Influence of Microsomal Concentration on Apparent Intrinsic Clearance: Implications for Scaling in Vitro Data

J. Cory Kalvass; David A. Tess; Craig Giragossian; Michael C. Linhares; Tristan S. Maurer

Article Information

vol. 29 no. 10 1332-1336

PubMed

11560877

Published By

American Society for Pharmacology and Experimental Therapeutics

Print ISSN

0090-9556

Online ISSN

1521-009X

History

Received April 4, 2001
Accepted July 19, 2001
Published online October 1, 2001.

The American Society for Pharmacology and Experimental Therapeutics

Author Information

J. Cory Kalvass,
David A. Tess,
Craig Giragossian,
Michael C. Linhares and
Tristan S. Maurer

Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development Groton, Connecticut

Tristan S. Maurer, Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research, Inc., Eastern Point Road, Groton, CT 06340. E-mail:tristan_s_maurer{at}groton.pfizer.com

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