Prediction of Human Hepatic Clearance from in Vivo Animal Experiments and in Vitro Metabolic Studies with Liver Microsomes from Animals and Humans

Yoichi Naritomi, Biopharmaceutical and Pharmacokinetic Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Kashima, Yodogawa-ku, Osaka 532-8514, Japan. E-mail: yoichi_naritomi{at}po.fujisawa.co.jp

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	Abstract	Full	Pdf
Sep 2001	106	91	279
Oct 2001	54	112	245
Nov 2001	20	64	108
Dec 2001	18	68	77
Jan 2002	17	50	62
Feb 2002	13	72	76
Mar 2002	8	34	38
Apr 2002	6	33	47
May 2002	13	40	25
Jun 2002	9	29	39
Jul 2002	4	39	41
Aug 2002	5	40	28
Sep 2002	23	35	57
Oct 2002	7	40	65
Nov 2002	6	33	63
Dec 2002	3	30	60
Jan 2003	1	35	60
Feb 2003	1	58	60
Mar 2003	4	24	51
Apr 2003	6	28	66
May 2003	3	35	45
Jun 2003	1	34	43
Jul 2003	8	43	69
Aug 2003	7	28	35
Sep 2003	11	32	44
Oct 2003	14	50	65
Nov 2003	10	42	43
Dec 2003	8	37	29
Jan 2004	20	53	62
Feb 2004	11	30	45
Mar 2004	15	67	93
Apr 2004	11	56	55
May 2004	12	54	63
Jun 2004	21	58	56
Jul 2004	14	65	59
Aug 2004	25	54	47
Sep 2004	23	83	72
Oct 2004	18	65	57
Nov 2004	23	82	61
Dec 2004	12	61	63
Jan 2005	30	81	47
Feb 2005	26	87	75
Mar 2005	37	68	67
Apr 2005	19	61	73
May 2005	21	48	62
Jun 2005	43	65	61
Jul 2005	19	74	59
Aug 2005	18	52	57
Sep 2005	13	56	38
Oct 2005	20	61	46
Nov 2005	19	66	72
Dec 2005	28	69	67
Jan 2006	15	68	37
Feb 2006	14	97	70
Mar 2006	17	92	60
Apr 2006	14	62	56
May 2006	31	55	50
Jun 2006	25	66	55
Jul 2006	17	33	46
Aug 2006	16	38	38
Sep 2006	31	42	53
Oct 2006	26	59	42
Nov 2006	16	37	41
Dec 2006	16	30	26
Jan 2007	21	48	40
Feb 2007	32	48	46
Mar 2007	18	56	58
Apr 2007	17	42	62
May 2007	13	50	69
Jun 2007	21	44	55
Jul 2007	25	48	54
Aug 2007	32	43	50
Sep 2007	25	41	54
Oct 2007	39	51	59
Nov 2007	20	51	47
Dec 2007	13	21	26
Jan 2008	13	46	48
Feb 2008	21	47	49
Mar 2008	15	33	39
Apr 2008	19	45	50
May 2008	19	40	51
Jun 2008	14	40	53
Jul 2008	24	40	57
Aug 2008	36	27	65
Sep 2008	41	39	50
Oct 2008	28	43	47
Nov 2008	21	28	45
Dec 2008	18	17	36
Jan 2009	21	32	62
Feb 2009	21	25	44
Mar 2009	20	41	58
Apr 2009	25	38	38
May 2009	17	28	39
Jun 2009	20	30	32
Jul 2009	15	17	34
Aug 2009	30	38	51
Sep 2009	16	40	39
Oct 2009	33	45	58
Nov 2009	37	37	56
Dec 2009	35	20	55
Jan 2010	65	36	53
Feb 2010	43	30	53
Mar 2010	83	29	51
Apr 2010	52	35	41
May 2010	52	45	38
Jun 2010	54	45	53
Jul 2010	56	21	44
Aug 2010	51	33	43
Sep 2010	43	26	33
Oct 2010	51	41	29
Nov 2010	39	65	45
Dec 2010	37	32	34
Jan 2011	46	31	37
Feb 2011	56	33	26
Mar 2011	34	33	52
Apr 2011	26	18	35
May 2011	39	40	62
Jun 2011	33	27	47
Jul 2011	39	46	58
Aug 2011	51	23	54
Sep 2011	50	54	41
Oct 2011	44	29	41
Nov 2011	39	38	52
Dec 2011	26	26	50
Jan 2012	42	44	82
Feb 2012	35	42	79
Mar 2012	50	43	102
Apr 2012	55	64	83
May 2012	36	52	113
Jun 2012	41	32	95
Jul 2012	57	36	129
Aug 2012	39	27	101
Sep 2012	56	29	151
Oct 2012	60	64	175
Nov 2012	41	41	126
Dec 2012	48	41	118
Jan 2013	41	53	158
Feb 2013	51	39	142
Mar 2013	40	22	136
Apr 2013	59	30	93
May 2013	75	33	79
Jun 2013	34	35	74
Jul 2013	39	32	66
Aug 2013	32	12	56
Sep 2013	28	34	56
Oct 2013	47	29	61
Nov 2013	23	36	49
Dec 2013	17	38	55
Jan 2014	46	25	54
Feb 2014	31	27	55
Mar 2014	48	33	53
Apr 2014	32	36	62
May 2014	31	24	49
Jun 2014	30	65	116
Jul 2014	89	32	112
Aug 2014	35	35	110
Sep 2014	53	32	133
Oct 2014	32	29	43
Nov 2014	50	53	107
Dec 2014	29	26	81
Jan 2015	29	31	86
Feb 2015	27	26	74
Mar 2015	31	30	86
Apr 2015	31	30	70
May 2015	46	20	75
Jun 2015	32	38	91
Jul 2015	58	31	92
Aug 2015	29	37	73
Sep 2015	16	31	84
Oct 2015	28	16	74
Nov 2015	48	28	104
Dec 2015	25	15	66
Jan 2016	27	24	92
Feb 2016	28	29	93
Mar 2016	41	42	147
Apr 2016	46	31	96
May 2016	26	19	82
Jun 2016	25	36	117
Jul 2016	24	24	89
Aug 2016	28	41	82
Sep 2016	17	25	61
Oct 2016	19	30	35
Nov 2016	18	64	54
Dec 2016	19	56	42
Jan 2017	17	31	28
Feb 2017	15	35	41
Mar 2017	17	69	54
Apr 2017	19	37	47
May 2017	22	43	85
Jun 2017	18	48	54
Jul 2017	28	39	53
Aug 2017	13	49	38
Sep 2017	16	53	38
Oct 2017	23	57	33
Nov 2017	17	57	43
Dec 2017	23	40	37
Jan 2018	28	41	56
Feb 2018	19	43	63
Mar 2018	24	66	59
Apr 2018	30	70	96
May 2018	12	58	92
Jun 2018	13	59	55
Jul 2018	3	32	75
Aug 2018	10	35	54
Sep 2018	18	24	55
Oct 2018	14	32	45
Nov 2018	21	98	68
Dec 2018	114	28	29
Jan 2019	103	10	10
Feb 2019	98	16	5
Mar 2019	91	27	15
Apr 2019	53	11	8
May 2019	43	11	11
Jun 2019	49	9	10
Jul 2019	37	9	11
Aug 2019	45	16	12
Sep 2019	66	17	12
Oct 2019	78	17	18
Nov 2019	61	14	7
Dec 2019	44	17	7
Jan 2020	76	24	15
Feb 2020	81	17	13
Mar 2020	92	28	17
Apr 2020	120	9	6
May 2020	45	11	9
Jun 2020	116	11	16
Jul 2020	77	9	11
Aug 2020	61	15	19
Sep 2020	97	22	19
Oct 2020	90	15	6
Nov 2020	142	7	7
Dec 2020	98	12	6
Jan 2021	170	66	14
Feb 2021	93	47	16
Mar 2021	205	22	16
Apr 2021	58	5	6