Table of Contents

Articles

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  In Vivo Metabolism and Mass Balance of 4-[4-Fluorophenoxy]benzaldehyde Semicarbazone in Rats

  Kumar Ramu, Gilbert N. Lam and Helen Hughes

  Drug Metabolism and Disposition October 2000, 28 (10) 1153-1161;
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  Tissue Distribution and Biotransformation of Potassium Oxonate after Oral Administration of a Novel Antitumor Agent (Drug Combination of Tegafur, 5-Chloro-2,4-dihydroxypyridine, and Potassium Oxonate) to Rats

  Kunihiro Yoshisue, Hirotoshi Masuda, Eiji Matsushima, Kazumasa Ikeda, Sekio Nagayama and Yasuro Kawaguchi

  Drug Metabolism and Disposition October 2000, 28 (10) 1162-1167;
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  Metabolism of the Antidepressant Mirtazapine In Vitro: Contribution of Cytochromes P-450 1A2, 2D6, and 3A4

  Elke Störmer, Lisa L. von Moltke, Richard I. Shader and David J. Greenblatt

  Drug Metabolism and Disposition October 2000, 28 (10) 1168-1175;
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  CYP2B6 Mediates the In Vitro Hydroxylation of Bupropion: Potential Drug Interactions with Other Antidepressants

  Leah M. Hesse, Karthik Venkatakrishnan, Michael H. Court, Lisa L. von Moltke, Su X. Duan, Richard I. Shader and David J. Greenblatt

  Drug Metabolism and Disposition October 2000, 28 (10) 1176-1183;
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  A Highly Sensitive Fluorescent Microplate Method for the Determination of UDP-Glucuronosyl Transferase Activity in Tissues and Placental Cell Lines

  Abby C. Collier, Malcolm D. Tingle, Jeffrey A. Keelan, James W. Paxton and Murray D. Mitchell

  Drug Metabolism and Disposition October 2000, 28 (10) 1184-1186;
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  (R)-, (S)-, and Racemic Fluoxetine N-Demethylation by Human Cytochrome P450 Enzymes

  Jeannine M. Margolis, John P. O'Donnell, Dayna C. Mankowski, Sean Ekins and R. Scott Obach

  Drug Metabolism and Disposition October 2000, 28 (10) 1187-1191;
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  The Role of Conjugation in Hepatotoxicity of Troglitazone in Human and Porcine Hepatocyte Cultures

  Vsevolod E. Kostrubsky, Jacqueline F. Sinclair, Vinod Ramachandran, Raman Venkataramanan, Yuan Hua Wen, Erick Kindt, Vladimir Galchev, Kelly Rose, Michael Sinz and Stephen C. Strom

  Drug Metabolism and Disposition October 2000, 28 (10) 1192-1197;
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  Topological Alteration of the CYP3A4 Active Site by the Divalent Cation Mg²⁺

  Michael L. Schrag and Larry C. Wienkers

  Drug Metabolism and Disposition October 2000, 28 (10) 1198-1201;
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  Differential Maintenance of Cytochrome P450 Enzymes in Cultured Precision-Cut Human Liver Slices

  Anthony B. Renwick, Patricia S. Watts, Robert J. Edwards, Paula T. Barton, Isabelle Guyonnet, Roger J. Price, J. Michael Tredger, Olavi Pelkonen, Alan R. Boobis and Brian G. Lake

  Drug Metabolism and Disposition October 2000, 28 (10) 1202-1209;
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  Glucuronidation of Estrogens and Retinoic Acid and Expression of UDP-Glucuronosyltransferase 2B7 in Human Intestinal Mucosa

  Piotr J. Czernik, Joanna M. Little, Gary W. Barone, Jean-Pierre Raufman and Anna Radominska-Pandya

  Drug Metabolism and Disposition October 2000, 28 (10) 1210-1216;
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  Impaired Elimination of Propranolol Due to Right Heart Failure: Drug Clearance in the Isolated Liver and Its Relationship to Intrinsic Metabolic Capacity

  Connie Y. Ng, Hany Ghabrial, Denis J. Morgan, Michael S. Ching, Richard A. Smallwood and Peter W. Angus

  Drug Metabolism and Disposition October 2000, 28 (10) 1217-1221;
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  Validation of Bupropion Hydroxylation as a Selective Marker of Human Cytochrome P450 2B6 Catalytic Activity

  Stephanie R. Faucette, Roy L. Hawke, Edward L. Lecluyse, Stacy S. Shord, Bingfang Yan, Ronald M. Laethem and Celeste M. Lindley

  Drug Metabolism and Disposition October 2000, 28 (10) 1222-1230;
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  The Involvement of Flavin-Containing Monooxygenase but Not CYP3A4 in Metabolism of Itopride Hydrochloride, a Gastroprokinetic Agent: Comparison with Cisapride and Mosapride Citrate

  Taisei Mushiroda, Rika Douya, Eiji Takahara and Osamu Nagata

  Drug Metabolism and Disposition October 2000, 28 (10) 1231-1237;
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  Selective Inhibition of Human Cytochrome P450 3A4 byN-[2(R)-Hydroxy-1(S)-indanyl]-5-[2(S)-(1,1-dimethylethylaminocarbonyl)-4-[(furo[2,3-b]pyridin-5-yl)methyl]piperazin-1-yl]-4(S)-hydroxy-2(R)-phenylmethylpentanamide and P-glycoprotein by Valspodar in Gene Transfectant Systems

  Iichiro Kawahara, Yukio Kato, Hiroshi Suzuki, Meguru Achira, Kiyomi Ito, Charles L. Crespi and Yuichi Sugiyama

  Drug Metabolism and Disposition October 2000, 28 (10) 1238-1243;
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  The Absorption, Distribution, Metabolism and Excretion of Rofecoxib, a Potent and Selective Cyclooxygenase-2 Inhibitor, in Rats and Dogs

  Rita A. Halpin, Leslie A. Geer, Kanyin E. Zhang, Tina M. Marks, Dennis C. Dean, Allen N. Jones, David Melillo, George Doss and Kamlesh P. Vyas

  Drug Metabolism and Disposition October 2000, 28 (10) 1244-1254;
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  Disposition and Toxicity of a Mixed Backbone Antisense Oligonucleotide, Targeted against Human Cytomegalovirus, after Intravitreal Injection of Escalating Single Doses in the Rabbit

  Barry H. Dvorchik and Judith K. Marquis

  Drug Metabolism and Disposition October 2000, 28 (10) 1255-1261;