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Drug Metabolism & Disposition

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Table of Contents

November 01, 2000; Volume 28,Issue 11

Short Communications

  • You have access
    Specificity of Cytochrome P450 2A3-Catalyzed α-Hydroxylation ofN′-Nitrosonornicotine Enantiomers
    Sharon E. Murphy, Issa S. Isaac, Xinxin Ding and Edward J. McIntee
    Drug Metabolism and Disposition November 2000, 28 (11) 1263-1266;
  • You have access
    Chronic Nifedipine Dosing Enhances Cephalexin Bioavailability and Intestinal Absorption in Conscious Rats
    F. Berlioz, B. Lepére-Prevot, S. Julien, A. Tsocas, C. Carbon, C. Rozé and R. Farinotti
    Drug Metabolism and Disposition November 2000, 28 (11) 1267-1269;
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    Milk Thistle, a Herbal Supplement, Decreases the Activity of CYP3A4 and Uridine Diphosphoglucuronosyl Transferase in Human Hepatocyte Cultures
    Raman Venkataramanan, Vinod Ramachandran, Bernard J. Komoroski, Shimin Zhang, Paul L. Schiff and Stephen C. Strom
    Drug Metabolism and Disposition November 2000, 28 (11) 1270-1273;
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    Metabolites of Caspofungin Acetate, a Potent Antifungal Agent, in Human Plasma and Urine
    Suresh K. Balani, Xin Xu, Byron H. Arison, Maria V. Silva, Amy Gries, Florencia A. DeLuna, Donghui Cui, Prasad H. Kari, Trung Ly, Cornelis E. C. A. Hop, Rominder Singh, Michael A. Wallace, Dennis C. Dean, Jiunn H. Lin, Paul G. Pearson and Thomas A. Baillie
    Drug Metabolism and Disposition November 2000, 28 (11) 1274-1278;

Articles

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    Heterologous Expression of Cyp2k1 and Identification of the Expressed Protein (bv-Cyp2k1) As Lauric Acid (ω-1)-Hydroxylase and Aflatoxin B1exo-Epoxidase
    Yea-Huey Yang, Cristobal L. Miranda, Marilyn C. Henderson, Jun-Lan Wang-Buhler and Donald R. Buhler
    Drug Metabolism and Disposition November 2000, 28 (11) 1279-1283;
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    Cytochrome P4502C9 Is the Principal Catalyst of Racemic Acenocoumarol Hydroxylation Reactions in Human Liver Microsomes
    Henk H. Thijssen, Jean-Pierre Flinois and Phillippe H. Beaune
    Drug Metabolism and Disposition November 2000, 28 (11) 1284-1290;
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    CYP3A4 Is a Major Isoform Responsible for Oxidation of 7-Hydroxy-Δ8-tetrahydrocannabinol to 7-Oxo-Δ8-tetrahydrocannabinol in Human Liver Microsomes
    Tamihide Matsunaga, Nobuyuki Kishi, Shinsuke Higuchi, Kazuhito Watanabe, Tohru Ohshima and Ikuo Yamamoto
    Drug Metabolism and Disposition November 2000, 28 (11) 1291-1296;
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    Prenylflavonoids from Hops Inhibit the Metabolic Activation of the Carcinogenic Heterocyclic Amine 2-Amino-3-methylimidazo[4,5-f]quinoline, Mediated by cDNA-Expressed Human CYP1A2
    Cristobal L. Miranda, Yea-Huey Yang, Marilyn C. Henderson, Jan F. Stevens, Gilberto Santana-Rios, Max L. Deinzer and Donald R. Buhler
    Drug Metabolism and Disposition November 2000, 28 (11) 1297-1302;
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    A Significant Role of Human Cytochrome P450 2C8 in Amiodarone N-Deethylation: An Approach to Predict the Contribution with Relative Activity Factor
    Katsuhiro Ohyama, Miki Nakajima, Sumika Nakamura, Noriaki Shimada, Hiroshi Yamazaki and Tsuyoshi Yokoi
    Drug Metabolism and Disposition November 2000, 28 (11) 1303-1310;
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    Induction of Mouse CYP2J by Pyrazole in the Eye, Kidney, Liver, Lung, Olfactory Mucosa, and Small Intestine, but Not in the Heart
    Qiang Xie, Qing-Yu Zhang, Yan Zhang, Ting Su, Jun Gu, Laurence S. Kaminsky and Xinxin Ding
    Drug Metabolism and Disposition November 2000, 28 (11) 1311-1316;
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    Decreased in Vivo Metabolism of Drugs in Chronic Renal Failure
    François A. Leblond, Lise Giroux, Jean-Pierre Villeneuve and Vincent Pichette
    Drug Metabolism and Disposition November 2000, 28 (11) 1317-1320;
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    CYP2A5/CYP2A6 Expression in Mouse and Human Hepatocytes Treated with Various in Vivo Inducers
    Marı́a Teresa Donato, Pirkko Viitala, Cristina Rodriguez-Antona, Aija Lindfors, Jose V. Castell, Hannu Raunio, Maria Jose Gómez-Lechón and Olavi Pelkonen
    Drug Metabolism and Disposition November 2000, 28 (11) 1321-1326;
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    Automated Definition of the Enzymology of Drug Oxidation by the Major Human Drug Metabolizing Cytochrome P450s
    Dermot F. McGinnity, Alison J. Parker, Matthew Soars and Robert J. Riley
    Drug Metabolism and Disposition November 2000, 28 (11) 1327-1334;
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    Human Serum Paraoxonase (pon1) Isozymes Q and R Hydrolyze Lactones and Cyclic Carbonate Esters
    S. Billecke, D. Draganov, R. Counsell, P. Stetson, C. Watson, C. Hsu and B. N. La Du
    Drug Metabolism and Disposition November 2000, 28 (11) 1335-1342;
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    In Vitro Evaluation of the Disposition of A Novel Cysteine Protease Inhibitor
    Wolfgang Jacobsen, Uwe Christians and Leslie Z. Benet
    Drug Metabolism and Disposition November 2000, 28 (11) 1343-1351;
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    O-Glucuronidation of the Lung Carcinogen 4-(methylnitrosamino)-1- (3-Pyridyl)-1-Butanol (nnal) by Human Udp-Glucuronosyltransferases 2b7 and 1a9
    Qing Ren, Sharon E. Murphy, Zhong Zheng and Philip Lazarus
    Drug Metabolism and Disposition November 2000, 28 (11) 1352-1360;
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    Formation of A Dihydroxy Metabolite of Phenytoin in Human Liver Microsomes/cytosol: Roles of Cytochromes P450 2c9, 2c19, and 3a4
    Tomoko Komatsu, Hiroshi Yamazaki, Satoru Asahi, Elizabeth M. J. Gillam, F. Peter Guengerich, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition November 2000, 28 (11) 1361-1368;
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    Lactonization Is the Critical First Step in the Disposition of the 3-Hydroxy-3-Methylglutaryl-Coa Reductase Inhibitor Atorvastatin
    Wolfgang Jacobsen, Bernd Kuhn, Andrea Soldner, Gabriele Kirchner, Karl-Fr. Sewing, Peter A. Kollman, Leslie Z. Benet and Uwe Christians
    Drug Metabolism and Disposition November 2000, 28 (11) 1369-1378;
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    Early Biotransformations of Oxaliplatin after Its Intravenous Administration to Cancer Patients
    Pierre Allain, Oliver Heudi, Annie Cailleux, Anne Le Bouil, Francis Larra, Michele Boisdron-Celle and Erik Gamelin
    Drug Metabolism and Disposition November 2000, 28 (11) 1379-1384;
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    The Specificity of Glucuronidation of Entacapone and Tolcapone by Recombinant Human Udp-Glucuronosyltransferases
    Pia Lautala, Brian T. Ethell, Jyrki Taskinen and Brian Burchell
    Drug Metabolism and Disposition November 2000, 28 (11) 1385-1389;
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Drug Metabolism and Disposition: 28 (11)
Drug Metabolism and Disposition
Vol. 28, Issue 11
1 Nov 2000
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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