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Research ArticleArticle

Lactonization Is the Critical First Step in the Disposition of the 3-Hydroxy-3-Methylglutaryl-Coa Reductase Inhibitor Atorvastatin

Wolfgang Jacobsen, Bernd Kuhn, Andrea Soldner, Gabriele Kirchner, Karl-Fr. Sewing, Peter A. Kollman, Leslie Z. Benet and Uwe Christians
Drug Metabolism and Disposition November 2000, 28 (11) 1369-1378;
Wolfgang Jacobsen
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Bernd Kuhn
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Andrea Soldner
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Gabriele Kirchner
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Karl-Fr. Sewing
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Peter A. Kollman
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Leslie Z. Benet
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Uwe Christians
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Article Information

vol. 28 no. 11 1369-1378
PubMed 
11038166

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 10, 2000
  • Accepted July 27, 2000
  • Published online November 1, 2000.

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Wolfgang Jacobsen1,
  2. Bernd Kuhn2,
  3. Andrea Soldner1,
  4. Gabriele Kirchner3,
  5. Karl-Fr. Sewing3,
  6. Peter A. Kollman2,
  7. Leslie Z. Benet1 and
  8. Uwe Christians1,3
  1. Departments of 1Biopharmaceutical Sciences (W.J., A.S., L.Z.B., U.C.), and 2Pharmaceutical Chemistry (B.K., P.A.K.), School of Pharmacy, University of California, San Francisco, California; and 3Institut für Pharmakologie, Medizinische Hochschule Hannover, Hannover, Germany (G.K., K.-F.S., U.C.)
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    Drug Metabolism and Disposition: 28 (11)
    Drug Metabolism and Disposition
    Vol. 28, Issue 11
    1 Nov 2000
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    Research ArticleArticle

    Lactonization Is the Critical First Step in the Disposition of the 3-Hydroxy-3-Methylglutaryl-Coa Reductase Inhibitor Atorvastatin

    Wolfgang Jacobsen, Bernd Kuhn, Andrea Soldner, Gabriele Kirchner, Karl-Fr. Sewing, Peter A. Kollman, Leslie Z. Benet and Uwe Christians
    Drug Metabolism and Disposition November 1, 2000, 28 (11) 1369-1378;

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    Research ArticleArticle

    Lactonization Is the Critical First Step in the Disposition of the 3-Hydroxy-3-Methylglutaryl-Coa Reductase Inhibitor Atorvastatin

    Wolfgang Jacobsen, Bernd Kuhn, Andrea Soldner, Gabriele Kirchner, Karl-Fr. Sewing, Peter A. Kollman, Leslie Z. Benet and Uwe Christians
    Drug Metabolism and Disposition November 1, 2000, 28 (11) 1369-1378;
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