Drug Metabolism and Disposition: 27 (6)

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About the cover: A, BSO effects on oltipraz- or 2-(allylthio)pyrazine-inducible mEH and rGSTA2 mRNAs. B, the inhibition of oltipraz- or 2-(allylthio)pyrazine-inducible mEH and rGSTA2 mRNA expression by cysteine. See the article by Kim et al. in this issue on page 667.

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

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