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Drug Metabolism & Disposition

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Table of Contents

September 01, 2000; Volume 28,Issue 9

Short Communications

  • You have access
    Synthesis and Identification of the Quaternary Ammonium-Linked Glucuronide of 1-Phenylimidazole in Human Liver Microsomes and Investigation of the Human UDP-Glucuronosyltransferases Involved
    Sarvesh C. Vashishtha, Edward M. Hawes, Gordon McKay and Denis J. McCann
    Drug Metabolism and Disposition September 2000, 28 (9) 1009-1013;
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    Oxidation of the Novel Oxazolidinone Antibiotic Linezolid in Human Liver Microsomes
    Michael A. Wynalda, Michael J. Hauer and Larry C. Wienkers
    Drug Metabolism and Disposition September 2000, 28 (9) 1014-1017;

Articles

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    Early Events in the Induction of Rat Hepatic UDP-Glucuronosyltransferases, Glutathione S-Transferase, and Microsomal Epoxide Hydrolase by 1,7-Phenanthroline: Comparison with Oltipraz, tert-Butyl-4-hydroxyanisole, andtert-Butylhydroquinone
    John G. Lamb and Michael R. Franklin
    Drug Metabolism and Disposition September 2000, 28 (9) 1018-1023;
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    O-Methylation of Tea Polyphenols Catalyzed by Human Placental Cytosolic Catechol-O-Methyltransferase
    Bao Ting Zhu, Ushma K. Patel, May Xiaoxin Cai and Allan H. Conney
    Drug Metabolism and Disposition September 2000, 28 (9) 1024-1030;
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    An In Vitro Model for Predicting In Vivo Inhibition of Cytochrome P450 3A4 by Metabolic Intermediate Complex Formation
    Bradley S. Mayhew, David R. Jones and Stephen D. Hall
    Drug Metabolism and Disposition September 2000, 28 (9) 1031-1037;
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    Effect of Aging on Tryptophan Hydroxylase in Rat Brain: Implications on Serotonin Level
    Azher M. Hussain and Ashim K. Mitra
    Drug Metabolism and Disposition September 2000, 28 (9) 1038-1042;
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    Cytochrome P450 3A4-Mediated Interaction of Diclofenac and Quinidine
    Jason S. Ngui, Wei Tang, Ralph A. Stearns, Magang Shou, Randall R. Miller, Yong Zhang, Jiunn H. Lin and Thomas A. Baillie
    Drug Metabolism and Disposition September 2000, 28 (9) 1043-1050;
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    Catalysis of the 4-Hydroxylation of Retinoic Acids by Cyp3a7 in Human Fetal Hepatic Tissues
    Hao Chen, Alan G. Fantel and Mont R. Juchau
    Drug Metabolism and Disposition September 2000, 28 (9) 1051-1057;
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    The Disposition of Saquinavir in Normal and P-glycoprotein Deficient Mice, Rats, and in Cultured Cells
    Carla B. Washington, Hugh R. Wiltshire, Martha Man, Tina Moy, Steve R. Harris, Eric Worth, Paul Weigl, Zhenmin Liang, David Hall, Lorraine Marriott and Terrence F. Blaschke
    Drug Metabolism and Disposition September 2000, 28 (9) 1058-1062;
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    A Simple Colorimetric Assay for Phenotyping the Major Human Thermostable Phenol Sulfotransferase (SULT1A1) Using Platelet Cytosols
    Lynn T. Frame, Shogo Ozawa, Susan A. Nowell, Hsien-Chang Chou, Robert R. DeLongchamp, Daniel R. Doerge, Nicholas P. Lang and Fred F. Kadlubar
    Drug Metabolism and Disposition September 2000, 28 (9) 1063-1068;
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    Metabolism of Ezlopitant, a Nonpeptidic Substance P Receptor Antagonist, in Liver Microsomes: Enzyme Kinetics, Cytochrome P450 Isoform Identity, and In Vitro-In Vivo Correlation
    R. Scott Obach
    Drug Metabolism and Disposition September 2000, 28 (9) 1069-1076;
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    Induction of UDP-Glucuronosyltransferase UGT1A1 by the Flavonoid Chrysin in the Human Hepatoma Cell Line Hep G2
    Thomas Walle, Yoko Otake, Alema Galijatovic, Joseph K. Ritter and U. Kristina Walle
    Drug Metabolism and Disposition September 2000, 28 (9) 1077-1082;
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    Isoform Specificity of N-Deacetyl Ketoconazole by Human and Rabbit Flavin-Containing Monooxygenases
    Rosita J. Rodriguez and Cristobal L. Miranda
    Drug Metabolism and Disposition September 2000, 28 (9) 1083-1086;
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      Comparison of Drug Disposition between Wild-Type and Novel Tissue-Type Plasminogen Activator Pamiteplase in Rats
    Keishi Oikawa, Takashi Watanabe and Saburou Higuchi
    Drug Metabolism and Disposition September 2000, 28 (9) 1087-1093;
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    The 1′-Hydroxylation of rac-Bufuralol by Rat Brain Microsomes
    Tanya Coleman, Ellen F. Spellman, Amin Rostami-Hodjegan, Martin S. Lennard and Geoffrey T. Tucker
    Drug Metabolism and Disposition September 2000, 28 (9) 1094-1099;
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    Increased Post-Thaw Viability and Phase I and II Biotransformation Activity in Cryopreserved Rat Liver Slices after Improvement of a Fast-Freezing Method
    I. A. M. de Graaf, D. van der Voort, J. H. F. G. Brits and H. J. Koster
    Drug Metabolism and Disposition September 2000, 28 (9) 1100-1106;
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    Immunoquantitation of FMO1 in Human Liver, Kidney, and Intestine
    Catherine K. Yeung, Dieter H. Lang, Kenneth E. Thummel and Allan E. Rettie
    Drug Metabolism and Disposition September 2000, 28 (9) 1107-1111;
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    Role of Reactive Oxygen Intermediates in the Decrease of Hepatic Cytochrome P450 Activity by Serum of Humans and Rabbits with an Acute Inflammatory Reaction
    Ayman O. S. El-Kadi, Anne-Marie Bleau, Isabelle Dumont, Hélène Maurice and Patrick du Souich
    Drug Metabolism and Disposition September 2000, 28 (9) 1112-1120;
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    CYP3A4 Is Mainly Responsibile for the Metabolism of a New Vinca Alkaloid, Vinorelbine, in Human Liver Microsomes
    Jiro Kajita, Takashi Kuwabara, Hiroyuki Kobayashi and Satoshi Kobayashi
    Drug Metabolism and Disposition September 2000, 28 (9) 1121-1127;
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    Stereoselective Metabolism of Cibenzoline, an Antiarrhythmic Drug, by Human and Rat Liver Microsomes: Possible Involvement of CYP2D and CYP3A
    Toshiro Niwa, Toshifumi Shiraga, Yasuyuki Mitani, Masato Terakawa, Yoji Tokuma and Akira Kagayama
    Drug Metabolism and Disposition September 2000, 28 (9) 1128-1134;

Accelerated Communication

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    Electrophysiological Analysis of the Substrate Selectivity of a Sodium-Coupled Nucleoside Transporter (rCNT1) Expressed inXenopus laevis Oocytes
    Mark J. Dresser, Karin M. Gerstin, Andrew T. Gray, Donald D. F. Loo and Kathleen M. Giacomini
    Drug Metabolism and Disposition September 2000, 28 (9) 1135-1140;
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In this issue

Drug Metabolism and Disposition: 28 (9)
Drug Metabolism and Disposition
Vol. 28, Issue 9
1 Sep 2000
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  • Short Communications
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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