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Drug Metabolism & Disposition

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Table of Contents

October 01, 2001; Volume 29,Issue 10

Short Communication

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    β-Oxidation of Simvastatin in Mouse Liver Preparations
    Thomayant Prueksaritanont, Bennett Ma, Xiaojun Fang, Raju Subramanian, Jian Yu and Jiunn H. Lin
    Drug Metabolism and Disposition October 2001, 29 (10) 1251-1255;

Articles

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    Efflux of Glutathione Conjugate of Monochlorobimane from Striatal and Cortical Neurons
    Heleen H. DeCory, Kristen M. Piech-Dumas, Shey-Shing Sheu, Howard J. Federoff and M. W. Anders
    Drug Metabolism and Disposition October 2001, 29 (10) 1256-1262;
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    Different Enantioselective 9-Hydroxylation of Risperidone by the Two Human CYP2D6 and CYP3A4 Enzymes
    Norio Yasui-Furukori, Mats Hidestrand, Edoardo Spina, Gabriella Facciolá, Maria Gabriella Scordo and Gunnel Tybring
    Drug Metabolism and Disposition October 2001, 29 (10) 1263-1268;
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    In Vitro Metabolism of Tegaserod in Human Liver and Intestine: Assessment of Drug Interactions
    Alison E. M. Vickers, Markus Zollinger, Robert Dannecker, Ronald Tynes, Francis Heitz and Volker Fischer
    Drug Metabolism and Disposition October 2001, 29 (10) 1269-1276;
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    P-Glycoprotein-Mediated In Vitro Biliary Excretion in Sandwich-Cultured Rat Hepatocytes
    Pieter P. Annaert, Ryan Z. Turncliff, Catherine L. Booth, Dhiren R. Thakker and Kim L. R. Brouwer
    Drug Metabolism and Disposition October 2001, 29 (10) 1277-1283;
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    Effects of CYP3A4 Inhibition by Diltiazem on Pharmacokinetics and Dynamics of Diazepam in Relation to CYP2C19 Genotype Status
    Kazuhiro Kosuge, Yang Jun, Hiroshi Watanabe, Masahiko Kimura, Masahiko Nishimoto, Takashi Ishizaki and Kyoichi Ohashi
    Drug Metabolism and Disposition October 2001, 29 (10) 1284-1289;
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    Quaternary Ammonium-Linked Glucuronidation of 1-Substituted Imidazoles: Studies of Human UDP-Glucuronosyltransferases Involved and Substrate Specificities
    Sarvesh C. Vashishtha, Edward M. Hawes, Gordon McKay and Denis J. McCann
    Drug Metabolism and Disposition October 2001, 29 (10) 1290-1295;
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    Formation of Unusual Glutamate Conjugates of 1-[3-(Aminomethyl)phenyl]-N-[3-fluoro-2′-(methylsulfonyl)-[1,1′-biphenyl]- 4-yl]-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC 423) and Its Analogs: The Role of γ-Glutamyltranspeptidase in the Biotransformation of Benzylamines
    Abdul Mutlib, John Shockcor, Shiang-Yuan Chen, Robert Espina, Jianrong Lin, Nilsa Graciani, Shimoga Prakash and Liang-Shang Gan
    Drug Metabolism and Disposition October 2001, 29 (10) 1296-1306;
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    Mechanism of Intestinal Absorption and Renal Reabsorption of an Orally Active Ace Inhibitor: Uptake and Transport of Fosinopril in Cell Cultures
    Cathaleen Shu, Hong Shen, Ulrich Hopfer and David E. Smith
    Drug Metabolism and Disposition October 2001, 29 (10) 1307-1315;
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    Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans
    Yoichi Naritomi, Shigeyuki Terashita, Sumihisa Kimura, Akira Suzuki, Akira Kagayama and Yuichi Sugiyama
    Drug Metabolism and Disposition October 2001, 29 (10) 1316-1324;
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    Calcium Channel Modulators of the Dihydropyridine Family Are Human Pregnane X Receptor Activators and Inducers of CYP3A, CYP2B, and CYP2C in Human Hepatocytes
    Lionel Drocourt, Jean-Marc Pascussi, Eric Assenat, Jean-Michel Fabre, Patrick Maurel and Marie-José Vilarem
    Drug Metabolism and Disposition October 2001, 29 (10) 1325-1331;
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    Influence of Microsomal Concentration on Apparent Intrinsic Clearance: Implications for Scaling in Vitro Data
    J. Cory Kalvass, David A. Tess, Craig Giragossian, Michael C. Linhares and Tristan S. Maurer
    Drug Metabolism and Disposition October 2001, 29 (10) 1332-1336;
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    Tissue Slices Revisited: Evaluation and Development of a Short-Term Incubation for Integrated Drug Metabolism
    Sanjeev Thohan, MaryLynn C. Zurich, Ho Chung, Myron Weiner, Andrew S. Kane and Gerald M. Rosen
    Drug Metabolism and Disposition October 2001, 29 (10) 1337-1342;
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    Tertiary N-Glucuronides of Clozapine and Its Metabolite Desmethylclozapine in Patient Urine
    Ursula Breyer-Pfaff and Helmut Wachsmuth
    Drug Metabolism and Disposition October 2001, 29 (10) 1343-1348;
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    Xenobiotic-Metabolizing Enzyme Activities in Primary Cultures of Rat Type II Pneumocytes and Alveolar Macrophages
    Svetlana Dimova, Peter H. M. Hoet and Benoit Nemery
    Drug Metabolism and Disposition October 2001, 29 (10) 1349-1354;

Accelerated Communication

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    Thalidomide Is Distributed into Human Semen after Oral Dosing
    Steve K. Teo, Jill L. Harden, Alison B. Burke, Faruq H. Noormohamed, Mike Youle, Margaret A. Johnson, Barry S. Peters, David I. Stirling and Steve D. Thomas
    Drug Metabolism and Disposition October 2001, 29 (10) 1355-1357;
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In this issue

Drug Metabolism and Disposition: 29 (10)
Drug Metabolism and Disposition
Vol. 29, Issue 10
1 Oct 2001
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  • Short Communication
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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