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Drug Metabolism & Disposition

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Table of Contents

March 01, 2000; Volume 28,Issue 3

Editorial

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    Editorial
    James R. Halpert
    Drug Metabolism and Disposition March 2000, 28 (3) 245;

Review

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    In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
    J. Brian Houston and Kathryn E. Kenworthy
    Drug Metabolism and Disposition March 2000, 28 (3) 246-254;

Articles

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    Bioactivation and Covalent Binding of Hydroxyfluperlapine in Human Neutrophils: Implications for Fluperlapine-Induced Agranulocytosis
    W. George Lai, Iain Gardner, Nasir Zahid and Jack P. Uetrecht
    Drug Metabolism and Disposition March 2000, 28 (3) 255-263;
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    The Role of mdr1a P-Glycoprotein in the Biliary and Intestinal Secretion of Doxorubicin and Vinblastine in Mice
    Judith van Asperen, Olaf van Tellingen and Jos H. Beijnen
    Drug Metabolism and Disposition March 2000, 28 (3) 264-267;
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    The Glucocorticoid Receptor Is Essential for Induction of Cytochrome P-4502B by Steroids but Not for Drug or Steroid Induction of CYP3A or P-450 Reductase in Mouse Liver
    Erin G. Schuetz, Wolfgang Schmid, Gunther Schutz, Cynthia Brimer, Kazuto Yasuda, Tetsuya Kamataki, Lester Bornheim, Kathy Myles and Timothy J. Cole
    Drug Metabolism and Disposition March 2000, 28 (3) 268-278;
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    Diphenhydramine Disposition in the Sheep Maternal-Placental-Fetal Unit: Gestational Age, Plasma Drug Protein Binding, and Umbilical Blood Flow Effects on Clearance
    Sanjeev Kumar, George R. Tonn, K. Wayne Riggs and Dan W. Rurak
    Drug Metabolism and Disposition March 2000, 28 (3) 279-285;
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    Incorporation and Retention of RadiolabeledS-(+)-and R-(−)-Methamphetamine andS(+)- andR(−)-N-(n-butyl)-amphetamine in Mouse Hair after Systemic Administration
    Peter R. Stout, David J. Claffey and James A. Ruth
    Drug Metabolism and Disposition March 2000, 28 (3) 286-291;
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    Human Cytochrome P-450 Metabolism of Retinals to Retinoic Acids
    Qing-Yu Zhang, Deborah Dunbar and Laurence Kaminsky
    Drug Metabolism and Disposition March 2000, 28 (3) 292-297;
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    Analysis of Soy Isoflavone Conjugation In Vitro and in Human Blood Using Liquid Chromatography-Mass Spectrometry
    Daniel R. Doerge, Hebron C. Chang, Mona I. Churchwell and C. Lee Holder
    Drug Metabolism and Disposition March 2000, 28 (3) 298-307;
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    Metabolism and Excretion of [14C]Celecoxib in Healthy Male Volunteers
    Susan K. Paulson, Jeremy D. Hribar, Norman W. K. Liu, Elisabeth Hajdu, Roy H. Bible, Antoni Piergies and Aziz Karim
    Drug Metabolism and Disposition March 2000, 28 (3) 308-314;
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    Biosynthesis Of All-trans-Retinoic Acid from All-trans-Retinol: Catalysis of All-trans-Retinol Oxidation by Human P-450 Cytochromes
    Hao Chen, William N. Howald and Mont R. Juchau
    Drug Metabolism and Disposition March 2000, 28 (3) 315-322;
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    Input Rate as a Major Determinant of Furosemide Pharmacodynamics: Influence of Fluid Replacement and Hypoalbuminemia
    Gilberto Castañeda-Hernández, Josep Vergés, Vincent Pichette, Lucie Héroux, Gilles Caillé and Patrick du Souich
    Drug Metabolism and Disposition March 2000, 28 (3) 323-328;
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    Interactions of HIV Protease Inhibitors with a Human Organic Cation Transporter in a Mammalian Expression System
    Lei Zhang, Wenche Gorset, Carla B. Washington, Terrence F. Blaschke, Deanna L. Kroetz and Kathleen M. Giacomini
    Drug Metabolism and Disposition March 2000, 28 (3) 329-334;
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    m-Hydroxy Benzoylecgonine Recovery in Fetal Guinea Pigs
    Lynn M. Iwamoto, Christine M. Moore, Naomi Fujiwara, Michael J. Christ, Delores M. Gries and Kenneth T. Nakamura
    Drug Metabolism and Disposition March 2000, 28 (3) 335-338;
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    On the Metabolism of the Amphetamine-Derived Antispasmodic Drug Mebeverine: Gas Chromatography-Mass Spectrometry Studies on Rat Liver Microsomes and on Human Urine
    Thomas Kraemer, Joerg Bickeboeller-Friedrich and Hans H. Maurer
    Drug Metabolism and Disposition March 2000, 28 (3) 339-347;
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    Selective Involvement of Cytochrome P450 2D Subfamily in In Vivo 4-Hydroxylation of Amphetamine in Rat
    Michael Y. L. Law, Matthew H. Slawson and David E. Moody
    Drug Metabolism and Disposition March 2000, 28 (3) 348-353;
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    CYP2C19 Participates in Tolbutamide Hydroxylation by Human Liver Microsomes
    Michael R. Wester, Jerome M. Lasker, Eric F. Johnson and Judy L. Raucy
    Drug Metabolism and Disposition March 2000, 28 (3) 354-359;
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    Human Cytochrome P-450 3A4: In Vitro Drug-Drug Interaction Patterns Are Substrate-Dependent
    Regina W. Wang, Deborah J. Newton, Nini Liu, William M. Atkins and Anthony Y. H. Lu
    Drug Metabolism and Disposition March 2000, 28 (3) 360-366;
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    Butyrylcholinesterase Accelerates Cocaine Metabolism: In Vitro and In Vivo Effects in Nonhuman Primates and Humans
    Gilberto N. Carmona, Rebecca A. Jufer, Steven R. Goldberg, David A. Gorelick, Nigel H. Greig, Qian-Sheng Yu, Edward J. Cone and Charles W. Schindler
    Drug Metabolism and Disposition March 2000, 28 (3) 367-371;
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In this issue

Drug Metabolism and Disposition: 28 (3)
Drug Metabolism and Disposition
Vol. 28, Issue 3
1 Mar 2000
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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