. Poloyac, Georgette Howard and Robert A. Blouin
    Drug Metabolism and Disposition June 1999, 27 (6) 695-700;
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    Cardiovascular Effect and Simultaneous Pharmacokinetic and Pharmacodynamic Modeling of Pimobendan in Healthy Normal Subjects
    Kai-Min Chu, Oliver Yoa-Pu Hu and Shyh-Ming Shieh
    Drug Metabolism and Disposition June 1999, 27 (6) 701-709;
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    Pharmacokinetic Changes of a New Carbapenem, DA-1131, after Intravenous Administration to Spontaneously Hypertensive Rats and Deoxycorticosterone Acetate-Salt-Induced Hypertensive Rats
    So H. Kim, Won B. Kim and Myung G. Lee
    Drug Metabolism and Disposition June 1999, 27 (6) 710-716;
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    Lack of Single-Dose Disulfiram Effects on Cytochrome P-450 2C9, 2C19, 2D6, and 3A4 Activities: Evidence for Specificity Toward P-450 2E1
    Evan D. Kharasch, Douglas C. Hankins, Carole Jubert, Kenneth E. Thummel and Julie K. Taraday
    Drug Metabolism and Disposition June 1999, 27 (6) 717-723;
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    Panipenem, A Carbapenem Antibiotic, Enhances the Glucuronidation of Intravenously Administered Valproic Acid in Rats
    Naotoshi Yamamura, Kaoru Imura, Hideo Naganuma and Kenji Nishimura
    Drug Metabolism and Disposition June 1999, 27 (6) 724-730;
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    Deposition of [3H]Cocaine, [3H]Nicotine, and [3H]Flunitrazepam in Mouse Hair Melanosomes after Systemic Administration
    Peter R. Stout and James A. Ruth
    Drug Metabolism and Disposition June 1999, 27 (6) 731-735;
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    Presystemic Metabolism of Albendazole: Experimental Evidence of an Efflux Process of Albendazole Sulfoxide to Intestinal Lumen
    P. A. Redondo, A. I. Álvarez, J. L. Garcia, O. M. Larrodé, G. Merino and J. G. Prieto
    Drug Metabolism and Disposition June 1999, 27 (6) 736-740;
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    Mechanism-Based Inactivation of Rat Liver Cytochrome P-450 2B1 by 2-Methoxy-5-nitrobenzyl Bromide
    Arthur P. Armstrong and Paul F. Hollenberg
    Drug Metabolism and Disposition June 1999, 27 (6) 741-745;
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    The Multiple Indicator-Dilution Method for the Study of Enzyme Heterogeneity in Liver: Theoretical Basis
    Andreas J. Schwab and K. Sandy Pang
    Drug Metabolism and Disposition June 1999, 27 (6) 746-755;
  • You have access
    Estimation of K i in a Competitive Enzyme-Inhibition Model: Comparisons Among Three Methods of Data Analysis
    Tarundeep Kakkar, Harold Boxenbaum and Michael Mayersohn
    Drug Metabolism and Disposition June 1999, 27 (6) 756-762;
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In this issue

Drug Metabolism and Disposition: 27 (6)
Drug Metabolism and Disposition
Vol. 27, Issue 6
1 Jun 1999
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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