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Drug Metabolism & Disposition

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Table of Contents

August 01, 2000; Volume 28,Issue 8

Short Communications

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    CYP2C8/9 Mediate Dapsone N-Hydroxylation at Clinical Concentrations of Dapsone
    Helen R. Winter, Yi Wang and Jashvant D. Unadkat
    Drug Metabolism and Disposition August 2000, 28 (8) 865-868;
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    Comparative N-Glucuronidation Kinetics of Ketotifen and Amitriptyline by Expressed Human UDP-Glucuronosyltransferases and Liver Microsomes
    Ursula Breyer-Pfaff, Udo Mey, Mitchell D. Green and Thomas R. Tephly
    Drug Metabolism and Disposition August 2000, 28 (8) 869-872;

Articles

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    Biliary and Urinary Metabolic Profiles of 1,2-Diethyl-3-hydroxypyridin-4-one (CP94) in the Rat
    Shu L. Lu, Itsaraet Gosriwatana, Ding Y. Liu, Zu D. Liu, Anthony I. Mallet and Robert C. Hider
    Drug Metabolism and Disposition August 2000, 28 (8) 873-879;
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    Metabolism of para-Aminophenol by Rat Hepatocytes
    Zimeng Yan, John G. Nikelly, Lewis Killmer and Joan B. Tarloff
    Drug Metabolism and Disposition August 2000, 28 (8) 880-886;
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    Oxidative Cleavage of the Octyl Side Chain of 1-(3,4-Dichlorobenzyl)-5-Octylbiguanide (OPB-2045) in Rat and Dog Liver Preparations
    Ken Umehara, Shoji Kudo, Yukihiro Hirao, Seiji Morita, Minoru Uchida, Masaaki Odomi and Gohachiro Miyamoto
    Drug Metabolism and Disposition August 2000, 28 (8) 887-894;
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    Mibefradil Is a P-Glycoprotein Substrate and a Potent Inhibitor of Both P-Glycoprotein and CYP3A In Vitro
    Christoph Wandel, Richard B. Kim, F. Peter Guengerich and Alastair J. J. Wood
    Drug Metabolism and Disposition August 2000, 28 (8) 895-898;
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    Isolation and Identification of Urinary Metabolites of Porfiromycin in Dogs and Humans
    Wensheng Lang, John Mao, Terrence W. Doyle and Bijan Almassian
    Drug Metabolism and Disposition August 2000, 28 (8) 899-904;
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    Mechanism-Based Inactivation of Cytochromes P450 2B1 and P450 2B6 by 2-Phenyl-2-(1-piperidinyl)propane
    Jarin Chun, Ute M. Kent, Rachel M. Moss, Lawrence M. Sayre and Paul F. Hollenberg
    Drug Metabolism and Disposition August 2000, 28 (8) 905-911;
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    Ontogeny of Valproic Acid Disposition and Metabolism: A Developmental Study in Postnatal Lambs and Adult Sheep
    Harvey Wong, Sanjeev Kumar, Dan W. Rurak, Eddie Kwan, Frank S. Abbott and K. Wayne Riggs
    Drug Metabolism and Disposition August 2000, 28 (8) 912-919;
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    Assessment of the Metabolic Chiral Inversion ofd-Leucine in Rat by Gas Chromatography-Mass Spectrometry Combined with a Stable Isotope Dilution Analysis
    Hiroshi Hasegawa, Takehisa Matsukawa, Yoshihiko Shinohara and Takao Hashimoto
    Drug Metabolism and Disposition August 2000, 28 (8) 920-924;
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    Pharmacokinetic Profiles in Rats After Intravenous, Oral, or Dermal Administration of Dapsone
    David R. Helton, David W. Osborne, Sharon K. Pierson, Michael H. Buonarati and Robert A. Bethem
    Drug Metabolism and Disposition August 2000, 28 (8) 925-929;
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    Concurrent Flavin-Containing Monooxygenase Down-Regulation and Cytochrome P-450 Induction by Dietary Indoles in Rat: Implications for Drug-Drug Interaction
    Sirinmas Katchamart, David M. Stresser, Shangara S. Dehal, David Kupfer and David E. Williams
    Drug Metabolism and Disposition August 2000, 28 (8) 930-936;
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    Identification of CYP3A4 as the Enzyme Involved in the Mono-N-Dealkylation of Disopyramide Enantiomers in Humans
    Hirotoshi Echizen, Michika Tanizaki, Jun Tatsuno, Kan Chiba, Teresa Berwick, Masayoshi Tani, Frank J. Gonzalez and Takashi Ishizaki
    Drug Metabolism and Disposition August 2000, 28 (8) 937-944;
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    Phenytoin Metabolism by Human Cytochrome P450: Involvement of P450 3A and 2C Forms in Secondary Metabolism and Drug-Protein Adduct Formation
    Leila Cuttle, Andrew J. Munns, Nicole A. Hogg, Justin R. Scott, Wayne D. Hooper, Ronald G. Dickinson and Elizabeth M. J. Gillam
    Drug Metabolism and Disposition August 2000, 28 (8) 945-950;
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    Glutathione S-Transferase Metabolism of the Antineoplastic Pentafluorophenylsulfonamide in Tissue Culture and Mice
    Walter P. Frankmoelle, Julio C. Medina, Bei Shan, Mathew R. Narbut and Holger Beckmann
    Drug Metabolism and Disposition August 2000, 28 (8) 951-958;
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    Involvement of CYP1A2 and CYP3A4 in LidocaineN-Deethylation and 3-Hydroxylation in Humans
    Jun-Sheng Wang, Janne T. Backman, Päivi Taavitsainen, Pertti J. Neuvonen and Kari T. Kivistö
    Drug Metabolism and Disposition August 2000, 28 (8) 959-965;
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    Stereoselective Metabolism of Omeprazole by Human Cytochrome P450 Enzymes
    Angela Äbelö, Tommy B. Andersson, Madeleine Antonsson, Anna Knuts Naudot, Inger Skånberg and Lars Weidolf
    Drug Metabolism and Disposition August 2000, 28 (8) 966-972;
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    Disposition of Radiolabeled Ifetroban in Rats, Dogs, Monkeys, and Humans
    Randy C. Dockens, Kenneth S. Santone, James G. Mitroka, Richard A. Morrison, Mohammed Jemal, Douglas S. Greene and Rashmi H. Barbhaiya
    Drug Metabolism and Disposition August 2000, 28 (8) 973-980;
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    Cloning of Canine Cytochrome P450 2E1 cDNA: Identification and Characterization of Two Variant Alleles
    Susan M. Lankford, Stephen A. Bai and Joyce A. Goldstein
    Drug Metabolism and Disposition August 2000, 28 (8) 981-986;
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    Detection of Cytochrome P450 and Other Drug-Metabolizing Enzyme mRNAs in Peripheral Blood Mononuclear Cells Using DNA Arrays
    Linh T. Nguyen, Murali Ramanathan, Bianca Weinstock-Guttman, Kiran Dole, Colleen Miller, Margaret Planter, Kara Patrick, Carol Brownscheidle and Lawrence D. Jacobs
    Drug Metabolism and Disposition August 2000, 28 (8) 987-993;
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    Three- and Four-Dimensional-Quantitative Structure Activity Relationship (3D/4D-QSAR) Analyses of CYP2C9 Inhibitors
    Sean Ekins, Gianpaolo Bravi, Shelly Binkley, Jennifer S. Gillespie, Barbara J. Ring, James H. Wikel and Steven A Wrighton
    Drug Metabolism and Disposition August 2000, 28 (8) 994-1002;
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    Size Limits of Thiocarbamides Accepted as Substrates by Human Flavin-Containing Monooxygenase 1
    Young Mi Kim and Daniel M. Ziegler
    Drug Metabolism and Disposition August 2000, 28 (8) 1003-1006;

Erratum

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    Drug Metabolism and Disposition August 2000, 28 (8) 1007;
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Drug Metabolism and Disposition: 28 (8)
Drug Metabolism and Disposition
Vol. 28, Issue 8
1 Aug 2000
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  • Short Communications
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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