Drug Metabolism and Disposition: 28 (6)

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Effect of P-gp inhibitors (dose shown is per kilogram of body weight) on brain/plasma and testes/plasma distribution ratios of [¹⁴C]nelfinavir in wild-type mdr1a(+/+) and mdr1a(/) mice. See the article by Choo et al. on page 655 of this issue.

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Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUC_I/AUC) RATIOS
THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model

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