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Drug Metabolism & Disposition

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Table of Contents

March 01, 2001; Volume 29,Issue 3

MINIREVIEW

  • You have access
    Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How?
    Edward T. Morgan
    Drug Metabolism and Disposition March 2001, 29 (3) 207-212;

Short Communication

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    Lack of Cytochrome P450 2E1 (CYP2E1) Induction in the Rat Liver by Starvation without Coprophagy
    Hye Chin Chung, Sang Hyun Sung, Jin Soo Kim, Young Choong Kim and Sang Geon Kim
    Drug Metabolism and Disposition March 2001, 29 (3) 213-216;

Articles

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    In Vitro Inhibition of Cytochrome P450 Enzymes in Human Liver Microsomes by a Potent CYP2A6 inhibitor, trans-2-Phenylcyclopropylamine (Tranylcypromine), and Its Nonamine Analog, Cyclopropylbenzene
    Päivi Taavitsainen, Risto Juvonen and Olavi Pelkonen
    Drug Metabolism and Disposition March 2001, 29 (3) 217-222;
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    In Vitro Biotransformation of Xanthohumol, a Flavonoid from Hops (Humulus lupulus), by Rat Liver Microsomes
    Meltem Yilmazer, Jan F. Stevens, Max L. Deinzer and Donald R. Buhler
    Drug Metabolism and Disposition March 2001, 29 (3) 223-231;
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    Investigation of the in Vitro Metabolism Profile of a Phosphodiesterase-IV Inhibitor, CDP-840: Leading to Structural Optimization
    Chun Li, Nathalie Chauret, Laird A. Trimble, Deborah A. Nicoll-Griffith, Jose M. Silva, Dwight MacDonald, Helene Perrier, James A. Yergey, Ted Parton, Rakki P. Alexander and Graham J. Warrellow
    Drug Metabolism and Disposition March 2001, 29 (3) 232-241;
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    Induction of CYP2C Genes in Human Hepatocytes in Primary Culture
    Sabine Gerbal-Chaloin, Jean-Marc Pascussi, Lydiane Pichard-Garcia, Martine Daujat, Felix Waechter, Jean-Michel Fabre, Nicolas Carrère and Patrick Maurel
    Drug Metabolism and Disposition March 2001, 29 (3) 242-251;
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    Effects of Bacterial Lipopolysaccharide on Phenobarbital-Induced CYP2B Expression in Mice
    Tong Li-Masters and Edward T. Morgan
    Drug Metabolism and Disposition March 2001, 29 (3) 252-257;
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    Involvement of CYP2E1 and Carboxylesterase Enzymes in Vinyl Carbamate Metabolism in Human Lung Microsomes
    Poh-Gek Forkert, Raymond P. Lee and Ken Reid
    Drug Metabolism and Disposition March 2001, 29 (3) 258-263;
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    Glutathione S-Transferase Activity Influences Busulfan Pharmacokinetics in Patients with Beta Thalassemia Major Undergoing Bone Marrow Transplantation
    Balasubramanian Poonkuzhali, Mammen Chandy, Alok Srivastava, David Dennison and Rajagopal Krishnamoorthy
    Drug Metabolism and Disposition March 2001, 29 (3) 264-267;
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    Novel Mutations of CYP3A4 in Chinese
    Kun-Pin Hsieh, Yen-Yu Lin, Ching-Ling Cheng, Ming-Liang Lai, Min-Shung Lin, Jean-Pascal Siest and Jin-Ding Huang
    Drug Metabolism and Disposition March 2001, 29 (3) 268-273;
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    Enzymatic Characterization and Interspecies Difference of Phenol Sulfotransferases, ST1A Forms
    Wataru Honma, Yoshiteru Kamiyama, Kouichi Yoshinari, Hironobu Sasano, Miki Shimada, Kiyoshi Nagata and Yasushi Yamazoe
    Drug Metabolism and Disposition March 2001, 29 (3) 274-281;
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    A Comparison of the Effects of 3-Hydroxy-3-Methylglutaryl-Coenzyme A (HMG-CoA) Reductase Inhibitors on the CYP3A4-Dependent Oxidation of Mexazolam in Vitro
    Michi Ishigami, Tomoyo Honda, Wataru Takasaki, Toshihiko Ikeda, Toru Komai, Kiyomi Ito and Yuichi Sugiyama
    Drug Metabolism and Disposition March 2001, 29 (3) 282-288;
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    Characterization of 2-[[4-[[2-(1H-Tetrazol-5-ylmethyl)phenyl]methoxy]phenoxy]methyl] Quinoline N-Glucuronidation by in Vitro and in Vivo Approaches
    Jeffrey C. Stevens, Jessica L. Fayer and Kenneth C. Cassidy
    Drug Metabolism and Disposition March 2001, 29 (3) 289-295;
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    Tissue-Specific Alterations in the 6-Hydroxylation of Chlorzoxazone Following Traumatic Brain Injury in the Rat
    Samuel M. Poloyac, Alex Perez, Stephen Scheff and Robert A. Blouin
    Drug Metabolism and Disposition March 2001, 29 (3) 296-298;
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    Elevated Alpha-1-Acid Glycoprotein Reduces the Volume of Distribution and Systemic Clearance of Saquinavir
    John W. Holladay, Michael J. Dewey, Bozena B. Michniak, Hugh Wiltshire, Daniel L. Halberg, Paul Weigl, Zhenmin Liang, Kathryn Halifax, W. Edward Lindup and David J. Back
    Drug Metabolism and Disposition March 2001, 29 (3) 299-303;
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    P450 Enzyme Expression Patterns in the NCI Human Tumor Cell Line Panel
    Li J. Yu, Jocelyn Matias, Dominic A. Scudiero, Karen M. Hite, Anne Monks, Edward A. Sausville and David J. Waxman
    Drug Metabolism and Disposition March 2001, 29 (3) 304-312;
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    PSA-Specific and Non-PSA-Specific Conversion of a PSA-Targeted Peptide Conjugate of Doxorubicin to Its Active Metabolites
    Bradley K. Wong, Deborah DeFeo-Jones, Raymond E. Jones, Victor M. Garsky, Dong-Mei Feng, Allen Oliff, Masato Chiba, Joan D. Ellis and Jiunn H. Lin
    Drug Metabolism and Disposition March 2001, 29 (3) 313-318;
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    Variables in Human Liver Microsome Preparation: Impact on the Kinetics of L-α-Acetylmethadol (LAAM)N-Demethylation and DextromethorphanO-Demethylation
    Ann C. Nelson, Wei Huang and David E. Moody
    Drug Metabolism and Disposition March 2001, 29 (3) 319-325;
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    In Vivo Metabolism of 2,6,9-Trisubstituted Purine-Derived Cyclin-Dependent Kinase Inhibitor Bohemine in Mice: Glucosidation as the Principal Metabolic Route
    Zdeněk Chmela, Jaroslav Veselý, Karel Lemr, Miroslav Rypka, Jan Hanuš, Libor Havlı́ček, Vladimı́r Kryštof, Lucie Michnová, Květoslava Fuksová and Jiřı́ Lukeš
    Drug Metabolism and Disposition March 2001, 29 (3) 326-334;
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    Sulfation is Rate Limiting in the Futile Cycling Between Estrone and Estrone Sulfate in Enriched Periportal and Perivenous Rat Hepatocytes
    Eugene Tan and K. Sandy Pang
    Drug Metabolism and Disposition March 2001, 29 (3) 335-346;
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    Metabolic Characterization of the Major Human Small Intestinal Cytochrome P450s
    R. Scott Obach, Qing-Yu Zhang, Deborah Dunbar and Laurence S. Kaminsky
    Drug Metabolism and Disposition March 2001, 29 (3) 347-352;
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    Differential Induction of Rat Hepatic Cytochromes P450 3A1, 3A2, 2B1, 2B2, and 2E1 in Response to Pyridine Treatment
    Hyesook Kim, David A. Putt, Richard C. Zangar, C. Roland Wolf, F. Peter Guengerich, Robert J. Edwards, Paul F. Hollenberg and Raymond F. Novak
    Drug Metabolism and Disposition March 2001, 29 (3) 353-360;
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Drug Metabolism and Disposition: 29 (3)
Drug Metabolism and Disposition
Vol. 29, Issue 3
1 Mar 2001
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  • MINIREVIEW
  • Short Communication
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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