Different Enantioselective 9-Hydroxylation of Risperidone by the Two Human CYP2D6 and CYP3A4 Enzymes

Gunnel Tybring Ph.D., Karolinska Institutet, Department of Medical Laboratory Science & Technology, Division of Clinical Pharmacology, Huddinge University Hospital, SE-141 86 Stockholm, Sweden. E-mail:gunnel.tybring{at}labtek.ki.se

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	Abstract	Full	Pdf
Sep 2001	31	50	60
Oct 2001	29	38	39
Nov 2001	15	29	19
Dec 2001	4	16	13
Jan 2002	1	19	16
Feb 2002	1	11	9
Mar 2002	2	31	21
Apr 2002	2	15	7
May 2002	3	20	9
Jun 2002	2	5	9
Jul 2002	3	22	5
Aug 2002	0	10	3
Sep 2002	1	11	17
Oct 2002	3	16	19
Nov 2002	1	21	20
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Feb 2003	0	9	18
Mar 2003	2	6	14
Apr 2003	2	7	11
May 2003	1	8	10
Jun 2003	0	7	11
Jul 2003	6	23	19
Aug 2003	9	26	10
Sep 2003	5	12	9
Oct 2003	10	40	18
Nov 2003	4	21	14
Dec 2003	10	28	18
Jan 2004	13	30	18
Feb 2004	10	24	11
Mar 2004	11	29	15
Apr 2004	9	41	18
May 2004	8	21	14
Jun 2004	22	31	14
Jul 2004	15	22	7
Aug 2004	9	20	13
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Oct 2004	10	39	19
Nov 2004	10	38	10
Dec 2004	7	37	8
Jan 2005	18	41	18
Feb 2005	9	32	10
Mar 2005	11	49	10
Apr 2005	1	25	11
May 2005	6	33	20
Jun 2005	4	22	16
Jul 2005	10	23	12
Aug 2005	3	25	19
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Oct 2005	2	31	15
Nov 2005	4	36	11
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Feb 2006	10	32	18
Mar 2006	8	39	15
Apr 2006	1	21	11
May 2006	2	20	14
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Jul 2006	6	18	13
Aug 2006	3	18	9
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Oct 2006	4	19	18
Nov 2006	9	19	12
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Apr 2007	3	25	24
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Aug 2007	7	26	10
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Oct 2007	15	40	26
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Apr 2008	8	15	16
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Jun 2008	4	13	10
Jul 2008	9	18	13
Aug 2008	7	11	6
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Apr 2009	7	11	8
May 2009	5	20	17
Jun 2009	7	18	14
Jul 2009	6	14	13
Aug 2009	5	26	10
Sep 2009	6	7	5
Oct 2009	24	13	11
Nov 2009	18	14	2
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Jan 2010	29	16	10
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Mar 2010	15	17	14
Apr 2010	12	11	7
May 2010	22	14	10
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Jul 2010	21	17	11
Aug 2010	15	14	10
Sep 2010	7	56	13
Oct 2010	11	28	14
Nov 2010	6	124	9
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Jan 2011	10	23	6
Feb 2011	5	26	8
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Jun 2011	16	9	5
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Oct 2011	35	44	23
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Aug 2012	14	21	6
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Oct 2012	21	26	15
Nov 2012	19	15	11
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Jan 2013	33	21	9
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Apr 2013	25	29	47
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Jun 2013	4	11	10
Jul 2013	9	12	10
Aug 2013	6	10	4
Sep 2013	7	15	14
Oct 2013	7	8	5
Nov 2013	6	8	9
Dec 2013	17	9	12
Jan 2014	14	8	10
Feb 2014	1	9	6
Mar 2014	13	9	9
Apr 2014	4	8	8
May 2014	14	8	5
Jun 2014	6	13	7
Jul 2014	3	21	7
Aug 2014	4	16	6
Sep 2014	4	26	15
Oct 2014	14	17	9
Nov 2014	7	13	7
Dec 2014	6	8	7
Jan 2015	9	11	7
Feb 2015	6	10	4
Mar 2015	18	38	26
Apr 2015	8	19	7
May 2015	5	14	13
Jun 2015	3	16	7
Jul 2015	7	10	13
Aug 2015	9	4	13
Sep 2015	8	13	15
Oct 2015	9	8	11
Nov 2015	6	4	8
Dec 2015	10	6	6
Jan 2016	12	9	10
Feb 2016	6	15	11
Mar 2016	11	8	17
Apr 2016	7	7	13
May 2016	7	13	16
Jun 2016	9	5	12
Jul 2016	5	6	8
Aug 2016	6	1	2
Sep 2016	4	5	8
Oct 2016	8	9	13
Nov 2016	3	9	11
Dec 2016	2	9	4
Jan 2017	2	14	8
Feb 2017	3	10	4
Mar 2017	5	10	6
Apr 2017	4	8	4
May 2017	5	12	11
Jun 2017	2	7	8
Jul 2017	2	10	8
Aug 2017	1	16	5
Sep 2017	1	16	11
Oct 2017	1	16	13
Nov 2017	3	21	6
Dec 2017	2	20	8
Jan 2018	1	18	1
Feb 2018	8	11	8
Mar 2018	1	19	4
Apr 2018	1	22	10
May 2018	2	19	14
Jun 2018	0	20	12
Jul 2018	3	9	6
Aug 2018	1	11	7
Sep 2018	3	11	3
Oct 2018	2	11	5
Nov 2018	5	13	4
Dec 2018	41	8	3
Jan 2019	17	2	2
Feb 2019	16	1	1
Mar 2019	12	4	0
Apr 2019	31	8	9
May 2019	18	3	3
Jun 2019	6	2	0
Jul 2019	14	8	6
Aug 2019	10	1	1
Sep 2019	11	0	0
Oct 2019	10	2	2
Nov 2019	17	1	1
Dec 2019	24	5	1
Jan 2020	18	2	1
Feb 2020	20	2	5
Mar 2020	140	9	6
Apr 2020	24	5	7
May 2020	15	1	0
Jun 2020	8	3	5
Jul 2020	8	1	1
Aug 2020	15	1	13
Sep 2020	18	3	2
Oct 2020	16	1	1
Nov 2020	22	1	0
Dec 2020	31	2	1
Jan 2021	37	5	0
Feb 2021	14	5	0
Mar 2021	10	2	1
Apr 2021	11	4	1
May 2021	21	6	2
Jun 2021	22	3	1
Jul 2021	7	1	0
Aug 2021	35	7	1
Sep 2021	4	7	0
Oct 2021	27	2	0
Nov 2021	25	6	1