Table of Contents

Articles

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  Involvement of Human Cytochrome P450 2D6 in the Bioactivation of Acetaminophen

  Haijun Dong, Robert L. Haining, Kenneth E. Thummel, Allan E. Rettie and Sidney D. Nelson

  Drug Metabolism and Disposition December 2000, 28 (12) 1397-1400;
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  Disposition of l-Carnitine and Its Short-Chain Esters, Acetyl-l-carnitine and Propionyl-l-carnitine, in the Rat Isolated Perfused Liver

  Angelo Mancinelli, Antonio Longo, Roger L. Nation and Allan M. Evans

  Drug Metabolism and Disposition December 2000, 28 (12) 1401-1404;
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  Very Slow Chiral Inversion of Clopidogrel in Rats: A Pharmacokinetic and Mechanistic Investigation

  Marianne Reist, Marieke Roy-de Vos, Jean-Pierre Montseny, Joachim M. Mayer, Pierre-Alain Carrupt, Yves Berger and Bernard Testa

  Drug Metabolism and Disposition December 2000, 28 (12) 1405-1410;
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  Comparative Tolerability, Pharmacodynamics, and Pharmacokinetics of a Metabolite of a Quinolizinone Hypnotic and Zolpidem in Healthy Subjects

  Jasper Dingemanse, Michele Bury, Yasmin Hussain and Paul van Giersbergen

  Drug Metabolism and Disposition December 2000, 28 (12) 1411-1416;
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  In Vitro Characterization of the Oxidative Cleavage of the Octyl Side Chain of Olanexidine, a Novel Antimicrobial Agent, in Dog Liver Microsomes

  Ken Umehara, Shoji Kudo, Yukihiro Hirao, Seiji Morita, Tadaaki Ohtani, Minoru Uchida and Gohachiro Miyamoto

  Drug Metabolism and Disposition December 2000, 28 (12) 1417-1424;
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  Pharmacogenetics of the ArylamineN-Acetyltransferases: A Symposium in Honor of Wendell W. Weber

  David W. Hein, Charlene A. McQueen, Denis M. Grant, Geoffrey H. Goodfellow, Fred F. Kadlubar and Wendell W. Weber

  Drug Metabolism and Disposition December 2000, 28 (12) 1425-1432;
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  Probenecid-Associated Alterations in Valproic Acid Pharmacokinetics in Rats: Can in Vivo Disposition of Valproate Glucuronide Be Predicted from in Vitro Formation Data?

  E. Stacy Ward, Gary M. Pollack and Kim L. R. Brouwer

  Drug Metabolism and Disposition December 2000, 28 (12) 1433-1439;
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  Substrate-Dependent Modulation of CYP3A4 Catalytic Activity: Analysis of 27 Test Compounds with Four Fluorometric Substrates

  David M. Stresser, Andrew P. Blanchard, Stephanie D. Turner, John C. L. Erve, Andre A. Dandeneau, Vaughn P. Miller and Charles L. Crespi

  Drug Metabolism and Disposition December 2000, 28 (12) 1440-1448;
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  Identification of the Human Liver Cytochrome P450 Isoenzyme Responsible for the 6-Methylhydroxylation of the Novel Anticancer Drug 5,6-Dimethylxanthenone-4-acetic Acid

  Shufeng Zhou, James W. Paxton, Malcolm D. Tingle and Philip Kestell

  Drug Metabolism and Disposition December 2000, 28 (12) 1449-1456;
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  Roles of Cytochromes P450 1A2, 2A6, and 2C8 in 5-Fluorouracil Formation from Tegafur, an Anticancer Prodrug, in Human Liver Microsomes

  Tomoko Komatsu, Hiroshi Yamazaki, Noriaki Shimada, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition December 2000, 28 (12) 1457-1463;
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  The Incorporation of Cocaine and Metabolites into Hair: Effects of Dose and Hair Pigmentation

  Deanna L. Hubbard, Diana G. Wilkins and Douglas E. Rollins

  Drug Metabolism and Disposition December 2000, 28 (12) 1464-1469;
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  Effect of Long-Term Ethanol Exposure on the Acinar Distribution of Hepatic Glutathione S-Transferase

  Tamara Vanhaecke, Kai O. Lindros, Teija Oinonen, Antoine Vercruysse and Vera Rogiers

  Drug Metabolism and Disposition December 2000, 28 (12) 1470-1474;
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  Characterization of Rat Liver Microsomal Metabolites of Clivorine, an Hepatotoxic Otonecine-Type Pyrrolizidine Alkaloid

  Ge Lin, Yan-Yan Cui and Edward M. Hawes

  Drug Metabolism and Disposition December 2000, 28 (12) 1475-1483;
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  Panipenum, A Carbapenem Antibiotic, Increases the Level of Hepatic Udp-Glucuronic Acid in Rats

  Naotoshi Yamamura, Kaoru Imura-Miyoshi and Hideo Naganuma

  Drug Metabolism and Disposition December 2000, 28 (12) 1484-1486;
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  Disposition and α₁-Adrenoceptor Binding Characteristics of JTH-601 and Its Metabolites in Rat Tissues

  Shizuo Yamada, Takashi Okura, Ryohei Kimura, Yoshiharu Deguchi, Yasunori Suzuki, Takuo Kobayashi and Kazuo Aisaka

  Drug Metabolism and Disposition December 2000, 28 (12) 1487-1492;
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  Comparison between Cytochrome P450 (CYP) Content and Relative Activity Approaches to Scaling from cDNA-Expressed CYPs to Human Liver Microsomes: Ratios of Accessory Proteins as Sources of Discrepancies between the Approaches

  Karthik Venkatakrishnan, Lisa L. von Moltke, Michael H. Court, Jerold S. Harmatz, Charles L. Crespi and David J. Greenblatt

  Drug Metabolism and Disposition December 2000, 28 (12) 1493-1504;
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  Biotransformation of the Anti-Angiogenic Compound SU5416

  Lida Antonian, Hongbing Zhang, Cheng Yang, Greg Wagner, Laura K. Shawver, Manjunath Shet, Brian Ogilvie, Ajay Madan and Andrew Parkinson

  Drug Metabolism and Disposition December 2000, 28 (12) 1505-1512;
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  Chemoenzymatic Preparation of Silybin β-Glucuronides and Their Biological Evaluation

  Vladimír Kr̆en, Jitka Ulrichová, Pavel Kosina, David Stevenson, Petr Sedmera, Věra Přikrylová, Petr Halada and Vilím šsimánek

  Drug Metabolism and Disposition December 2000, 28 (12) 1513-1517;
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  A Convenient In Vitro Screening Method for Predicting In Vivo Drug Metabolic Clearance Using Isolated Hepatocytes Suspended in Serum

  Yoshihiro Shibata, Hiroyuki Takahashi and Yasuyuki Ishii

  Drug Metabolism and Disposition December 2000, 28 (12) 1518-1523;
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  Influence of N-Substitution of 7-Methoxy-4-(aminomethyl)-coumarin on Cytochrome P450 Metabolism and Selectivity

  Jennifer Venhorst, Rob C. A. Onderwater, John H. N. Meerman, Jan N. M. Commandeur and Nico P. E. Vermeulen

  Drug Metabolism and Disposition December 2000, 28 (12) 1524-1532;