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Review ArticleMINIREVIEW

Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How?

Edward T. Morgan
Drug Metabolism and Disposition March 2001, 29 (3) 207-212;
Edward T. Morgan
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This article has a correction. Please see:

  • Correction to “Minireview: Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How?” - June 01, 2001

Abstract

Expression and activities of cytochrome P450 enzymes are down-regulated in the liver during the host response to inflammation or infection, leading to alterations in drug clearance and toxin activation. This review focuses on recent studies on the mechanisms of this down-regulation, as well as the cytokines and cell types involved. Possible reasons for cytochrome P450 down-regulation are discussed.

Footnotes

  • Send reprint requests to: Edward T. Morgan, Ph.D., Department of Pharmacology, Emory University, 1510 Clifton Rd., Atlanta, GA 30322. E-mail: etmorga{at}bimcore.emory.edu

  • This work was supported by Grants GM46897 and GM53093 from the National Institute of General Medical Sciences.

  • Abbreviations used are::
    P450
    cytochrome P450
    LPS
    bacterial lipopolysaccharide
    NO
    nitric oxide
    NOS2
    inducible NO synthase
    EET
    epoxyeicosatrienoic acid
    TNFα
    tumor necrosis factor-α
    IL
    interleukin
    NF
    nuclear factor
    PPARα
    peroxisome proliferator-activated receptor-α
    • Received October 11, 2000.
    • Accepted December 12, 2000.
  • The American Society for Pharmacology and Experimental Therapeutics
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Drug Metabolism and Disposition: 29 (3)
Drug Metabolism and Disposition
Vol. 29, Issue 3
1 Mar 2001
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Review ArticleMINIREVIEW

Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How?

Edward T. Morgan
Drug Metabolism and Disposition March 1, 2001, 29 (3) 207-212;

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Review ArticleMINIREVIEW

Regulation of Cytochrome P450 by Inflammatory Mediators: Why and How?

Edward T. Morgan
Drug Metabolism and Disposition March 1, 2001, 29 (3) 207-212;
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  • Article
    • Abstract
    • Causes of Interindividual Variation in Drug Metabolism
    • Regulation of P450 by Inflammation and Infection
    • Rodent Models and Human Studies
    • P450 Down-Regulation: A Homeostatic Mechanism or a Pathophysiological Phenomenon?
    • Humoral Factors and Cell Types Involved in P450 Down-Regulation
    • Molecular Mechanisms of Down-Regulation
    • Conclusion
    • Footnotes
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