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Cytochrome P-450 3A and 2D6 Catalyze OrthoHydroxylation of 4-Hydroxytamoxifen and 3-Hydroxytamoxifen (Droloxifene) Yielding Tamoxifen Catechol: Involvement of Catechols in Covalent Binding to Hepatic Proteins

Shangara S. Dehal and David Kupfer
Drug Metabolism and Disposition June 1999, 27 (6) 681-688;

Article Information

vol. 27 no. 6 681-688
PubMed 
10348797
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 16, 1998
  • Accepted February 24, 1999
  • Published online June 1, 1999.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Shangara S. Dehal and
  2. David Kupfer
  1. Worcester Foundation for Biomedical Research and Department of Pharmacology and Molecular Toxicology, University of Massachusetts Medical Center, Worcester, Massachusetts
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    Research ArticleArticle

    Cytochrome P-450 3A and 2D6 Catalyze OrthoHydroxylation of 4-Hydroxytamoxifen and 3-Hydroxytamoxifen (Droloxifene) Yielding Tamoxifen Catechol: Involvement of Catechols in Covalent Binding to Hepatic Proteins

    Shangara S. Dehal and David Kupfer
    Drug Metabolism and Disposition June 1, 1999, 27 (6) 681-688;
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