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Drug Metabolism & Disposition

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Table of Contents

July 01, 1999; Volume 27,Issue 7

Short Communications

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    Sertraline N-Demethylation Is Catalyzed by Multiple Isoforms of Human Cytochrome P-450 In Vitro
    Kaoru Kobayashi, Tomoko Ishizuka, Noriaki Shimada, Yoshitaka Yoshimura, Kunitoshi Kamijima and Kan Chiba
    Drug Metabolism and Disposition July 1999, 27 (7) 763-766;
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    Reductive Metabolism In Vivo ofTrans-4-Phenyl-3-buten-2-one in Rats and Dogs
    Shigeyuki Kitamura, Yuji Okamoto, Mitsuhiro Takeshita and Shigeru Ohta
    Drug Metabolism and Disposition July 1999, 27 (7) 767-769;

Articles

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    Potent Inhibition of Cytochrome P-450 2D6-Mediated Dextromethorphan O-Demethylation by Terbinafine
    Susan M. Abdel-Rahman, Kenda Marcucci, Thomas Boge, R. Russell Gotschall, Gregory L. Kearns and J. Steven Leeder
    Drug Metabolism and Disposition July 1999, 27 (7) 770-775;
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    An In Vitro Study on the Metabolism and Possible Drug Interactions of Rokitamycin, a Macrolide Antibiotic, Using Human Liver Microsomes
    Xue-Jun Zhao, Eriko Koyama and Takashi Ishizaki
    Drug Metabolism and Disposition July 1999, 27 (7) 776-785;
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    Covalent Sequestration of Phosphoramide Mustard by Metallothionein—An In Vitro Study
    Dong Wei, Daniele Fabris and Catherine Fenselau
    Drug Metabolism and Disposition July 1999, 27 (7) 786-791;
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    Inhibitory Effects of Azelastine and Its Metabolites on Drug Oxidation Catalyzed by Human Cytochrome P-450 Enzymes
    Miki Nakajima, Katsuhiro Ohyama, Sumika Nakamura, Noriaki Shimada, Hiroshi Yamazaki and Tsuyoshi Yokoi
    Drug Metabolism and Disposition July 1999, 27 (7) 792-797;
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    Specific Dehydrogenation of 3-Methylindole and Epoxidation of Naphthalene by Recombinant Human CYP2F1 Expressed in Lymphoblastoid Cells
    Diane L. Lanza, Erin Code, Charles L. Crespi, Frank J. Gonzalez and Garold S. Yost
    Drug Metabolism and Disposition July 1999, 27 (7) 798-803;
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    Characterization of Human Small Intestinal Cytochromes P-450
    Qing-Yu Zhang, Deborah Dunbar, Alina Ostrowska, Stephen Zeisloft, Jiang Yang and Laurence S. Kaminsky
    Drug Metabolism and Disposition July 1999, 27 (7) 804-809;
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    Absorption, Excretion, and Metabolism of the Endothelin Receptor Antagonist Bosentan in Healthy Male Subjects
    Cornelia Weber, Rodolfo Gasser and G. Hopfgartner
    Drug Metabolism and Disposition July 1999, 27 (7) 810-815;
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    Prediction of the Systemic Exposure to Oral 9-Amino-20(S)-Camptothecin Using Single-Sample Analysis
    Alex Sparreboom, Maja J. A. de Jonge, Cornelis J. A. Punt, Walter J. Loos, Kees Nooter, Gerrit Stoter, Maria Grazia Porro and Jaap Verweij
    Drug Metabolism and Disposition July 1999, 27 (7) 816-820;
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    Intracoronary and Intravenous Administration of Basic Fibroblast Growth Factor: Myocardial and Tissue Distribution
    Roger J. Laham, Mehrdad Rezaee, Mark Post, Frank W. Sellke, Rene A. Braeckman, David Hung and Michael Simons
    Drug Metabolism and Disposition July 1999, 27 (7) 821-826;
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    Effects of a Potent and Specific P-Glycoprotein Inhibitor on the Blood-Brain Barrier Distribution and Antinociceptive Effect of Morphine in the Rat
    Stephen P. Letrent, Gary M. Pollack, Kenneth R. Brouwer and Kim L.R. Brouwer
    Drug Metabolism and Disposition July 1999, 27 (7) 827-834;
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    Metabolism of Diallyl Disulfide by Human Liver Microsomal Cytochromes P-450 and Flavin-Containing Monooxygenases
    Caroline Teyssier, Lucien Guenot, Marc Suschetet and Marie-Hélène Siess
    Drug Metabolism and Disposition July 1999, 27 (7) 835-841;
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    Comparison of Human and Rat Metabolism of Molinate in Liver Microsomes and Slices
    William T. Jewell and Marion G. Miller
    Drug Metabolism and Disposition July 1999, 27 (7) 842-847;
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    Identification of Urinary Metabolites of Isoprene in Rats and Comparison with Mouse Urinary Metabolites
    Lorrene A. Buckley, Donna P. Coleman, Jason P. Burgess, Brian F. Thomas, Leo T. Burka and A. Robert Jeffcoat
    Drug Metabolism and Disposition July 1999, 27 (7) 848-854;
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In this issue

Drug Metabolism and Disposition: 27 (7)
Drug Metabolism and Disposition
Vol. 27, Issue 7
1 Jul 1999
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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