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Research ArticleArticle

Bioactivation of Diclofenac via Benzoquinone Imine Intermediates—Identification of Urinary Mercapturic Acid Derivatives in Rats and Humans

Grace K. Poon, Qing Chen, Yohannes Teffera, Jason S. Ngui, Patrick R. Griffin, Mathew P. Braun, George A. Doss, Christopher Freeden, Ralph A. Stearns, David C. Evans, Thomas A. Baillie and Wei Tang
Drug Metabolism and Disposition December 2001, 29 (12) 1608-1613;

Article Information

vol. 29 no. 12 1608-1613
PubMed 
11717180
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 9, 2001
  • Accepted September 14, 2001
  • Published online December 1, 2001.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Grace K. Poon1,
  2. Qing Chen1,
  3. Yohannes Teffera1,
  4. Jason S. Ngui1,
  5. Patrick R. Griffin2,
  6. Mathew P. Braun1,
  7. George A. Doss1,
  8. Christopher Freeden1,
  9. Ralph A. Stearns1,
  10. David C. Evans1,
  11. Thomas A. Baillie1 and
  12. Wei Tang1
  1. Departments of 1Drug Metabolism (G.K.P., Q.C., Y.T., J.S.N., M.P.B., G.A.D., C.F., R.A.S., D.C.E., T.A.B., W.T.), and 2Chemistry (P.R.G.), Merck Research Laboratories, Rahway, New Jersey
  1. Dr. Wei Tang, Department of Drug Metabolism, Merck & Co., P.O. Box 2000, RY800-B211, Rahway, NJ 07065. E-mail: wei_tang{at}merck.com
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Research ArticleArticle

Bioactivation of Diclofenac via Benzoquinone Imine Intermediates—Identification of Urinary Mercapturic Acid Derivatives in Rats and Humans

Grace K. Poon, Qing Chen, Yohannes Teffera, Jason S. Ngui, Patrick R. Griffin, Mathew P. Braun, George A. Doss, Christopher Freeden, Ralph A. Stearns, David C. Evans, Thomas A. Baillie and Wei Tang
Drug Metabolism and Disposition December 1, 2001, 29 (12) 1608-1613;
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