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Drug Metabolism & Disposition

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Table of Contents

September 01, 1999; Volume 27,Issue 9

1998 INTERNATIONAL MEETING ON THE ARYLAMINE N-ACETYLTRANSFERASES

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    Synopsis of the Workshop on Nomenclature, Biochemistry, Molecular Biology, Interspecies Comparisons, and Role in Human Disease Risk
    Kenneth F. Ilett, Fred F. Kadlubar and Rodney F. Minchin
    Drug Metabolism and Disposition September 1999, 27 (9) 957-959;

Articles

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    Cytochrome CYP Sources of N-Alkylprotoporphyrin IX after Administration of Porphyrinogenic Xenobiotics to Rats
    Simon G. W. Wong, Eva H. Lin and Gerald S. Marks
    Drug Metabolism and Disposition September 1999, 27 (9) 960-965;
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    N-Acetylation of the Heterocyclic Amine Batracylin by Human Liver
    Gregory J. Stevens, Mark Payton, Edith Sim and Charlene A. McQueen
    Drug Metabolism and Disposition September 1999, 27 (9) 966-971;
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    Modulation of Rat Cytochrome P-450 by an Investigational HIV Protease Inhibitor
    Joy A. Nishime, Regina W. Wang, Jiunn H. Lin and Masato Chiba
    Drug Metabolism and Disposition September 1999, 27 (9) 972-976;
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    Dose-Dependent Up-Regulation of Rat Pulmonary, Renal, and Hepatic Cytochrome P-450 (CYP) 1A Expression by Nicotine Feeding
    Michael M. Iba, Jacqueline Fung, Yang Won Pak, Paul E. Thomas, Hans Fisher, Anna Sekowski, Alycia K. Halladay and George C. Wagner
    Drug Metabolism and Disposition September 1999, 27 (9) 977-982;
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    Metabolism of Antitumor Hydroxymethylacylfulvene by Rat Liver Cytosol
    Trevor C. McMorris, Anissa N. Elayadi, Jian Yu, Yi Hu and Michael J. Kelner
    Drug Metabolism and Disposition September 1999, 27 (9) 983-985;
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    Activated Sulfonamides are Cleaved by Glutathione-S-Transferases
    Kenneth A. Koeplinger, Zhiyang Zhao, Tillie Peterson, Joseph W. Leone, Francis S. Schwende, Robert L. Heinrikson and Alfredo G. Tomasselli
    Drug Metabolism and Disposition September 1999, 27 (9) 986-991;
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    Mechanism, Structure-Activity Studies, and Potential Applications of Glutathione S-Transferase-Catalyzed Cleavage of Sulfonamides
    Zhiyang Zhao, Kenneth A. Koeplinger, Tillie Peterson, Robert A. Conradi, Philip S. Burton, Antonino Suarato, Robert L. Heinrikson and Alfredo G. Tomasselli
    Drug Metabolism and Disposition September 1999, 27 (9) 992-998;
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    Enhancement of Cytochrome P-450 3A4 Catalytic Activities by Cytochrome b 5 in Bacterial Membranes
    Hiroshi Yamazaki, Miki Nakajima, Mami Nakamura, Satoru Asahi, Noriaki Shimada, Elizabeth M. J. Gillam, F. Peter Guengerich, Tsutomu Shimada and Tsuyoshi Yokoi
    Drug Metabolism and Disposition September 1999, 27 (9) 999-1004;
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    The Reductive Metabolism of Nitric Oxide in Hepatocytes: Possible Interaction with Thiols
    Jinjoo Hyun, Gautam Chaudhuri and Jon M. Fukuto
    Drug Metabolism and Disposition September 1999, 27 (9) 1005-1009;
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    Glucuronidation of the Lung Carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) by Rat UDP-Glucuronosyltransferase 2B1
    Qing Ren, Sharon E. Murphy, Andrew J. Dannenberg, Jong Y. Park, Thomas R. Tephly and Philip Lazarus
    Drug Metabolism and Disposition September 1999, 27 (9) 1010-1016;
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    Rapid Characterization of the Major Drug-Metabolizing Human Hepatic Cytochrome P-450 Enzymes Expressed in Escherichia coli
    Dermot F. McGinnity, Sarah J. Griffin, Graeme C. Moody, Mike Voice, Stephen Hanlon, Thomas Friedberg and Robert J. Riley
    Drug Metabolism and Disposition September 1999, 27 (9) 1017-1023;
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    The Role of CYP2C19 in the Metabolism of (+/−) Bufuralol, the Prototypic Substrate of CYP2D6
    Dayna C. Mankowski
    Drug Metabolism and Disposition September 1999, 27 (9) 1024-1028;
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    Multiple Cytochrome P-450s Involved in the Metabolism of Terbinafine Suggest a Limited Potential for Drug-Drug Interactions
    Alison E. M. Vickers, John R. Sinclair, Markus Zollinger, Francis Heitz, Ulrike Glänzel, Laurie Johanson and Volker Fischer
    Drug Metabolism and Disposition September 1999, 27 (9) 1029-1038;
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    Oxidative Metabolism of Monensin in Rat Liver Microsomes and Interactions with Tiamulin and Other Chemotherapeutic Agents: Evidence for the Involvement of Cytochrome P-450 3A Subfamily
    Carlo Nebbia, Luciano Ceppa, Mauro Dacasto, Monica Carletti and Carlo Nachtmann
    Drug Metabolism and Disposition September 1999, 27 (9) 1039-1044;
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    Liquid Chromatography/Mass Spectrometry and High-Field Nuclear Magnetic Resonance Characterization of Novel Mixed Diconjugates of the Non-nucleoside Human Immunodeficiency Virus-1 Reverse Transcriptase Inhibitor, Efavirenz
    A. E. Mutlib, H. Chen, G. Nemeth, L.-S. Gan and D. D. Christ
    Drug Metabolism and Disposition September 1999, 27 (9) 1045-1056;
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    Studies on Sulfation of Synthesized Metabolites from the Local Anesthetics Ropivacaine and Lidocaine Using Human Cloned Sulfotransferases
    Charles N. Falany, Josie L. Falany, Jin Wang, Johan Hedström, Hans von Euler Chelpin and Stellan Swedmark
    Drug Metabolism and Disposition September 1999, 27 (9) 1057-1063;
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    Human and Escherichia coliβ-Glucuronidase Hydrolysis of Glucuronide Conjugates of Benzidine and 4-Aminobiphenyl, and their Hydroxy Metabolites
    Terry V. Zenser, Vijaya M. Lakshmi and Bernard B. Davis
    Drug Metabolism and Disposition September 1999, 27 (9) 1064-1067;
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    Cytochrome P-450 3A4 and 2C8 Are Involved in Zopiclone Metabolism
    Laurent Becquemont, Said Mouajjah, Olivier Escaffre, Philippe Beaune, Christian Funck-Brentano and Patrice Jaillon
    Drug Metabolism and Disposition September 1999, 27 (9) 1068-1073;
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    Effect of the Acute-Phase Response on the Pharmacokinetics of Chlorzoxazone and Cytochrome P-450 2E1 In Vitro Activity in Rats
    Kevin Rockich and Robert Blouin
    Drug Metabolism and Disposition September 1999, 27 (9) 1074-1077;
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    Effect of Antipsychotic Drugs on Human Liver Cytochrome P-450 (CYP) Isoforms In Vitro: Preferential Inhibition of CYP2D6
    Jae-Gook Shin, Nadia Soukhova and David A. Flockhart
    Drug Metabolism and Disposition September 1999, 27 (9) 1078-1084;
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    Absence of Host-Site Influence on Angiogenesis, Blood Flow, and Permeability in Transplanted RG-2 Gliomas
    Peter Molnar, Istvan Fekete, Kurt E. Schlageter, Gregory D. Lapin and Dennis R. Groothuis
    Drug Metabolism and Disposition September 1999, 27 (9) 1085-1091;
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    Diurnal Variation in the Metabolism ofS-Carboxymethyl-l-Cysteine in Humans
    Glyn B. Steventon
    Drug Metabolism and Disposition September 1999, 27 (9) 1092-1097;
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Drug Metabolism and Disposition: 27 (9)
Drug Metabolism and Disposition
Vol. 27, Issue 9
1 Sep 1999
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  • 1998 INTERNATIONAL MEETING ON THE ARYLAMINE N-ACETYLTRANSFERASES
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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