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Drug Metabolism & Disposition

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Table of Contents

December 01, 2000; Volume 28,Issue 12

Short Communications

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    Effects of Macrolide Antibiotics on CYP3A Expression in Human and Rat Hepatocytes: Interspecies Differences in Response to Troleandomycin
    Nathalie Ledirac, Georges de Sousa, Franck Fontaine, Constantin Agouridas, Jean Gugenheim, Giocando Lorenzon and Roger Rahmani
    Drug Metabolism and Disposition December 2000, 28 (12) 1391-1393;
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    Increased Absorption of the Antiviral Ester Prodrug Tenofovir Disoproxil in Rat Ileum by Inhibiting Its Intestinal Metabolism
    Jan Van Gelder, Sven Deferme, Pieter Annaert, Lieve Naesens, Erik De Clercq, Guy Van den Mooter, Renaat Kinget and Parick Augustijns
    Drug Metabolism and Disposition December 2000, 28 (12) 1394-1396;

Articles

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    Involvement of Human Cytochrome P450 2D6 in the Bioactivation of Acetaminophen
    Haijun Dong, Robert L. Haining, Kenneth E. Thummel, Allan E. Rettie and Sidney D. Nelson
    Drug Metabolism and Disposition December 2000, 28 (12) 1397-1400;
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    Disposition of l-Carnitine and Its Short-Chain Esters, Acetyl-l-carnitine and Propionyl-l-carnitine, in the Rat Isolated Perfused Liver
    Angelo Mancinelli, Antonio Longo, Roger L. Nation and Allan M. Evans
    Drug Metabolism and Disposition December 2000, 28 (12) 1401-1404;
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    Very Slow Chiral Inversion of Clopidogrel in Rats: A Pharmacokinetic and Mechanistic Investigation
    Marianne Reist, Marieke Roy-de Vos, Jean-Pierre Montseny, Joachim M. Mayer, Pierre-Alain Carrupt, Yves Berger and Bernard Testa
    Drug Metabolism and Disposition December 2000, 28 (12) 1405-1410;
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    Comparative Tolerability, Pharmacodynamics, and Pharmacokinetics of a Metabolite of a Quinolizinone Hypnotic and Zolpidem in Healthy Subjects
    Jasper Dingemanse, Michele Bury, Yasmin Hussain and Paul van Giersbergen
    Drug Metabolism and Disposition December 2000, 28 (12) 1411-1416;
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    In Vitro Characterization of the Oxidative Cleavage of the Octyl Side Chain of Olanexidine, a Novel Antimicrobial Agent, in Dog Liver Microsomes
    Ken Umehara, Shoji Kudo, Yukihiro Hirao, Seiji Morita, Tadaaki Ohtani, Minoru Uchida and Gohachiro Miyamoto
    Drug Metabolism and Disposition December 2000, 28 (12) 1417-1424;
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    Pharmacogenetics of the ArylamineN-Acetyltransferases: A Symposium in Honor of Wendell W. Weber
    David W. Hein, Charlene A. McQueen, Denis M. Grant, Geoffrey H. Goodfellow, Fred F. Kadlubar and Wendell W. Weber
    Drug Metabolism and Disposition December 2000, 28 (12) 1425-1432;
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    Probenecid-Associated Alterations in Valproic Acid Pharmacokinetics in Rats: Can in Vivo Disposition of Valproate Glucuronide Be Predicted from in Vitro Formation Data?
    E. Stacy Ward, Gary M. Pollack and Kim L. R. Brouwer
    Drug Metabolism and Disposition December 2000, 28 (12) 1433-1439;
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    Substrate-Dependent Modulation of CYP3A4 Catalytic Activity: Analysis of 27 Test Compounds with Four Fluorometric Substrates
    David M. Stresser, Andrew P. Blanchard, Stephanie D. Turner, John C. L. Erve, Andre A. Dandeneau, Vaughn P. Miller and Charles L. Crespi
    Drug Metabolism and Disposition December 2000, 28 (12) 1440-1448;
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    Identification of the Human Liver Cytochrome P450 Isoenzyme Responsible for the 6-Methylhydroxylation of the Novel Anticancer Drug 5,6-Dimethylxanthenone-4-acetic Acid
    Shufeng Zhou, James W. Paxton, Malcolm D. Tingle and Philip Kestell
    Drug Metabolism and Disposition December 2000, 28 (12) 1449-1456;
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    Roles of Cytochromes P450 1A2, 2A6, and 2C8 in 5-Fluorouracil Formation from Tegafur, an Anticancer Prodrug, in Human Liver Microsomes
    Tomoko Komatsu, Hiroshi Yamazaki, Noriaki Shimada, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition December 2000, 28 (12) 1457-1463;
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    The Incorporation of Cocaine and Metabolites into Hair: Effects of Dose and Hair Pigmentation
    Deanna L. Hubbard, Diana G. Wilkins and Douglas E. Rollins
    Drug Metabolism and Disposition December 2000, 28 (12) 1464-1469;
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    Effect of Long-Term Ethanol Exposure on the Acinar Distribution of Hepatic Glutathione S-Transferase
    Tamara Vanhaecke, Kai O. Lindros, Teija Oinonen, Antoine Vercruysse and Vera Rogiers
    Drug Metabolism and Disposition December 2000, 28 (12) 1470-1474;
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    Characterization of Rat Liver Microsomal Metabolites of Clivorine, an Hepatotoxic Otonecine-Type Pyrrolizidine Alkaloid
    Ge Lin, Yan-Yan Cui and Edward M. Hawes
    Drug Metabolism and Disposition December 2000, 28 (12) 1475-1483;
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    Panipenum, A Carbapenem Antibiotic, Increases the Level of Hepatic Udp-Glucuronic Acid in Rats
    Naotoshi Yamamura, Kaoru Imura-Miyoshi and Hideo Naganuma
    Drug Metabolism and Disposition December 2000, 28 (12) 1484-1486;
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    Disposition and α1-Adrenoceptor Binding Characteristics of JTH-601 and Its Metabolites in Rat Tissues
    Shizuo Yamada, Takashi Okura, Ryohei Kimura, Yoshiharu Deguchi, Yasunori Suzuki, Takuo Kobayashi and Kazuo Aisaka
    Drug Metabolism and Disposition December 2000, 28 (12) 1487-1492;
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    Comparison between Cytochrome P450 (CYP) Content and Relative Activity Approaches to Scaling from cDNA-Expressed CYPs to Human Liver Microsomes: Ratios of Accessory Proteins as Sources of Discrepancies between the Approaches
    Karthik Venkatakrishnan, Lisa L. von Moltke, Michael H. Court, Jerold S. Harmatz, Charles L. Crespi and David J. Greenblatt
    Drug Metabolism and Disposition December 2000, 28 (12) 1493-1504;
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    Biotransformation of the Anti-Angiogenic Compound SU5416
    Lida Antonian, Hongbing Zhang, Cheng Yang, Greg Wagner, Laura K. Shawver, Manjunath Shet, Brian Ogilvie, Ajay Madan and Andrew Parkinson
    Drug Metabolism and Disposition December 2000, 28 (12) 1505-1512;
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    Chemoenzymatic Preparation of Silybin β-Glucuronides and Their Biological Evaluation
    Vladimír Kr̆en, Jitka Ulrichová, Pavel Kosina, David Stevenson, Petr Sedmera, Věra Přikrylová, Petr Halada and Vilím šsimánek
    Drug Metabolism and Disposition December 2000, 28 (12) 1513-1517;
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    A Convenient In Vitro Screening Method for Predicting In Vivo Drug Metabolic Clearance Using Isolated Hepatocytes Suspended in Serum
    Yoshihiro Shibata, Hiroyuki Takahashi and Yasuyuki Ishii
    Drug Metabolism and Disposition December 2000, 28 (12) 1518-1523;
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    Influence of N-Substitution of 7-Methoxy-4-(aminomethyl)-coumarin on Cytochrome P450 Metabolism and Selectivity
    Jennifer Venhorst, Rob C. A. Onderwater, John H. N. Meerman, Jan N. M. Commandeur and Nico P. E. Vermeulen
    Drug Metabolism and Disposition December 2000, 28 (12) 1524-1532;
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Drug Metabolism and Disposition: 28 (12)
Drug Metabolism and Disposition
Vol. 28, Issue 12
1 Dec 2000
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