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Research ArticleArticle

Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans

Yoichi Naritomi, Shigeyuki Terashita, Sumihisa Kimura, Akira Suzuki, Akira Kagayama and Yuichi Sugiyama
Drug Metabolism and Disposition October 2001, 29 (10) 1316-1324;

Article Information

vol. 29 no. 10 1316-1324
PubMed 
11560875
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 20, 2001
  • Accepted July 3, 2001
  • Published online October 1, 2001.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoichi Naritomi1,
  2. Shigeyuki Terashita1,
  3. Sumihisa Kimura1,
  4. Akira Suzuki1,
  5. Akira Kagayama1 and
  6. Yuichi Sugiyama2
  1. 1Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Kashima, Yodogawa-ku, Osaka, Japan (Y.N., S.T., S.K., A.S., A.K.); and 2Graduate School of Pharmaceutical Sciences, the University of Tokyo, Hongo, Bunkyou-ku, Tokyo, Japan (Y.S.)
  1. Yoichi Naritomi, Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Kashima, Yodogawa-ku, Osaka 532-8514, Japan. E-mail: yoichi_naritomi{at}po.fujisawa.co.jp
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Research ArticleArticle

Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans

Yoichi Naritomi, Shigeyuki Terashita, Sumihisa Kimura, Akira Suzuki, Akira Kagayama and Yuichi Sugiyama
Drug Metabolism and Disposition October 1, 2001, 29 (10) 1316-1324;
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