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Drug Metabolism & Disposition

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Table of Contents

August 01, 1999; Volume 27,Issue 8

Short Communication

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    A Double-Peak Phenomenon in the Pharmacokinetics of Alprazolam after Oral Administration
    Yunxia Wang, Amit Roy, Lei Sun and Chyan E. Lau
    Drug Metabolism and Disposition August 1999, 27 (8) 855-859;

Articles

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    Involvement of CYP2E1 as A Low-Affinity Enzyme in Phenacetin O-Deethylation in Human Liver Microsomes
    Kaoru Kobayashi, Miki Nakajima, Kanako Oshima, Noriaki Shimada, Tsuyoshi Yokoi and Kan Chiba
    Drug Metabolism and Disposition August 1999, 27 (8) 860-865;
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    OATP and P-Glycoprotein Transporters Mediate the Cellular Uptake and Excretion of Fexofenadine
    Mirjana Cvetkovic, Brenda Leake, Martin F. Fromm, Grant R. Wilkinson and Richard B. Kim
    Drug Metabolism and Disposition August 1999, 27 (8) 866-871;
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    Canalicular Membrane Transport Is Primarily Responsible for the Difference in Hepatobiliary Excretion of Triethylmethylammonium and Tributylmethylammonium in Rats
    Yong-Hae Han, Suk-Jae Chung and Chang-Koo Shim
    Drug Metabolism and Disposition August 1999, 27 (8) 872-879;
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    Flavin-Containing Monooxygenase-Mediated Metabolism ofN-Deacetyl Ketoconazole by Rat Hepatic Microsomes
    Rosita J. Rodriguez, Philip J. Proteau, Brian L. Marquez, Craig L. Hetherington, Cheryl J. Buckholz and Kerry L. O’Connell
    Drug Metabolism and Disposition August 1999, 27 (8) 880-886;
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    The Use of Human Hepatocyte Cultures to Study the Induction of Cytochrome P-450
    Vsevolod E. Kostrubsky, Vinod Ramachandran, Raman Venkataramanan, Kenneth Dorko, James E. Esplen, Shimin Zhang, Jacqueline F. Sinclair, Steven A. Wrighton and Stephen C. Strom
    Drug Metabolism and Disposition August 1999, 27 (8) 887-894;
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    Disposition and Biotransformation of the Antiretroviral Drug Nevirapine in Humans
    Paul Riska, Michael Lamson, Thomas MacGregor, John Sabo, Susan Hattox, Joseph Pav and James Keirns
    Drug Metabolism and Disposition August 1999, 27 (8) 895-901;
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    Potent Inhibition of the Cytochrome P-450 3A-Mediated Human Liver Microsomal Metabolism of a Novel HIV Protease Inhibitor by Ritonavir: A Positive Drug-Drug Interaction
    Gondi N. Kumar, Jennifer Dykstra, Ellen M. Roberts, Venkata K. Jayanti, Dean Hickman, John Uchic, Ye Yao, Bruce Surber, Samuel Thomas and G. Richard Granneman
    Drug Metabolism and Disposition August 1999, 27 (8) 902-908;
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    Influence of Extracellular Matrix Overlay and Medium Formulation on the Induction of Cytochrome P-450 2B Enzymes in Primary Cultures of Rat Hepatocytes
    Edward LeCluyse, Peter Bullock, Ajay Madan, Kathy Carroll and Andrew Parkinson
    Drug Metabolism and Disposition August 1999, 27 (8) 909-915;
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    Metabolism and Excretion of Atorvastatin in Rats And Dogs
    Ann E. Black, Roger N. Hayes, Bruce D. Roth, Peter Woo and Thomas F. Woolf
    Drug Metabolism and Disposition August 1999, 27 (8) 916-923;
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    Characterization of Cytochrome P-450 2D1 Activity in Rat Brain: High-Affinity Kinetics for Dextromethorphan
    Rachel F. Tyndale, Yan Li, Ning-Yuan Li, Erasmo Messina, Sharon Miksys and Edward M. Sellers
    Drug Metabolism and Disposition August 1999, 27 (8) 924-930;
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    Inhibition of Esterolysis of Enalapril by Paraoxon Increases the Urinary Clearance in Isolated Perfused Rat Kidney
    Gina L. Sirianni and K. Sandy Pang
    Drug Metabolism and Disposition August 1999, 27 (8) 931-936;
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    Modulation of Multidrug Resistance Protein Expression in Porcine Brain Capillary Endothelial Cells In Vitro
    Heike Gutmann, Michael Török, Gert Fricker, Jörg Huwyler, Christoph Beglinger and Jürgen Drewe
    Drug Metabolism and Disposition August 1999, 27 (8) 937-941;
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    In Vitro Identification of the Human Cytochrome P-450 Enzymes Involved in the N-Demethylation of Azelastine
    Teruko Imai, Megumi Taketani, Tomoko Suzu, Kenichi Kusube and Masaki Otagiri
    Drug Metabolism and Disposition August 1999, 27 (8) 942-946;
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    Disposition of Cosalane, a Novel Anti-HIV Agent, in Isolated Perfused Rat Livers
    Chandrasekhar Udata, Ashim K. Mitra and Mostafa Z. Badr
    Drug Metabolism and Disposition August 1999, 27 (8) 947-950;
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    Repeated Oral Rifampicin Decreases the Jejunal Permeability of R/S-Verapamil in Rats
    Rikard Sandström and Hans Lennernäs
    Drug Metabolism and Disposition August 1999, 27 (8) 951-955;
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In this issue

Drug Metabolism and Disposition: 27 (8)
Drug Metabolism and Disposition
Vol. 27, Issue 8
1 Aug 1999
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  • Short Communication
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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