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Research ArticleArticle

Potent Inhibition of the Cytochrome P-450 3A-Mediated Human Liver Microsomal Metabolism of a Novel HIV Protease Inhibitor by Ritonavir: A Positive Drug-Drug Interaction

Gondi N. Kumar, Jennifer Dykstra, Ellen M. Roberts, Venkata K. Jayanti, Dean Hickman, John Uchic, Ye Yao, Bruce Surber, Samuel Thomas and G. Richard Granneman
Drug Metabolism and Disposition August 1999, 27 (8) 902-908;

Article Information

vol. 27 no. 8 902-908
PubMed 
10421617
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 29, 1999
  • Accepted May 6, 1999
  • Published online August 1, 1999.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Gondi N. Kumar,
  2. Jennifer Dykstra1,
  3. Ellen M. Roberts,
  4. Venkata K. Jayanti,
  5. Dean Hickman,
  6. John Uchic,
  7. Ye Yao,
  8. Bruce Surber,
  9. Samuel Thomas and
  10. G. Richard Granneman
  1. Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois
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    Research ArticleArticle

    Potent Inhibition of the Cytochrome P-450 3A-Mediated Human Liver Microsomal Metabolism of a Novel HIV Protease Inhibitor by Ritonavir: A Positive Drug-Drug Interaction

    Gondi N. Kumar, Jennifer Dykstra, Ellen M. Roberts, Venkata K. Jayanti, Dean Hickman, John Uchic, Ye Yao, Bruce Surber, Samuel Thomas and G. Richard Granneman
    Drug Metabolism and Disposition August 1, 1999, 27 (8) 902-908;
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