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Research ArticleArticle

Dihydropyrimidine Dehydrogenase Activity and Fluorouracil Pharmacokinetics with Liver Damage Induced by Bile Duct Ligation in Rats

Tomonori Tateishi, Minoru Watanabe, Hironori Nakura, Masami Tanaka, Toshio Kumai, Shigeko Fujimoto Sakata, Nanaya Tamaki, Kenichiro Ogura, Takahito Nishiyama, Tadashi Watabe and Shinichi Kobayashi
Drug Metabolism and Disposition June 1999, 27 (6) 651-654;

Article Information

vol. 27 no. 6 651-654
PubMed 
10348793
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 4, 1998
  • Accepted February 24, 1999
  • Published online June 1, 1999.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Tomonori Tateishi1,
  2. Minoru Watanabe1,
  3. Hironori Nakura1,
  4. Masami Tanaka1,
  5. Toshio Kumai1,
  6. Shigeko Fujimoto Sakata2,
  7. Nanaya Tamaki2,
  8. Kenichiro Ogura3,
  9. Takahito Nishiyama3,
  10. Tadashi Watabe3 and
  11. Shinichi Kobayashi1
  1. 1Department of Pharmacology, St. Marianna University School of Medicine, Kanagawa, Japan (T.T., M.W., H.N., M.T., T.K., S.K.); 2Faculty of Nutrition, Kobe Gakuin University, Kobe, Japan (S.F.S., N.T.); and 3Department of Drug Metabolism and Molecular Toxicology, School of Pharmacy (K.O., T.N., T.W.), Tokyo University of Pharmacy and Life Science, Tokyo, Japan
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    Research ArticleArticle

    Dihydropyrimidine Dehydrogenase Activity and Fluorouracil Pharmacokinetics with Liver Damage Induced by Bile Duct Ligation in Rats

    Tomonori Tateishi, Minoru Watanabe, Hironori Nakura, Masami Tanaka, Toshio Kumai, Shigeko Fujimoto Sakata, Nanaya Tamaki, Kenichiro Ogura, Takahito Nishiyama, Tadashi Watabe and Shinichi Kobayashi
    Drug Metabolism and Disposition June 1, 1999, 27 (6) 651-654;
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