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Drug Metabolism & Disposition

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Table of Contents

February 01, 2000; Volume 28,Issue 2

Short Communications

  • You have access
    Robust Assessment of Statistical Significance in the Use of Unbound/Intrinsic Pharmacokinetic Parameters in Quantitative Structure–Pharmacokinetic Relationships with Lipophilicity
    Andrew M. Davis, Peter J. H. Webborn and David W. Salt
    Drug Metabolism and Disposition February 2000, 28 (2) 103-106;
  • You have access
    Extensive Metabolism of Diltiazem and P-Glycoprotein-Mediated Efflux of Desacetyl-Diltiazem (M1) by Rat Jejunum In Vitro
    Espen Molden, Hege Christensen and Reidar Bredo Sund
    Drug Metabolism and Disposition February 2000, 28 (2) 107-109;
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    Novel Metabolic Pathway of Estrone and 17β-Estradiol Catalyzed by Cytochrome P-450
    Tomoyuki Ohe, Masaaki Hirobe and Tadahiko Mashino
    Drug Metabolism and Disposition February 2000, 28 (2) 110-112;
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    Histologic Localization of Serum Constituents,45Ca2+, 36Cl−, [14C]Urea, and [35S]Cysteine in Forming Hair after Systemic Administration
    Peter R. Stout and James A. Ruth
    Drug Metabolism and Disposition February 2000, 28 (2) 113-117;

Accelerated Communication

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    Identification of a Ubiquitination-Target/Substrate-Interaction Domain of Cytochrome P-450 (CYP) 2E1
    Amit Banerjee, Thomas A. Kocarek and Raymond F. Novak
    Drug Metabolism and Disposition February 2000, 28 (2) 118-124;

Articles

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    Drug Interactions with Calcium Channel Blockers: Possible Involvement of Metabolite-Intermediate Complexation with CYP3A
    Bennett Ma, Thomayant Prueksaritanont and Jiunn H. Lin
    Drug Metabolism and Disposition February 2000, 28 (2) 125-130;
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    Antisense Oligonucleotides Targeted to thep53 Gene Modulate Liver Regeneration In Vivo
    Vikram Arora and Patrick L. Iversen
    Drug Metabolism and Disposition February 2000, 28 (2) 131-138;
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    Tissue- and Gender-Specific Expression ofN-Acetyltransferase 2 (Nat2*) during Development of the Outbred Mouse Strain CD-1
    Lourdes Estrada, Kimon C. Kanelakis, Gerald N. Levy and Wendell W. Weber
    Drug Metabolism and Disposition February 2000, 28 (2) 139-146;
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    Metabolism and Pharmacokinetics, in the Rat, of (R)-N-(2-Heptyl)Methyl-Propargylamine (R-2HMP), A New Potent Monoamine Oxidase Inhibitor and Antiapoptotic Agent
    David A. Durden, Lillian E. Dyck, Bruce A. Davis, Ya-Dong Liu and Alan A. Boulton
    Drug Metabolism and Disposition February 2000, 28 (2) 147-154;
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    Pharmacokinetics of the Rapid-Acting Insulin Analog, Insulin Aspart, in Rats, Dogs, and Pigs, and Pharmacodynamics of Insulin Aspart in Pigs
    Anne Plum, Henrik Agersø and Lennart Andersen
    Drug Metabolism and Disposition February 2000, 28 (2) 155-160;
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    Prediction of Pharmacokinetic Drug/Drug Interactions from In Vitro Data: Interactions of the Nonsteroidal Anti-Inflammatory Drug Lornoxicam with Oral Anticoagulants
    Christopher Kohl and Michael Steinkellner
    Drug Metabolism and Disposition February 2000, 28 (2) 161-168;
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    Population-Specific Polymorphisms of the HumanFMO3 Gene: Significance for Detoxication
    John R. Cashman, Beverly R. Akerman, Susan M. Forrest and Eileen P. Treacy
    Drug Metabolism and Disposition February 2000, 28 (2) 169-173;
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    Molecular Dynamics Simulation of Metallothionein-Drug Complexes
    Zoltán Szilágyi and Catherine Fenselau
    Drug Metabolism and Disposition February 2000, 28 (2) 174-179;
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    Metabolism of 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in Primary Cultures of Rat Alveolar Type II Cells
    Eberhard Schrader, Karen I. Hirsch-Ernst, Ekkehard Scholz, Georg F. Kahl and Heidi Foth
    Drug Metabolism and Disposition February 2000, 28 (2) 180-185;
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    Dexamethasone Differentially Regulates Expression of Carboxylesterase Genes in Humans and Rats
    Weizhu Zhu, Li Song, He Zhang, Lynn Matoney, Edward LeCluyse and Bingfang Yan
    Drug Metabolism and Disposition February 2000, 28 (2) 186-191;
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    Disposition of Radioactivity in Fischer 344 Rats after Single and Multiple Inhalation Exposure to [14C]Octamethylcyclotetrasiloxane ([14C]D4)
    Kathleen P. Plotzke, Steven D. Crofoot, Eckhardt S. Ferdinandi, J. Gregory Beattie, Richard H. Reitz, Debra A. McNett and Robert G. Meeks
    Drug Metabolism and Disposition February 2000, 28 (2) 192-204;
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    Pharmacokinetics of All-trans Retinoic Acid, 13-cis Retinoic Acid, and Fenretinide in Plasma and Brain of Rat
    François Le Doze, Daniele Debruyne, Françoise Albessard, Louisa Barre and Gilles Louis Defer
    Drug Metabolism and Disposition February 2000, 28 (2) 205-208;
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    Biliary Metabolites of β-Artemether in Rats: Biotransformations of an Antimalarial Endoperoxide
    James L. Maggs, Laurence P. D. Bishop, Geoffrey Edwards, Paul M. O'Neill, Stephen A. Ward, Peter A. Winstanley and B. Kevin Park
    Drug Metabolism and Disposition February 2000, 28 (2) 209-217;
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    o-Hydroxyphenylacetaldehyde Is a Hepatotoxic Metabolite of Coumarin
    Stephanie L. Born, Joanna K. Hu and Lois D. Lehman-McKeeman
    Drug Metabolism and Disposition February 2000, 28 (2) 218-223;
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    A New Physiologically Based, Segregated-Flow Model to Explain Route-Dependent Intestinal Metabolism
    Diem Cong, Margaret Doherty and K. Sandy Pang
    Drug Metabolism and Disposition February 2000, 28 (2) 224-235;
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    Systemic Coadministration of Chloramphenicol with Intravenous but not Intracerebroventricular Morphine Markedly Increases Morphine Antinociception and Delays Development of Antinociceptive Tolerance in Rats
    Maree T. Smith, Carsten K. Nielsen, Megan Y. C. Lim-Fraser, Andrew W. E. Wright and Michael Lau
    Drug Metabolism and Disposition February 2000, 28 (2) 236-244;
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In this issue

Drug Metabolism and Disposition: 28 (2)
Drug Metabolism and Disposition
Vol. 28, Issue 2
1 Feb 2000
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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