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Drug Metabolism & Disposition

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Table of Contents

April 01, 2000; Volume 28,Issue 4

Short Communications

  • You have access
    N-Methylprotoporphyrin Is a More Potent Inhibitor of Recombinant Human Than of Recombinant Chicken Ferrochelatase
    Jeremy T. Gamble, Harry A. Dailey and Gerald S. Marks
    Drug Metabolism and Disposition April 2000, 28 (4) 373-375;
  • You have access
    Species Differences in The Regio- and Stereoselectivity of 1-Nitronaphthalene Metabolism
    Katherine C. Watt and Alan R. Buckpitt
    Drug Metabolism and Disposition April 2000, 28 (4) 376-378;
  • You have access
    Human Cytochrome P450 Maximal Activities In Pediatric versus Adult Liver
    Javier G. Blanco, Patricia L. Harrison, William E. Evans and Mary V. Relling
    Drug Metabolism and Disposition April 2000, 28 (4) 379-382;
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    Oxidative Metabolism of Bupivacaine into Pipecolylxylidine in Humans Is Mainly Catalyzed by CYP3A
    Manon Gantenbein, Laurence Attolini, Bernard Bruguerolle, Pierre-Henri Villard, Franck Puyoou, Alain Durand, Bruno Lacarelle, Jean Hardwigsen and Yves-Patrice Le-Treut
    Drug Metabolism and Disposition April 2000, 28 (4) 383-385;

Articles

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    Pharmacokinetics of a Model Organic Nitrite Inhalant and its Alcohol Metabolite in Rats
    William Kielbasa and Ho-Leung Fung
    Drug Metabolism and Disposition April 2000, 28 (4) 386-391;
  • You have access
    In Vitro Biotransformation of Sildenafil (Viagra): Identification of Human Cytochromes and Potential Drug Interactions
    Jill S. Warrington, Richard I. Shader, Lisa L. von Moltke and David J. Greenblatt
    Drug Metabolism and Disposition April 2000, 28 (4) 392-397;
  • You have access
    Thioesterification of 2-Arylpropionic Acids by Recombinant Acyl-Coenzyme A Synthetases (ACS1 and ACS2)
    Cendrine Sevoz, Etienne Benoit and Thierry Buronfosse
    Drug Metabolism and Disposition April 2000, 28 (4) 398-402;
  • You have access
    Pharmacokinetics, Biliary Excretion, and Tissue Distribution of Novel Anti-HIV Agents, Cosalane and Dihydrocosalane, in Sprague-Dawley Rats
    Kameswara R. Kuchimanchi, Chandrasekhar Udata, Thomas P. Johnston and Ashim K. Mitra
    Drug Metabolism and Disposition April 2000, 28 (4) 403-408;
  • You have access
    Studies on the Cytochrome P450 (CYP)-Mediated Metabolic Properties of Miocamycin: Evaluation of the Possibility of a Metabolic Intermediate Complex Formation with CYP, and Identification of the Human CYP Isoforms
    Mie Kasahara, Hisashi Suzuki and Izumi Komiya
    Drug Metabolism and Disposition April 2000, 28 (4) 409-417;
  • You have access
    Disposition in Rats of N-Pyridinium-propyl-cyclam,N-Triethylammonium-propyl-cyclam, andN-[Triethylammonium]-3-propyl-[15]ane-N5, Potential Cartilage Imaging Agents
    Jean-Claude Maurizis, Maryse Rapp, Colette Nicolas, Monique Ollier, Michel Verny and Jean-Claude Madelmont
    Drug Metabolism and Disposition April 2000, 28 (4) 418-422;
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    Pharmacokinetics, Metabolism, and Excretion of Irinotecan (CPT-11) Following I.V. Infusion of [14C]CPT-11 in Cancer Patients
    John Greg Slatter, Larry J. Schaaf, James P. Sams, Kenneth L. Feenstra, Mark G. Johnson, Paul A. Bombardt, Karen Sue Cathcart, Michael T. Verburg, Laura K. Pearson, Linda D. Compton, Langdon L. Miller, David S. Baker, Caroline V. Pesheck and Raymond S. Lord
    Drug Metabolism and Disposition April 2000, 28 (4) 423-433;
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    The Synthesis, In Vitro Reactivity, and Evidence for Formation in Humans of 5-Phenyl-1,3-oxazinane-2,4-dione, a Metabolite of Felbamate
    Charles D. Thompson, Thomas A. Miller, Mary T. Barthen, Christine M. Dieckhaus, R. Duane Sofia and Timothy L. Macdonald
    Drug Metabolism and Disposition April 2000, 28 (4) 434-439;
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    Porcine Kidney Microsomal Cysteine S-ConjugateN-Acetyltransferase-CatalyzedN-Acetylation of Haloalkene-Derived CysteineS-Conjugates
    Torsten Kraus, Viuita Uttamsingh, M.W. Anders and Sabine Wolf
    Drug Metabolism and Disposition April 2000, 28 (4) 440-445;
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    Metabolism and Disposition of Moxonidine in Fischer 344 Rats
    Minxia M. He, Trent L. Abraham, Thomas J. Lindsay, Sylvia H. Chay, Boris A. Czeskis and Lisa A. Shipley
    Drug Metabolism and Disposition April 2000, 28 (4) 446-459;
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    Route-Dependent Nonlinear Pharmacokinetics of a Novel HIV Protease Inhibitor: Involvement of Enzyme Inactivation
    Jiunn H. Lin, I-Wu Chen, Masato Chiba, Joy A. Nishime and Florencia A. deLuna
    Drug Metabolism and Disposition April 2000, 28 (4) 460-466;
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    Prediction of In Vivo Drug-Drug Interactions Based on Mechanism-based Inhibition from In Vitro Data: Inhibition of 5-Fluorouracil Metabolism by (E)-5-(2-Bromovinyl)uracil
    Shin-ichi Kanamitsu, Kiyomi Ito, Haruhiro Okuda, Kenichiro Ogura, Tadashi Watabe, Kei Muro and Yuichi Sugiyama
    Drug Metabolism and Disposition April 2000, 28 (4) 467-474;
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    Prediction of in Vivo Drug-Drug Interactions between Tolbutamide and Various Sulfonamides in Humans Based on in Vitro Experiments
    Kanji Komatsu, Kiyomi Ito, Yukiko Nakajima, Shin-ichi Kanamitsu, Susumu Imaoka, Yoshihiko Funae, Carol E. Green, Charles A. Tyson, Noriaki Shimada and Yuichi Sugiyama
    Drug Metabolism and Disposition April 2000, 28 (4) 475-481;
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    Effects of Long-Term Grapefruit Juice Ingestion on Nifedipine Pharmacokinetics: Induction of Rat Hepatic P-450 by Grapefruit Juice
    Kiminori Mohri, Yoshihiro Uesawa and Ken-ichi Sagawa
    Drug Metabolism and Disposition April 2000, 28 (4) 482-486;
  • You have access
    The N-Acetylation of Arsanilic Acid In Vitro by Mammalian Enzymes
    Gladys S. Bayse, Laide A. Jinadu, Kiana L. Shaw and Kelita L. Wiley
    Drug Metabolism and Disposition April 2000, 28 (4) 487-492;
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Drug Metabolism and Disposition: 28 (4)
Drug Metabolism and Disposition
Vol. 28, Issue 4
1 Apr 2000
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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